Patents by Inventor Peter Olson

Peter Olson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination Therapies
    Publication number: 20260102401
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a PARP inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 16, 2026
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: JILL HALLIN, PETER OLSON
  • COMPOSITIONS OF ADAGRASIB AND mTOR INHIBITORS AND METHODS OF TREATMENT THEREWITH
    Publication number: 20260097038
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a mTOR inhibitor and a KRas G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: December 2, 2025
    Publication date: April 9, 2026
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: Peter Olson, Ruth Wei Aranda, James Gail Christensen, Lars Daniel Engstrom, Jill Hallin
  • Compositions of adagrasib and mTOR inhibitors and methods of treatment therewith
    Patent number: 12527795
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a mTOR inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: January 20, 2026
    Assignee: Mirati Therapeutics, Inc.
    Inventors: Peter Olson, Ruth Wei Aranda, James Gail Christensen, Lars Daniel Engstrom, Jill Hallin
  • Combination of palbociclib and adagrasib for lung cancer
    Patent number: 12485122
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a CDK 4/6 inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: December 2, 2025
    Assignee: MIRATI THERAPEUTICS, INC.
    Inventors: James Gail Christensen, Ruth Wei Aranda, Lars Daniel Engstrom, Jill Hallin, Peter Olson
  • COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20250312343
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors are methylthioadenosine (MTA)-cooperative PRMT5 inhibitors, particularly in combination with KRASG12D inhibitors.
    Type: Application
    Filed: April 7, 2025
    Publication date: October 9, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: LARS DANIEL ENGSTROM, PETER OLSON, JILL HALLIN
  • COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20250312351
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are methylthioadenosine (MTA)-cooperative PRMT5 inhibitors, particularly in combination with SOS1 checkpoint inhibitors.
    Type: Application
    Filed: April 7, 2025
    Publication date: October 9, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: LARS DANIEL ENGSTROM, PETER OLSON, JILL HALLIN
  • COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20250312344
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are methylthioadenosine (MTA)-cooperative PRMT5 inhibitors, particularly in combination with one or more immuno-oncology checkpoint inhibitors.
    Type: Application
    Filed: April 7, 2025
    Publication date: October 9, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: LARS DANIEL ENGSTROM, PETER OLSON, JILL HALLIN
  • COMBINATION THERAPIES
    Publication number: 20250262213
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a pan ErbB family inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: May 5, 2025
    Publication date: August 21, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: James Gail Christensen, Lars Daniel Engstrom, Ruth Wei Aranda, Jill Hallin, Peter Olson
  • COMBINATIONS OF KRAS G12D INHIBITORS WITH IRINOTECAN AND RELATED METHODS OF TREATMENT
    Publication number: 20250249003
    Abstract: The present invention relates to combination therapies for treating KRas G12D cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of irinotecan (or an analog thereof) and a KRas G12D inhibitor, pharmaceutical compositions comprising a such compositions, kits comprising such compositions and methods of use thereof.
    Type: Application
    Filed: October 4, 2022
    Publication date: August 7, 2025
    Inventors: Jill Hallin, James Gail Christensen, Vickie Bowcut, Peter Olson
  • Combination therapies
    Patent number: 12377101
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a SHP-2 inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 5, 2025
    Assignee: MIRATI THERAPEUTICS, INC.
    Inventors: James Gail Christensen, Lars Daniel Engstrom, Peter Olson, Ruth Wei Aranda
  • COMBINATION THERAPIES
    Publication number: 20250213579
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Src-family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: March 18, 2025
    Publication date: July 3, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: LARS DANIEL ENGSTROM, RUTH WEI ARANDA, PETER OLSON, JAMES GAIL CHRISTENSEN
  • Combination therapies
    Patent number: 12336995
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a pan ErbB family inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: June 24, 2025
    Assignee: MIRATI THERAPEUTICS, INC.
    Inventors: James Gail Christensen, Lars Daniel Engstrom, Ruth Wei Aranda, Jill Hallin, Peter Olson
  • COMBINATION THERAPIES
    Publication number: 20250108055
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: October 3, 2024
    Publication date: April 3, 2025
    Inventors: Ruth Wei Aranda, James Gail Christensen, Lars Daniel Engstrom, Jill Hallin, Peter Olson
  • Combination Therapies Using PRMT5 Inhibitors for the Treatment of Cancer
    Publication number: 20250073241
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with CDK4/6 inhibitors.
    Type: Application
    Filed: November 19, 2024
    Publication date: March 6, 2025
    Applicant: MIRATI THERAPEUTICS, INC.
    Inventors: Lars Daniel Engstrom, Peter Olson, James Gail Christensen
  • Combination therapies
    Patent number: 12208099
    Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: January 28, 2025
    Assignee: Mirati Therapeutics, Inc.
    Inventors: Ruth Wei Aranda, James Gail Christensen, Lars Daniel Engstrom, Jill Hallin, Peter Olson
  • COMBINATION THERAPIES OF KRAS G12D INHIBITORS WITH SOS1 INHIBITORS
    Publication number: 20250000863
    Abstract: The present invention relates to combination therapies for treating KRas G12D cancers, In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a SOS1 inhibitor and a KRAS G12D inhibitor of Formula (I), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use thereof.
    Type: Application
    Filed: October 4, 2022
    Publication date: January 2, 2025
    Inventors: Jill Hallin, James Gail Christensen, Vickie Bowcut, Peter Olson
  • Combination Therapies Using PRMT5 Inhibitors for the Treatment of Cancer
    Publication number: 20240423987
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with KRASG12C inhibitors.
    Type: Application
    Filed: September 5, 2024
    Publication date: December 26, 2024
    Inventors: Lars Daniel Engstrom, Peter Olson, James Gail Christensen
  • COMBINATION THERAPIES OF KRAS G12D INHIBITORS WITH SHP-2 INHIBITORS
    Publication number: 20240423984
    Abstract: The present invention relates to combination therapies for treating KRas G12D cancers, In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a. therapeutically effective amount of a combination of a SHP-2 inhibitor and a KRAS G12D inhibitor of Formula (I), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use thereof.
    Type: Application
    Filed: October 4, 2022
    Publication date: December 26, 2024
    Inventors: Jill Hallin, James Gail Christensen, Vickie Bowcut, Peter Olson
  • Combination therapies using PRMT5 inhibitors for the treatment of cancer
    Patent number: 12171765
    Abstract: This disclosure relates to methods of treating cancer. This disclosure further relates to treating cancer in a subject with compounds that are inhibitors of PRMT5, particularly in combination with CDK4/6 inhibitors.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: December 24, 2024
    Assignee: MIRATI THERAPEUTICS, INC.
    Inventors: Lars Daniel Engstrom, Peter Olson, James Gail Christensen
  • COMBINATION THERAPIES OF KRAS G12D INHIBITORS WITH Pan ErbB FAMILY INHIBITORS
    Publication number: 20240408099
    Abstract: The present invention relates to combination therapies for treating KRas G12D cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a pan ErbB family inhibitor and a KRAS G12D inhibitor of Formula (I), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: October 4, 2022
    Publication date: December 12, 2024
    Inventors: Jill Hallin, James Gail Christensen, Vickie Bowcut, Peter Olson