Abstract: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.

Abstract: A vehicle brake system includes first and second central control units communicating with, respectively, first and second control networks, and a plurality of brake units. Each brake unit includes a brake component, a self-enforcing mechanism associated with and acting upon the brake component, and first and second actuation mechanisms acting upon the self enforcing mechanism, in response to, respectively, first and second actuation control signals, to cause actuation of the brake component. Each brake unit also includes first and second local control units in direct communication with, respectively, the first and second central control units via, respectively, the first and second control networks.

Abstract: A self-supporting suspension device may include vertically oriented columns. The columns may be releasably fastened to one or two feet by being inserted into slots of the respective feet and by surrounding a portion thereof. A stabilisation element may be fastened to two adjacent columns for lateral stability of the suspension device, and a locking beam or the stabilisation element may increase the torsional rigidity of the columns.

Abstract: There is provided compounds of formula (I): wherein Y, ring A, D1, D2, D3, L1, Y1, L2, Y2, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract: A transport unit comprises a load carrier, a load which comprises at least one coil of a web; the web being wound on a reel, a load distributing element, and a tightening strap, the load being carried by said load carrier in such a manner that the reel of said at least one coil is arranged perpendicular to the load carrier, the load having an upper surface facing said load distributing element, the load distributing element being arranged on the upper surface of the load, and the tightening strap enclosing a force-absorbing structure formed of the load carrier, the reel and the load distributing element and adapted to secure the load to the load carrier. The load carrier has a flat load surface, and the web comprises interconnected container blanks, the load having a lower surface which rests on the load surface and comprises an end face of the reel of the at least one coil and a bottom surface formed of a bottom edge of the web of interconnected container blanks.

Abstract: There is provided compounds of formula (I), wherein Rx, Ry, X1, X2, L1, L2, Y1 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

Abstract: The present invention provides a wafer (3) comprising a through-wafer via (7) through the wafer (3) formed by a through-wafer via hole (9) and at least a first conductive coating (25). A substantially vertical sidewall (11) of the through-wafer via hole (9) except for a constriction (23) provides a reliable through-wafer via (7) occupying a small area on the wafer. The wafer (3) is preferably made of a semiconductor material, such as silicon, or a glass ceramic. A method for manufacturing such a wafer (3) is described.

Abstract: An injection syringe comprises a tubular housing, a hollow plunger disposed for reciprocating displacements, partly in the housing, between an advanced and a retracted position, an elongated retraction member arranged for being moved from an advanced to a retracted position in relation to the plunger with at least a part of the retraction member placed inside the plunger, and a spring acting with a spring power between the plunger and the retraction member; a hypodermic needle, displaceable between a first position, wherein it is releasable mounted in the housing and a part of the needle is protruding from the housing, and a second position, wherein the needle is retracted into the housing or the plunger; a releasable retainer arrangement acting between the plunger and the retraction member for retaining the retraction member in its advanced position in relation to the plunger, a releasing mechanism for releasing the retainer when the plunger is in or close to its advanced position, and a coupling for connect

Abstract: A fluid system includes a controllable first pump unit for supplying fluid pressure to at least one implement; a prime mover arranged to supply a driving torque to the first pump The first pump unit is arranged to supply fluid pressure to the implement. The fluid system further includes a controllable second pump unit connected to a fluid accumulator. The prime mover is arranged to supply a driving torque to the second pump unit in order to accumulate fluid pressure in the accumulator during periods of low demand. Fluid pressure from the accumulator is arranged to drive the second pump unit to assist the prime mover during periods of high demand in order to supply an additional driving torque in excess of the available driving torque from the prime mover.

