Abstract: A mobile telephone terminal provides a user with a selectable option to transfer a telephone call to an instant messaging session and to transfer an instant messaging session to a telephone call. A presence attribute indicator for a first party is displayed, in a mobile telephone application, with an entry associated with the telephone number of the first party. A user, while displaying an entry for a party in a mobile telephone application, has a selectable option for initiating instant messaging with the party. The mobile telephone provides a customised menu of selectable options for initiating communication. The menu is dependent upon received presence attribute information. A calendar application can store the content of an instant messaging dialaogue in an appointment record.

Abstract: A rapid and sensitive detection method capable of reliably distinguishing fragments identical to a defined sequence from fragments containing a single base pair mismatch relative to the defined sequence. The method employs a peptide analog antisense probe, such as a peptide nucleic acid (PNA) probe, which hybridizes with DNA to forms complexes having higher thermal stability, but greater sensitivity to base pair mismatches, than corresponding DNA/DNA complexes. The method may be used in a number of applications, including genetic screening and hybridization sequencing applications.