Abstract: Methods and kits for identifying agents that modulate the function of the Methods and kits for identifying agents that modulate the function of the receptor Fzd8 are provided. Accordingly, the present invention makes available methods for identifying agents useful as modulators of Wnt-Fzd8 signalling. Therapeutic uses of the identified agents for treating osteoarthitis are also provided.

Abstract: The invention relates to a novel method of treatment or prophylaxis of osteoarthritis, which comprises administering to a patient in need thereof a therapeutically effective amount of an alpha 7 nicotinic AcetylCholine receptor agonist of Formula (I), or a pharmaceutically acceptable salt thereof:

Abstract: Use of a compound of formula (I): wherein: R1 is phenyl optionally substituted by halogen, cyano, C1-4 alkyl or C1-4 haloalkyl; R2 is hydrogen, C1-6 alkyl or C3-6 cycloalkyl; and R3 is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states).