Patents by Inventor Peter Olafs Olins

Peter Olafs Olins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
    Patent number: 6017523
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain one to three amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (corresponding to residues 119 to 133) have been deleted from the C-terminus, and which also contain one to three amino acid substitutions in the polypeptide.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 25, 2000
    Assignee: G.D. Searle & Co.
    Inventors: S. Christopher Bauer, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, John Patrick McKearn, Peter Olafs Olins
  • Recombinant human interleukin-3 (IL-3) multiple mutation polypeptides
    Patent number: 5817486
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (a.a.119 to 133) have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 6, 1998
    Assignee: G. D. Searle & Co.
    Inventors: S. Christopher Bauer, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, John Patrick McKearn, Peter Olafs Olins