Abstract: The respiratory medicine delivery system is a handheld breathing device for a user having respiratory problems. The device comprises a hollow tubular manifold. A front tubular section extends from a front opening of the hollow tubular manifold. A mouthpiece extends from a rear opening of the hollow tubular manifold. The front tubular section has an MDI port. A seal cap that can seal off the MDI port is provided. A PEEP valve is mounted in the front tubular section to create a sealed backpressure in the user's airways by creating resistance to exhalation. The hollow tubular manifold has a manifold inlet. A threaded nebulizer port having a recessed one-way valve can be formed at the inlet of the manifold. The nebulizer port is provided for attachment to a nebulizer to facilitate buildup of positive pressure and delivery of medication to a user's lungs. A nebulizer seal cap is also provided.