Patents by Inventor Peter P. Roller

Peter P. Roller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serine protease inhibitors
    Patent number: 7439226
    Abstract: The present disclosure concerns peptides and peptidomimetics having inhibitory activity against serine proteases. The disclosed peptides and peptidomimetics are particularly useful as selective inhibitors of matriptase and MTSP1. Pharmaceutical compositions comprising serine protease inhibitors and methods for administering the compositions also are disclosed.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: October 21, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Peter P. Roller, Peng Li
  • Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
    Patent number: 7259142
    Abstract: A compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC50 in vivo of less than about 4.0 ?M with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: August 21, 2007
    Assignee: The United States of America, represented by the Secretary, Department of Health and Human Services
    Inventors: Peter P Roller, Ya-Qui Long, Feng-Di T. Lung, C. Richter King, Dajun Yang, Johannes H. Voigt
  • Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
    Patent number: 6951915
    Abstract: A compound of formula: in which L is sulfur, sulfoxide, oxygen or methylene, and a compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compounds (and their conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, are non-phosphorylated, are redox-stable in vivo, are characterized by an IC50 in vivo of less than about 4.0 ?M with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, have a turn conformation.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: October 4, 2005
    Assignees: The United States of America as represented by the Department of Health and Human Services, Georgetown University
    Inventors: Peter P. Roller, Ya-Qiu Long, Feng-Di T. Lung, C. Richter King, Dajun Yang
  • Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use
    Publication number: 20030078368
    Abstract: A compound of formula: 1
    Type: Application
    Filed: November 30, 2001
    Publication date: April 24, 2003
    Applicant: The Govt. of the United States of America
    Inventors: Peter P. Roller, Ya-Qiu Long, Feng-Di T. Lung, C. Richter King, Dajun Yang
  • Nitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising same
    Patent number: 6379660
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2− functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: April 30, 2002
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu
  • Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
    Patent number: 6200558
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2− functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: March 13, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu
  • Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
    Patent number: 5632981
    Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: May 27, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu