Abstract: A self-adhesive, biocompatible and hydratable polymeric matrix has the form of a sheet, patch or film. The matrix is suitable for application to moist surfaces both inside and on the external surface of the body. The matrix comprises a naturally occurring or synthetic polymerisable and/or cross-linkable material that supports wound healing, and a synthetic polymer having bioadhesive properties. The bioadhesive properties enable the matrix to adhere to underlying tissue by means of ionic and or hydrogen bonding.