Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and CD123. The invention also relates to pharmaceutical compositions comprising said antibody-like binding protein and the use of said pharmaceutical compositions and antibody-like binding protein to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein.

Abstract: A surgical instrument includes an elongated shaft having a proximal structural member and a proximal drive member that is selectively movable with respect to the proximal structural member. A modular end effector is removably coupled to the elongated shaft, and has a distal structural member and a distal drive member that is operatively coupled to a pair of jaw members. A separable joint is defined between the elongated shaft and the end effector. The separable joint includes laterally prominent and laterally indented portions of each of the proximal and distal structural members and of each of the proximal and distal drive members. The structural members are interlocked to resist longitudinal separation and permit lateral separation. The drive members are movable relative to structural members to move the separable joint to a locked configuration wherein the drive members prohibit lateral separation of the structural members.

Abstract: A transmitter is configured to convey N bits of information and L bits of information, for a total of N+L bits of information, to a destination device via an auxiliary device. The transmitter is configured to select, from a plurality of auxiliary devices that are respectively associated with different possible states of the L bits of information, an auxiliary device that is associated with a state of the L bits of information to be conveyed. L may be ?1. The transmitter is also configured to convey the N+L bits of information from the transmitter to the destination device via the selected auxiliary device, without the transmitter transmitting any of the L bits of information to the destination device or the selected auxiliary device, by transmitting a signal to the selected auxiliary device. This signal comprises the N bits of information. N may be ?0.

Abstract: A semiconductor device includes a plurality of gate trenches formed in a first surface of a semiconductor body and extending lengthwise parallel to one another, transistor cells and diode regions formed in a mesa of the semiconductor body between neighboring ones of the gate trenches, and a drift region in the semiconductor body beneath the gate trenches. Each transistor cell includes a source zone and a body region. Each diode region includes a contact portion and a lower doped shielding portion. The source zone forms a first p-n junction with the body region, and the body region forms a second p-n junction with the drift region. The contact region extends to the first surface, and the shielding portion forms a third p-n junction with the drift region. The shielding portion extends under bottoms of the neighboring ones of the gate trenches.

Abstract: The disclosed systems and methods provide organization, small group, and particularly family-oriented communications platforms, with computing device applications and services allowing users to post, store, organize and share transactions, events, stories, updates, conversations, photos, physical location information and videos and other small group shared, or family-related, information within specified small group units, including specified family units. A content-controlled data and information exchange environment, as a local unit network, is provided that effectively firewalls content providers from gaining insight into the information exchanged by, and preferences of, any individual member of the group, while maintaining transparency into the interests, goals, objectives and data exchange preferences of the group. These objectives are implemented via a specific communications gateway between the local group network and external communication nodes.

Abstract: A retainer device for removably connecting a first tote to a second tote in a stacked arrangement includes an elongated body member including a top surface, a bottom surface, and a channel disposed in the bottom surface and extending along a length of the elongated body member. There is a leg member affixed to the elongated body member at a first angle with respect to the top surface of the elongated body member and extending at least partially along the length of the elongated body member. There is also at least one foot member having a top surface; the at least one foot member affixed to the leg member at a second angle such that the top surface of at least one foot member faces the bottom surface of the elongated body member to define a region for receiving portions of the first and second totes.

Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.

Abstract: Disclosed herein is a magnetic storage device that comprises a suspension arm co-movably fixed to a carriage arm. The suspension arm comprises a slider attachment side and at least one first electrical contact pad on the slider attachment side. The suspension arm also comprises a slider co-movably fixed to the suspension arm. The slider comprises a suspension attachment side, a non-head side facing the suspension arm and intersecting the suspension attachment side at a first slider edge of the slider, a head side facing away from the suspension arm, and at least one electrical contact component on the suspension attachment side up to the first slider edge. At least one solder weldment is directly coupled to the at least one first electrical contact pad and the at least one electrical contact component. Additionally, a read-write head is coupled to the head side of the slider.

Abstract: A data center may include a tape library rack module along with rack computer systems. The rack computer systems may be configured to provide computing capacity within a data center environment. In some embodiments, the tape library rack module may include an enclosure encompassing an interior of the tape library rack module, a rack within the interior, and a tape library unit mounted on the rack. The tape library rack unit may include tape cartridges configured to store data within a tape environment that is different than the data center environment. The tape library rack unit may be within a portion of the interior that is enclosed such that it is environmentally isolated from the data center environment. In some examples, the tape library rack module may include a cooling unit and/or a humidifier unit, which may provide the tape environment to the environmentally isolated portion of the interior of the tape library rack module.

Abstract: The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.

