Patents by Inventor Peter P. Gombrich
Peter P. Gombrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230107635Abstract: The present disclosure provided methods, devices, and systems for CRISPR-based screening and detection of HPV-related diseases. In particular, the present disclosure provides a CRISPR-Cas assay for rapid, enhanced screening of cervical intraepithelial neoplasia (CIN) and cancer, which can also be applied to screening for other HPV-related anogenital or head and neck cancers, whose origin is based on infections with high-risk strains of human papillomavirus (hr-HPV).Type: ApplicationFiled: September 29, 2022Publication date: April 6, 2023Inventors: Paul VICHI, Peter P. GOMBRICH
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Publication number: 20220160340Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.Type: ApplicationFiled: February 11, 2022Publication date: May 26, 2022Inventors: Peter P. GOMBRICH, Christopher E. TODD
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Patent number: 11246577Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.Type: GrantFiled: March 10, 2017Date of Patent: February 15, 2022Assignee: ONCOGENESIS, INC.Inventors: Peter P. Gombrich, Christopher E. Todd
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Publication number: 20220026430Abstract: Devices and methods described herein provide improved methods of screening for cervical disease. In certain embodiments, a sample transfer and preparation vial is provided, enabling self-collection and pre-processing of cervical samples to expedite sample processing and eliminate the need for a patient to travel to a medical facility for screening. In certain embodiments, an analysis cartridge having a multiplexed biomarker panel and an immunoassay-based analyzer are provided for sample analysis. The multiplexed biomarker panel provides high sensitivity and specificity to enable effective screening with a single procedure and thus, eliminates the need for multiple tests. In certain embodiments, a method of screening for cervical disease is provided, utilizing the aforementioned multiplexed biomarker panel.Type: ApplicationFiled: July 26, 2021Publication date: January 27, 2022Inventors: Paul VICHI, Peter P. GOMBRICH
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Patent number: 10670595Abstract: Systems and methods for detection of analytes by production of electrochemical species are provided. Some embodiments of this invention relate generally to carbon biosensors for detecting an analyte in a biological sample. More specifically, this invention relates generally to immunoassays for detection of analytes utilizing electroactive compounds, and more particularly, relates to diagnostic assays based on signals from electroactive chemical undergoing redox cycling on electrosensor consisting of carbon, to detect analytes wherein a precomplex mixture is formed and a multi-step, or single-step, assay is performed, resulting in greater signal.Type: GrantFiled: May 26, 2016Date of Patent: June 2, 2020Assignee: OncoGenesis, Inc.Inventors: Peter P. Gombrich, Nam W. Kim, Christopher E. Todd
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Publication number: 20180164300Abstract: Systems and methods for detection of analytes by production of electrochemical species are provided. Some embodiments of this invention relate generally to carbon biosensors for detecting an analyte in a biological sample. More specifically, this invention relates generally to immunoassays for detection of analytes utilizing electroactive compounds, and more particularly, relates to diagnostic assays based on signals from electroactive chemical undergoing redox cycling on electrosensor consisting of carbon, to detect analytes wherein a precomplex mixture is formed and a multi-step, or single-step, assay is performed, resulting in greater signal.Type: ApplicationFiled: May 26, 2016Publication date: June 14, 2018Inventors: Peter P. Gombrich, Nam W. Kim, Christopher E. Todd
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Publication number: 20180028164Abstract: A cervical cell collection device, kit and method for the collection of cervical cells is provided. In some embodiments, the cervical cell collection device comprises an outer guide assembly having a distal end section with an aperture there through; an inner assembly positioned within the outer guide assembly, the inner assembly having a distal end with a collapsible collection pad secured thereto by a flexible collection support, wherein the inner assembly is movable from a first position where the collection pad is folded inside distal end section of the outer guide assembly to a second position where the collection pad is pushed through the aperture in the distal end of the outer guide assembly where it expands to contact and collect cervical cells.Type: ApplicationFiled: March 10, 2017Publication date: February 1, 2018Inventors: Peter P. Gombrich, Christopher E. Todd
