Abstract: Provided herein are improved delivery systems for oligonucleotides, said delivery system comprising a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide, which targets a BCL2-encoding polynucleotide. Methods of treating patients with said delivery systems are also provided.

Abstract: Systems, methods, and software for developing application usage information are provided herein. An exemplary method includes identifying data sources that relate to application usage activity of one or more users, determining activity signals related to at least data analysis by the one or more users from among the application usage activity, and applying the activity signals to a knowledge graphing service that infers data analysis preferences from among the activity signals. The method also includes providing ones of the data analysis preferences for use by data insight services that establish data insight objects visualizing target datasets based at least on the ones of the data analysis preferences.

Abstract: The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: A method of making a composite compact or briquette may include mixing a first particulate material with at most 15% by weight of a powder coating material to obtain a mixture, and compacting the mixture into a compact. Either the first particulate material, the powder coating material, or both are advantageously waste materials. The first particulate material has a metal content of at least 50% by weight. The compact can be cured at temperatures between 50° C. and 300° C. to obtain the composite briquette. The composite briquette may include a binding phase formed of the cured waste powder coating material, and a dispersed phase formed of the first particulate. The composite briquettes can be used as a secondary ore material.

Abstract: A surgical fastener applier including a housing containing a compartment, an elongated member extending distally from the housing, first and second jaws and a firing mechanism. The firing mechanism is movable between a first position and a second position to effect firing of fasteners into the tissue clamped between the first and second jaws. A power pack is removably loadable into the compartment, the power pack having a motor and an engagement member removably engageable with the firing mechanism within the compartment when the power pack is loaded into the compartment to effect movement of the firing mechanism. An interchangeable battery pack is removably loadable into the power pack for powering the motor. Bearings restrict axial and radial movement of the firing and articulation assembly in the power pack.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: Systems, methods, and software for data visualization frameworks are provided herein. An exemplary method includes identifying a target dataset from which to determine data insights for presentation in an insight interface to the user application. The method includes determining data insight candidates for the target dataset based at least on usage modalities associated with processing one or more past datasets, and establishing content of the data insight candidates according to at least the target dataset and the usage modalities, where the content of each of the data insight candidates includes at least one insight object described by object metadata that indicates at least a processing lineage used to produce the at least one insight object.

Abstract: A composite backer board for wet space construction is disclosed, along with a method of producing the backer board. The board includes a rigid foam core of a suitable thickness for wet space construction. A first fabric layer is fixed to at least one face of the rigid foam core with a polymeric adhesive. A first polymer layer is on the first fabric layer in which the polymer layer is dimensionally stable parallel to the face of the rigid foam core. A second fabric layer is on the first polymer layer opposite the first fabric layer and forms a first face that is amenable to thin set mortar and related compositions in wet space construction.

Abstract: A low dead-volume connector for fluid chromatography, such as liquid chromatography and gas chromatography, has a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.

Abstract: A composite backer board for wet space construction is disclosed, along with a method of producing the backer board. The board includes a rigid foam core of a suitable thickness for wet space construction. A first fabric layer is fixed to at least one face of the rigid foam core with a polymeric adhesive. A first polymer layer is on the first fabric layer in which the polymer layer is dimensionally stable parallel to the face of the rigid foam core. A second fabric layer is on the first polymer layer opposite the first fabric layer and forms a first face that is amenable to thin set mortar and related compositions in wet space construction.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

Abstract: A system (and corresponding methodology) by which a user can interact directly with visual data is provided. The system employs associations and relationships between visual data objects to automatically update objects based upon a change in other objects. The innovation also provides specialized controls (e.g., dashboard tools/controls) that facilitate manipulation of visual data. As there can be numerous manners in which a user can interact with visualization data, the innovation enables a specialized set of controls to be identified and provided to a user thereby reducing overwhelming effects of a large number of controls.

Abstract: The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

Abstract: Provided herein are therapeutic oligonucleotides that comprise at least one p-ethoxy backbone linkage but no more than 80% p-ethoxy backbone linkages. Provided herein are improved delivery systems for therapeutic oligonucleotides comprising a liposome that comprises neutral phospholipids and a p-ethoxy oligonucleotide that is entrapped in the liposome.

Abstract: Systems, methods, and software for data visualization frameworks are provided herein. An exemplary method includes producing a data insight object for a target dataset, the data insight object comprising an object insight portion for presentation to a user and an object metadata portion that indicates at least a processing lineage used to produce the data insight object. The method includes providing the data insight object for presentation by an insight interface to the user application, and responsive to identifying a user action related to at least the target dataset, applying the processing lineage to produce at least one different data insight object for presentation by the insight interface.

Abstract: Systems, methods, and software for data visualization frameworks are provided herein. An exemplary method includes identifying a target dataset from which to determine data insights for presentation in an insight interface to the user application. The method includes determining data insight candidates for the target dataset based at least on usage modalities associated with processing one or more past datasets, and establishing content of the data insight candidates according to at least the target dataset and the usage modalities, where the content of each of the data insight candidates includes at least one insight object described by object metadata that indicates at least a processing lineage used to produce the at least one insight object.

Abstract: Systems, methods, and software for developing application usage information are provided herein. An exemplary method includes identifying data sources that relate to application usage activity of one or more users, determining activity signals related to at least data analysis by the one or more users from among the application usage activity, and applying the activity signals to a knowledge graphing service that infers data analysis preferences from among the activity signals. The method also includes providing ones of the data analysis preferences for use by data insight services that establish data insight objects visualizing target datasets based at least on the ones of the data analysis preferences.

Abstract: The invention generally relates to a low dead-volume connector for fluid chromatography, such as liquid chromatography and gas chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.