Abstract: A resettable pressure activated device (100), comprises an inner wall (102), a return spring (105), a resilient element (110) and an axially movable piston (120) arranged around the inner wall (102). The piston (120) comprises a radially extending piston area (121) in fluid communication with a central bore (101) within the inner wall (102) such that the piston (120) moves in an activation direction when a bore pressure within the central bore (101) exceeds the pressure around the device by a predetermined release pressure. The return spring (105) is configured to provide a return force that is directed opposite the activation direction and has a magnitude sufficient to return the piston (120) to an idle position when the bore pressure drops below a predetermined reset level. The resilient element (110) provides a retaining force, e.g. a friction force, equal to the difference between the release force and the return force.

Abstract: A rotary vacuum pump includes a housing defining a pump chamber therein and a rotor extending through a first axial end panel into the pump chamber and carrying at least one vane for rotary movement of the vane within the pump chamber. The rotor comprises an annular axial end face configured to seal against a corresponding contact surface of a second axial end panel. An annular groove for reducing noise generation of the rotary vacuum pump during operation is formed at the annular axial end face of the rotor and/or the contact surface of the second axial end panel.

Abstract: The UNIVERSAL ELECTRONIC PAYMENT APPARATUSES, METHODS AND SYSTEMS (“UEP”) transform touchscreen inputs into a virtual wallet mobile application interface via UEP components into purchase transaction triggers and receipt notices. In one implementation the UEP provides, via a user device, a product information search request; and obtains, in response to the product information search request, information on a first product for sale by a first merchant and a second product for sale by a second merchant. The UEP generates a single purchase transaction request, using the information on the first product for sale by the first merchant and the second product for sale by the second merchant. The UEP provides, via the user device, the single purchase transaction request for payment processing. Also, the UEP obtains an electronic purchase receipt for the first product for sale by the first merchant and the second product for sale by the second merchant.

Abstract: A method of filling a cartridge with medical gas, including removably sealing a sealing mechanism against the open end of an uncapped and empty cartridge, fluidically attaching an evacuation adapter to the sealing mechanism and evacuating the cartridge, thus producing at least a partial vacuum therein, fluidically attaching a fill adapter to the sealing mechanism and filling the cartridge with medical gas at a predetermined pressure and temperature, and fluidically attaching a capping device to the sealing mechanism and while maintaining the predetermined pressure and temperature capping the cartridge is presented.

Abstract: An apparatus for filling a cartridge with medical gas, comprising a sealing mechanism designed to removably seal against the open end of an uncapped and empty cartridge, evacuate the cartridge, producing at least a partial vacuum therein, fill the cartridge with medical gas at a predetermined pressure and temperature, and maintain the predetermined pressure and temperature while the cartridge is capped is presented.

Abstract: A cap for fastening a denture on an anchoring element has a projecting part pointing radially inwards which co-operates with a circumferential groove on the anchoring element, thus forming a retention element such that the cap can be releasably fastened on the anchoring element. The cap has a conical end portion located below the retention element, the end portion at least partially surrounding, in the fastened state, a corresponding outer surface of the anchoring element.

Abstract: The invention concerns a process for manufacturing a dry mineral pigment containing a product formed in situ by the multiple reaction between a calcium carbonate and the product or products of reaction of the said carbonate with one or more moderately strong to strong H3O+ ion donators and the product or products of reaction of the said carbonate with gaseous CO2 formed in situ and/or originating from an external supply and one or more compounds of formula R—X together with the mineral pigment obtained by the process, and its applications in the field of paint and/or plastics.

Abstract: The invention relates to a system for providing images for detecting an endoleak after a stent graft has been placed within the aorta of a person at a stent graft location. First and second contrast agents are injected at first and second times (T1, T2) and first, second and third computed tomography images of the stent graft location showing a) the first contrast agent, b) the second contrast agent and c) the stent graft and tissue, respectively, are reconstructed based on spectral projection data acquired at a third time (T3). By using these computed tomography images for detecting an endoleak, the endoleak detection can be significantly improved, wherein this improved endoleak detection can be provided with a relative low radiation dose, because the images can be reconstructed by using only the computed tomography scan at the third time.

Abstract: According to one aspect, a guidewire assembly for positioning within a body of a patient may include a guidewire shaft having a proximal section and a distal section. The distal section may be configured to move within the body of a patient when the guidewire assembly is in a first operating state. The distal section may be configured to expand radially outward when the guidewire assembly is in a second operating state to engage an interior surface of the body and inhibit movement of the guidewire shaft.

Abstract: Herbicidal dispersible concentrates include an herbicide and substantially water miscible amide-based solvents. Such concentrates may be diluted in water and used in methods to control weeds.