Abstract: A cooling system (100) for an engine (150), comprising at least one coolant pump (120) for pumping a coolant through the engine (150) and a thermostat (140) operable to selectively direct said coolant from said engine (150) via a bypass (115) back to said engine (150) or via a main radiator (110) back to said engine (150) in response to a temperature of said coolant from said engine (150), and an expansion vessel (130) for deaerating said cooling system (100). The system (100) includes a first deaeration conduit (13V) connecting a high point of said engine (150) to said expansion vessel (130), and a second deaeration conduit (138?) connecting a high point of said main radiator (110) to said expansion vessel, and said first and second deaeration conduits (137?, 138?) are provided with at least one heat exchanger (145, 145?) for cooling coolant flowing through said deaeration conduits (137?, 138?).

Abstract: A tool holder is adapted for attachment to a C-shaped suspension bar. In at least one embodiment, the tool holder includes a hook device for suspending an object and a fastening device which enables the hook device to be releasably attached to the suspension bar. The fastening device includes a first and a second portion for retaining engagement with the web of the suspension bar and its respective flanges. The first portion forms the upper portion of the fastening device, when mounted, to which portion the hook device is fixedly attached either directly or indirectly. The second portion of the fastening device is pivotally attached to the first portion via a joint, which, with the tool holder in its mounted state, is oriented parallel with and located between the flanges of the suspension bar.

Abstract: The present invention relates to a method for detecting the presence of a pathogenic prion species in a sample comprising the steps—bringing the sample in contact with at least one conjugated polyelectrolyte (CPE)—irradiating the CPE with electromagnetic radiation—measuring the radiation emitted or absorbed by the CPE at at least one wavelength, and—comparing the measured emitted or absorbed radiation to at least one reference value corresponding to the CPE interacting with a known prion species. Optionally, the emitted or absorbed radiation is measured at least two wavelengths and a ratio is formed of the values of the measured radiation. The method facilitates differentiation between different strains of pathogenic prion species. The invention also relates to devices for performing the method.

Abstract: There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Abstract: An image acquisition device may include a sensing unit to register optical information and convert it into raw image data including intensity information associated with the optical information; and a processing unit to convert the raw image data into digital image information, where the processing unit is configured to identify one or more objects in the converted digital image information and store coordinates associated with the identified one or more objects as metadata.

Abstract: A transport unit comprises a load carrier, a load which comprises at least one coil of a web; the web being wound on a reel, a load distributing element, and a tightening strap, the load being carried by said load carrier in such a manner that the reel of said at least one coil is arranged perpendicular to the load carrier, the load having an upper surface facing said load distributing element, the load distributing element being arranged on the upper surface of the load, and the tightening strap enclosing a force-absorbing structure formed of the load carrier, the reel and the load distributing element and adapted to secure the load to the load carrier. The load carrier has a flat load surface, and the web comprises interconnected container blanks, the load having a lower surface which rests on the load surface and comprises an end face of the reel of the at least one coil and a bottom surface formed of a bottom edge of the web of interconnected container blanks.

Abstract: There is provided compounds of formula I, wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Abstract: There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Abstract: There is provided compounds of formula (I), wherein X1 to X5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Abstract: An electronically controlled braking system includes at least one central control unit, the at least one central control unit operable to assign identifiers during an identifier assignment routine, a first distributed electronic control unit, a second distributed electronic control unit and a control network over which the at least one control unit, the first distributed electronic control unit and the second distributed electronic control unit are communicable. The identifiers include a first identifier and a second identifier, one of which is assigned to the first distributed electronic control unit and the other which is assigned to the second distributed electronic control unit at least in part based upon the timing of identification signals generated by the first distributed electronic control unit and the second distributed electronic control unit reaching the central control unit via the control network.

Abstract: A vehicle brake system includes first and second central control units communicating with, respectively, first and second control networks, and a plurality of brake units. Each brake unit includes a brake component, a self-enforcing mechanism associated with and acting upon the brake component, and first and second actuation mechanisms acting upon the self enforcing mechanism, in response to, respectively, first and second actuation control signals, to cause actuation of the brake component. Each brake unit also includes first and second local control units in direct communication with, respectively, the first and second central control units via, respectively, the first and second control networks.