Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: A roller assembly for use in a conveyor system is disclosed. The roller assembly includes a shaft and a roller rotatably mounted to the shaft. In one embodiment, the roller is made of ultra-high molecular weight plastic. Each roller has first and second ends. The roller assembly further includes a first collar and a second collar mounted on the shaft. The first collar is positioned at the first end of the roller and the second collar is positioned at the second end of the roller. Each collar is selectably affixable to the shaft so as to hold the roller in a fixed position along the length of the shaft.

Abstract: A disinfecting system includes a housing. An ultraviolet light (UV) source is secured to the housing and configured to emit UV light for disinfection of a target. A processor is secured to the housing in communication with the UV light source. The processor is configured to activate the UV light source for a selected amount of time suitable for disinfection of the target.

Abstract: A wireless communication system supports communication between an end node of a vehicle and a correspondent node via a fixed network and wireless modems located with the vehicle. The fixed network comprises a mobility anchor being a common mobility anchor for the wireless modems and performing individual mobility management for each wireless modem, the mobility management for a wireless modem including determining communication paths from the mobility anchor to the wireless modem. A multipath proxy couples a proxy connection for the correspondent node to a plurality of subflows, each subflow being associated with one wireless modem and with the communication path determined by the mobility anchor, at least two of the subflows having communication paths via different wireless modems. The wireless modems are arranged to connect the end node and the plurality of subflows.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: A method comprising: A) using a mobile device's camera to capture a first image; B) by reference to a first illumination source appearing in the first image, determining first heading information of the mobile device; C) as the mobile device moves to a second location, using one or more inertial sensors of the mobile device to extrapolate a plurality of extrapolated first candidate locations and respective first candidate headings of the mobile device; D) at the second location, using the camera to capture a second image; E) by reference to a second illumination source appearing in the second captured image, determining a plurality of second candidate locations and respective second candidate headings of the mobile device; and F) based on a comparison of the extrapolated first candidate locations and headings with the second candidate locations and headings, determining at least one estimated location and respective heading of the mobile device.

Abstract: The invention relates to a kinase inhibitor, in particular an inhibitor of protein kinases including the protein-tyrosine kinases LCK, ABL, SRC, KIT, SIK-family and/or their mutants. Although structurally similar to dasatinib, the kinase inhibitor of the invention displays, eg functional and ADMET properties distinct to dasatinib. Also, the invention relates to pharmaceutical compositions that comprise the kinase inhibitor, including those formulated for oral administration, such as in unit dose form that comprise particular ranges or amounts of the kinase inhibitor. The kinase inhibitor or pharmaceutical composition may be used in the treatment of a proliferative disorder, such as a leukaemia or solid tumour.

Abstract: A pneumatic tire is described which includes a tread, a carcass and a belt structure interposed between the carcass and the tread. The belt structure includes a first and second working belt, wherein the angle of the working belts range from about 12 degrees to about 35 degrees, wherein the belt structure further includes a low angle belt located radially inward of the working belts. The first working belt is the radially innermost working belt, and is the widest belt. The second working belt is the radially outermost belt. The pneumatic tire may further include a second optional low angle belt, that is located between the first low angle belt and the first working belt.

Abstract: The invention features a replaceable cartridge for a plasma arc torch. The cartridge includes a cartridge body having a first section and a second section. The first and second sections are joined at an interface to form a substantially hollow chamber. The interface provides a coupling force that secures the first and second sections together. The cartridge also includes an arc constricting member located in the second section; an electrode included within the substantially hollow chamber; and a contact start spring element affixed to the electrode. The spring element imparts a separating force that biases the electrode toward at least one of the first section or the second section of the body. The separating force has a magnitude that is less than a magnitude of the coupling force.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: A graphical block diagram can use an execution order block to enforce an execution order for parallel subtrees. A graphical data flow block diagram is generated that includes parallel subtrees. The parallel subtrees can be connected to input pins of the execution order block in the execution order. The parallel subtrees are processed in the execution order before other blocks connected to the parallel subtrees are processed according to the normal execution order of the graphical program. The execution order of the execution order block is not affected by the other blocks, and the normal execution order of the other blocks according to the graphical program is not affected by the execution order of the execution order block. The techniques described herein improve a model-based development platform.

Abstract: Analysis and graphical rendering of subscriber data is provided. A data analysis component is provided that obtains a set of subscriber data, correlates various subsets of the subscriber data to determine a plurality of data relationships, and graphical renders the subscriber data as a heat map, a fractal map, a tree map, a three dimensional plot, a three dimensional map, a graph, a chart, etc. based on a scale associated with the data relationships. In addition, the data analysis component can obtain a set of line number portability data that can be correlated with the various subsets of the subscriber data to determine the data relationships.

Abstract: A method for pooling a plurality of shipments of less than full truckloads of freight to create a full truckload while providing a full truckload service level guarantee includes receiving a request for a first shipment of less than a full truckload of freight between an origin and a destination by a specified delivery date in accordance with a level of service guaranteed for a full truckload of freight. The method includes providing a commitment to ship the shipment as requested. The method includes receiving, after providing the commitment to ship the shipment for the first shipper, a request from a second shipper for delivery of a second shipment of less than a full truckload of freight. The method includes determining to combine the first shipment and the second shipment into a full truckload of freight.

Abstract: A system and method for using weather applied metrics for determining the impact of weather conditions on the flight of a ball at an outdoor sports venue. Historical and current data for weather parameters, including wind, air pressure, humidity, temperature, and precipitation, are obtained to calculate the influence of each parameter on the flight of a ball. The influences of each of the parameters are summed to model the flight of the ball based on the current weather conditions. Weather instruments, such as weather sensors, anemometers, LiDAR and SODAR devices, weather consoles, data routing devices, and processors can be included in a system for using weather applied metrics to predict the flight of a ball based on current weather conditions.

Abstract: A method of delivering tumor treating electric fields to a body of a patient. The method includes scanning the body of the patient for identifying at least two tumor-filled areas. The method further includes determining a spatial relationship in between the at least two tumor-filled areas. The method further includes arranging an array of insulated electrode elements on the body of the patient. The method further includes implementing at least two subarray firing configurations for the array of insulated electrode elements to treat the at least two tumor-filled areas depending at least in part upon the spatial relationship in between the at least two tumor-filled areas such that each subarray firing configuration treats a respective tumor-filled area.

Abstract: A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets, a cuff at least partially disposed on a luminal surface of the stent, and a covering material disposed on an abluminal surface of the stent and covering the at least one runner in the second configuration.

Abstract: Various opacifying adhesive compositions are described. The adhesives exhibit relatively high levels of opacity in wet conditions while maintaining acceptable adhesive properties. Also described are label assemblies and labeled containers using such adhesives. Related methods of use and preparation are also described.

Abstract: Attachments for excavators and the like for improved gripping, handling, and processing of materials and debris are provided having one or more work surfaces to provide enhanced material handling characteristics.

Abstract: A microenvironment of a biological body is controlled, and more particularly, is measured, changed, and monitored with respect to temperature, pH level, moisture and other tissue parameters of a region of the body while, optionally, administering a therapeutic agent to that region.

Abstract: A compound of formula (I) or an N-oxide, a salt, a hydrate, a solvate, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer for use in the treatment or prophylaxis of brain ischemia, ischemic brain injury, Ischemic Stroke (IS), haemorrhagic stroke, traumatic brain injury, spinal cord injury.