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Publication number: 20040002125Abstract: Cellular samples such as cervical cells can be analyzed using a unique combination of markers that identify abnormal cells while subtracting out false positives that would otherwise be generated by, for example, normally proliferating cells and non-cellular debris. Dysplastic cervical cells can thus be identified quickly and accurately. An assay including analytical reagents and methods of their use can be employed in classifying cervical cytology specimens as being normal or abnormal. This assay is configured to be performed using any of several commonly available classes of laboratory instrumentation and upon the entire range of cervical cytology specimen preparations encountered in clinical practice. This assay is particularly intended for use in high volume screening environments, but also has both diagnostic and research applications.Type: ApplicationFiled: November 14, 2002Publication date: January 1, 2004Inventors: Peter P. Gombrich, Matthew Gombrich, Susan Keesee, Dan Kusswurm, Didier Adehl, Jennifer Kawaguchi, Richard A. Domanik
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Patent number: 6663576Abstract: A system for accurately obtaining cervical cells from a patient and quickly screening the sample includes a collector for collecting a spatially arranged cell sample from a target tissue, and an analyzer that examines the cell sample for abnormal cells while the cell sample remains on a surface of the collector.Type: GrantFiled: November 29, 2000Date of Patent: December 16, 2003Assignee: Molecular Diagnostics, Inc.Inventors: Peter P. Gombrich, Richard A. Domanik, George Gorodeski
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Patent number: 6475164Abstract: Cervical cells can be sampled in such a way as to retain the spatial relationships that existed between the cells prior to sampling. The cells can be collected by using a cervical cell collector that samples a cervix in a spatially resolved manner. The cervix is sampled by placing a sampling balloon in position adjacent to a cervix and inflating the sampling balloon to force a sampling surface of the sampling balloon into contact with the cervix, thereby transferring cervical cells from the cervix to the sampling surface of the sampling balloon. The sampling balloon is then deflated and withdrawn. Then, the adhered cervical cells are treated with a marker and are optically analyzed.Type: GrantFiled: November 29, 2000Date of Patent: November 5, 2002Assignee: Ampersand Medical CorporationInventors: Peter P. Gombrich, Richard A. Domanik, George Gorodeski
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Publication number: 20020130074Abstract: A cellular sample can be optically analyzed while present on a membrane filter. A membrane filter is designed to collect and adhere cells and other cellular material while permitting fluids to pass. The cellular sample can be processed mechanically or manually in order to provide cells adhered to the membrane filter. The cellular sample can be obtained through lavage, by using a personal or physician's collector, or through traditional PAP test techniques. The cellular sample can include vaginal, cervical, or ovarian tissue cells.Type: ApplicationFiled: October 15, 2001Publication date: September 19, 2002Inventors: Richard A. Domanik, Peter P. Gombrich
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Publication number: 20020106718Abstract: Cellular samples such as cervical cells can be obtained from a cell suspension and then transferred to a microscope slide for analysis. The cells can be retrieved from the cell suspension using an inexpensive, easy to use device that requires no instruments or ancillary devices, minimal operator skill and training, and is potentially sufficiently low cost that it is suitable for use in mass screening programs.Type: ApplicationFiled: December 4, 2001Publication date: August 8, 2002Applicant: MOLECULAR DIAGNOSTICS, INC.Inventors: Peter P. Gombrich, Richard A. Domanik
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Publication number: 20020087096Abstract: A cervical cell collection device can easily and comfortably be used by a woman in the privacy and comfort of her own home. Once the woman obtains the cervical cell sample, she can be forward it to a physician's office or other lab location for analysis. The collection device includes an outer guide assembly and an inner sampling assembly bearing a collector.Type: ApplicationFiled: February 11, 2002Publication date: July 4, 2002Applicant: MOLECULAR DIAGNOSTICS, INC.Inventors: David M. Anderson, Peter P. Gombrich, Richard A. Domanik
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Patent number: 6352513Abstract: A cervical cell collection device can easily and comfortably be used by a woman in the privacy and comfort of her own home. Once the woman obtains the cervical cell sample, she can be forward it to a physician's office or other lab location for analysis. The collection device includes an outer guide assembly and an inner sampling assembly bearing a collector.Type: GrantFiled: June 26, 2000Date of Patent: March 5, 2002Assignee: Ampersand Medical CorporationInventors: David M. Anderson, Peter P. Gombrich, Richard A. Domanik
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Publication number: 20010047136Abstract: An in-vivo tissue inspection device provides for increased signal levels and the ability to discriminate between normal and abnormal tissues through the use of an exogenous fluorescent or fluorogenic reagent. The device reduces the costs of in-situ fluorescent measurements for screening and diagnostic purposes by eliminating the need for an imaging endoscope; simplifying the illuminating and detection means used in the device; and reducing the computing power needed for data reduction; reducing the operator skill level required to make quantitative measurements of in-situ fluorescence, and enabling simultaneous sampling of the ectocervix and the endocervical canal.Type: ApplicationFiled: January 22, 2001Publication date: November 29, 2001Inventors: Richard A. Domanik, Peter P. Gombrich
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Publication number: 20010029029Abstract: Cellular samples can be evaluated in a manner in which the spatial relationships existing between said cells in-vivo are preserved and can be used to guide subsequent follow-up and treatment where abnormalities are detected. An instrument for analyzing cervical cells includes receiving means for receiving a topological array of cervical cells, reagent application means for applying one or more reagents to the topological array of cervical cells, analysis means for optically analyzing the topological array of cervical cells, and reporting means for reporting results of the analysis means.Type: ApplicationFiled: November 29, 2000Publication date: October 11, 2001Inventors: Peter P. Gombrich, Richard A. Domanik, George Gorodeski
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Publication number: 20010029044Abstract: A system for accurately obtaining cervical cells from a patient and quickly screening the sample includes a collector for collecting a spatially arranged cell sample from a target tissue, and an analyzer that examines the cell sample for abnormal cells while the cell sample remains on a surface of the collector.Type: ApplicationFiled: November 29, 2000Publication date: October 11, 2001Inventors: Peter P. Gombrich, Richard A. Domanik, George Gorodeski
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Publication number: 20010023321Abstract: Cervical cells can be sampled in such a way as to retain the spatial relationships that existed between the cells prior to sampling. The cells can be collected by using a cervical cell collector that includes sampling means for sampling a cervix in a spatially resolved manner, supporting means for supporting the sampling means, and inflation means for reversibly inflating and deflating the sampling means. The cervix is sampled by placing a sampling balloon in position adjacent to a cervix and inflating the sampling balloon to force a sampling surface of the sampling balloon into contact with the cervix, thereby transferring cervical cells from the cervix to the sampling surface of the sampling balloon. The sampling balloon is then deflated and withdrawn. Then, the adhered cervical cells are treated with a marker and are optically analyzed.Type: ApplicationFiled: November 29, 2000Publication date: September 20, 2001Inventors: Peter P. Gombrich, Richard A. Domanik, George Gorodeski
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Patent number: 6118581Abstract: A machine, method and medium for implementing functions using an input device in a manner that enhances efficient operation of a mechanism capable of operating in at least two states. The functions are implemented via a convenient input device, such as a mouse. One or more specified actuators of the input device implement a given function when the mechanism is in a first state, while at least one of those actuators implements a different function when the mechanism is in a second state. In embodiments of the present invention contemplating that the mechanism is a microscope system, two states in which the microscope system is envisioned to operate are a scan state and a pause state. The scan state allows the microscope system to execute a pre-defined scan sequence, while the pause state allows the microscope system to pause from that sequence.Type: GrantFiled: December 18, 1996Date of Patent: September 12, 2000Assignee: AccuMed International, Inc.Inventors: Richard A. Domanik, Dennis W. Gruber, Peter P. Gombrich, William J. Mayer
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Patent number: 6081740Abstract: A method and apparatus for imaging body tissue utilizing autofluorescence. The apparatus includes an endoscope having a distal end, proximal end and a light processing unit located at the proximal end of the endoscope. The light processing unit accepts light in a spectral region from a light source and directs the light through the endoscope to the tissue located at the distal end of the endoscope. The light excites autofluorescence in the tissue. Optics located in the distal end of the endoscope collect the excited autofluorescence in a spatially resolved manner and routes it to the light processing unit which separates the emitted light from any reflected excitation light. A plurality of imaging detectors receive the emitted light. Each imaging detector is responsive to light in a different spectral band such that an image is generated and interpreted according to a plurality of independent measurements. An apparatus for sampling tissue includes an endoscopic device having a sampling device.Type: GrantFiled: October 15, 1997Date of Patent: June 27, 2000Assignee: AccuMed International, Inc.Inventors: Peter P. Gombrich, Norman J. Pressman, Richard Domanik