Patents by Inventor Peter Paulicka
Peter Paulicka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12280375Abstract: An acoustophoresis device having a sample vessel and a piezo transducer is described. The sample vessel has an outer surface, a microchannel within confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel, such that a blood sample is insertable through the first port into the microchannel. The sample vessel has conductive traces on the outer surface. The piezo transducer is bonded to the outer surface of the sample vessel to form a monolithic structure. The piezo transducer contacts at least one of the conductive traces, the piezo transducer is configured to generate ultrasonic waves inside a sample in the microchannel. The piezo transducer has an excitation signal input and response signal output electrically connected to the at least one of the conductive traces.Type: GrantFiled: October 10, 2022Date of Patent: April 22, 2025Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Jeffrey Jasperse, Peter Paulicka, Michael Palombo, Ramona Seliger, Paul Benson
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Publication number: 20250108379Abstract: The present disclosure relates to a device comprising a container having an inner wall and at least one opening, containing a mixture containing at least one reagent, and at least one additive, a method of producing this device, and a method of extracting a substance from a sample, enriching a substance in a sample, and/or detecting a substance in a sample using the device.Type: ApplicationFiled: December 12, 2024Publication date: April 3, 2025Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Walter Gumbrecht, Yiwei Huang, Peter Paulicka
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Publication number: 20240416346Abstract: An acoustophoresis device having a sample vessel and a piezo transducer is described. The sample vessel has an outer surface, a microchannel within confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel, such that a blood sample is insertable through the first port into the microchannel. The sample vessel has conductive traces on the outer surface. The piezo transducer is bonded to the outer surface of the sample vessel to form a monolithic structure. The piezo transducer contacts at least one of the conductive traces, the piezo transducer is configured to generate ultrasonic waves inside a sample in the microchannel. The piezo transducer has an excitation signal input and response signal output electrically connected to the at least one of the conductive traces.Type: ApplicationFiled: October 10, 2022Publication date: December 19, 2024Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Jeffrey Jasperse, Peter Paulicka, Michael Palombo, Ramona Seliger, Paul Benson
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Publication number: 20240385096Abstract: The disclosure relates to a method (100) of optically analyzing a blood cell from a blood sample with a device for optically analyzing a blood cell from a blood sample, the device (1) comprising a microfluidic chamber with at least one fluidic flow-through channel, a first inlet (6) port configured to introduce at least a part of the blood sample into the fluidic channel, a first outlet (7) port configured to discharge at least a part of the blood sample from the fluidic channel, a flow generating and stopping device configured to generate a flow of the sample through the channel and to stop the flow while a least a part of the sample comprising at least one blood cell is situated within the channel and wherein after stopping the flow the sample is only influenced by gravity and inertial forces such that blood cells within the sample sediment on a first area of a lower surface of the channel, wherein cells sedimented within the first area of the lower surface can be optically analyzed in the chamber.Type: ApplicationFiled: September 23, 2022Publication date: November 21, 2024Inventors: Ramona Seliger, Martin Kraus, Peter Paulicka, Tivadar Mach
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Publication number: 20240361211Abstract: A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.Type: ApplicationFiled: June 10, 2024Publication date: October 31, 2024Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Jeffrey R. Jasperse, Peter Paulicka, Paul Benson
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Publication number: 20240345102Abstract: The disclosure relates to a device and method for analyzing a blood sample, particularly including pre-analytical (qualification), analytical and post-analytical (verification) testing. More particularly the disclosure relates in certain embodiments to a device configured for collecting, imaging and lysing blood cells in a sample vessel by means of ultrasonic acoustic waves, generated in the vessel by an acoustic transducer driven at one particular excitation frequency or more particular excitation frequencies, or one range of frequency or ranges of frequencies. In some non-limiting embodiments, the ultrasonic acoustic waves are generated by a single acoustic transducer. Further on, according to certain embodiments, the device and workflow are configured for three analytical steps in single device, comprising pre-analytical (qualification), analytical and post-analytical (verification) testing.Type: ApplicationFiled: August 5, 2022Publication date: October 17, 2024Inventors: Tivadar Mach, Peter Paulicka, Ramona Seliger, Frederick Stelling
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Patent number: 12031890Abstract: A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.Type: GrantFiled: July 23, 2021Date of Patent: July 9, 2024Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Jeffrey R. Jasperse, Peter Paulicka, Paul Benson
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Publication number: 20230213414Abstract: A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.Type: ApplicationFiled: July 23, 2021Publication date: July 6, 2023Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Jeffrey R. Jasperse, Peter Paulicka, Paul Benson
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Publication number: 20220355294Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.Type: ApplicationFiled: July 25, 2022Publication date: November 10, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Peter Paulicka, Jeffrey Jasperse
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Patent number: 11426727Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.Type: GrantFiled: April 26, 2021Date of Patent: August 30, 2022Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Peter Paulicka, Jeffrey Jasperse
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Publication number: 20220143611Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.Type: ApplicationFiled: April 26, 2021Publication date: May 12, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Peter Paulicka, Jeffrey Jasperse
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Patent number: 11327048Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.Type: GrantFiled: March 20, 2020Date of Patent: May 10, 2022Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Ryan Irving, Peter Paulicka
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Publication number: 20220091068Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.Type: ApplicationFiled: March 20, 2020Publication date: March 24, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Ryan Irving, Peter Paulicka
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Patent number: 10816563Abstract: A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.Type: GrantFiled: August 9, 2018Date of Patent: October 27, 2020Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Walter Gumbrecht, Peter Paulicka
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Publication number: 20200188910Abstract: The present invention relates to a device comprising a container having an inner wall and at least one opening, containing a mixture containing at least one reagent, and at least one additive, a method of producing this device, and a method of extracting a substance from a sample, enriching a substance in a sample, and/or detecting a substance in a sample using the device.Type: ApplicationFiled: April 24, 2018Publication date: June 18, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Walter Gumbrecht, Yiwei Huang, Peter Paulicka
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Patent number: 10514353Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.Type: GrantFiled: May 20, 2019Date of Patent: December 24, 2019Assignee: Siemens AktiengesellschaftInventors: Walter Gumbrecht, Peter Paulicka
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Patent number: 10421988Abstract: The method includes binding living cells to magnetic particles, adding them to a sensor array, uniformly distributing over the sensor array, magnetically fixing the magnetic particles having the bound cells over the sensor array, and adding substances to maintain and/or improve the cell vitality to the sensory array, and/or adding substances to worsen the cell vitality to the sensor array. The assembly includes a sensor array composed of sensors, which are designed to be in direct fluidic contact with a fluid, and a device for generating a magnetic field over the sensor array. A layer that comprises magnetic particles and living cells is formed on the sensor array.Type: GrantFiled: September 29, 2010Date of Patent: September 24, 2019Assignee: SIEMENS AKTIENGESELLSCHAFTInventors: Walter Gumbrecht, Markus Klöpzig, Peter Paulicka, Harald Schmidt, Manfred Stanzel
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Publication number: 20190271657Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.Type: ApplicationFiled: May 20, 2019Publication date: September 5, 2019Inventors: Walter Gumbrecht, Peter Paulicka
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Patent number: 10359388Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.Type: GrantFiled: January 21, 2013Date of Patent: July 23, 2019Assignee: Siemens AktiengesellschaftInventors: Walter Gumbrecht, Peter Paulicka
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Patent number: 10184946Abstract: A method for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involve the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.Type: GrantFiled: August 18, 2015Date of Patent: January 22, 2019Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Walter Gumbrecht, Peter Paulicka