Abstract: The invention concerns a method and an apparatus for mechanical stimulation in vitro of tissue, wherein tissue patches (1) are retained in a tissue carrier (2), thereby presenting first surfaces (3) to be stimulated in a plane (X) and wherein a roller (4) having a second surface (5) arranged at its periphery is moved parallel to said plane (X), thereby imposing selected forces on said first surfaces (3) by said second surface (5) for stimulating the tissue patches (1). By presenting the surfaces (3) to be stimulated in a common plane (X) and by moving the roller (4) parallel to said common plane (X) of the first surfaces (3), serving several tissue carriers (2) with one roller (4) is made easy, thus integration into an industrial production is made practicable.

Abstract: A device has a source for emitting near infrared radiation into cerebral tissue, a sensor for detecting radiation exiting from the tissue, and an evaluation unit which detects the exiting radiation as an input signal having pulsatile and non-pulsatile components and is programmed to determine the concentration of an injected indicator in the tissue from the non-pulsatile signal component, iteratively determine an inflow function characterizing cerebral blood flow by varying a mean transit time until reaching a stop criterion, determine indicator concentration relative to cerebral blood volume from the inflow function and the pulsatile signal component, calculate cerebral blood volume by dividing indicator concentration in the tissue by indicator concentration relative to cerebral blood volume, calculate cerebral blood flow by dividing the cerebral blood volume by the mean transit time when the stop criterion has been reached, and scale the inflow function using values determined from the pulsatile signal comp

Abstract: A probe and an apparatus for cerebral diagnostics and therapy, in particular for measuring absolute values of regional cerebral flow (CBF) and cerebral oxygenation. The probe is inserted through a burr hole in the skull and comprises illuminating device, light receiving device and a coating encapsulating said illuminating device and said light receiving means. The coating has a longitudinal shape and is adapted to fit through a burr hole in the skull. The coating is further adapted to slide between the skull and the dura, to be inserted into the ventricular system, and/or to be inserted into the cerebral tissue.

Abstract: The invention concerns a method and an apparatus for mechanical stimulation in vitro of tissue, wherein tissue patches (1) are retained in a tissue carrier (2), thereby presenting first surfaces (3) to be stimulated in a plane (X) and wherein a roller (4) having a second surface (5) arranged at its periphery is moved parallel to said plane (X), thereby imposing selected forces on said first surfaces (3) by said second surface (5) for stimulating the tissue patches (1). By presenting the surfaces (3) to be stimulated in a common plane (X) and by moving the roller (4) parallel to said common plane (X) of the first surfaces (3), serving several tissue carriers (2) with one roller (4) is made easy, thus integration into an industrial production is made practicable.

Abstract: A device has a source for emitting near infrared radiation into cerebral tissue, a sensor for detecting radiation exiting from the tissue, and an evaluation unit which detects the exiting radiation as an input signal having pulsatile and non-pulsatile components and is programmed to determine the concentration of an injected indicator in the tissue from the non-pulsatile signal component, iteratively determine an inflow function characterizing cerebral blood flow by varying a mean transit time until reaching a stop criterion, determine indicator concentration relative to cerebral blood volume from the inflow function and the pulsatile signal component, calculate cerebral blood volume by dividing indicator concentration in the tissue by indicator concentration relative to cerebral blood volume, calculate cerebral blood flow by dividing the cerebral blood volume by the mean transit time when the stop criterion has been reached, and scale the inflow function using values determined from the pulsatile signal comp

Abstract: The invention relates to a probe (1) and an apparatus for cerebral diagnostics and therapy, in particular for measuring absolute values of regional cerebral flow (CBF) and cerebral oxygenation. The probe is inserted through a burr hole in the skull and comprises illuminating means, light receiving means and a coating encapsulating said illuminating means and said light receiving means. The coating has a longitudinal shape and is adapted to fit through a burr hole in the skull. Said coating is further adapted to slide between the skull and the dura, to be inserted into the ventricular system, and/or to be inserted into the cerebral tissue.