Abstract: A microsampling system includes a housing, a capillary fixed within a sealed internal environment defined by the housing, a robotic translation mechanism configured to support a sample holder and move the sample holder relative to the capillary in a plurality of directions, and a first port for connecting the sealed internal environment to a fluid source. A plurality of second ports may connect the sealed internal environment to a computing device, a voltage source, and/or a mass spectrometer ESI interface. A method of microsampling includes moving a sample holder within a sealed internal environment to operably position a capillary relative to a sample volume, pressurizing the sealed internal environment to inject a sample volume into the capillary, moving the sample holder to operably position the capillary relative to a BGE coupled to a voltage source, and applying electrical energy to separate the first sample volume via capillary electrophoresis.

Abstract: Systems and methods for specialized data acquisition in capillary electrophoresis electrospray ionization mass spectrometry (MS) that includes (a) mass-to-charge (m/z) vs. migration time (MT) correlation, (b) ion mobility (IM) vs. MT correlation, and (c) m/z vs. IM vs. MT correlation to advance molecular analysis via data-dependent, data-independent, and targeted analysis methods executed on mass spectrometers using diverse types of mass analyzers, including but not limited to orbitrap, time-of-flight, and ion mobility time-of-flight mass analyzers. Electrophoresis-correlative (Eco) MS enhances the detection, identification, and quantification of molecules, as is demonstrated here for complex proteome samples.

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI)

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).

Abstract: The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI).