Patents by Inventor Peter Paulicka

Peter Paulicka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230213414
    Abstract: A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.
    Type: Application
    Filed: July 23, 2021
    Publication date: July 6, 2023
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jeffrey R. Jasperse, Peter Paulicka, Paul Benson
  • Publication number: 20220355294
    Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.
    Type: Application
    Filed: July 25, 2022
    Publication date: November 10, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Peter Paulicka, Jeffrey Jasperse
  • Patent number: 11426727
    Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: August 30, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Peter Paulicka, Jeffrey Jasperse
  • Publication number: 20220143611
    Abstract: Lysis devices, methods, and systems are disclosed including a lysis device comprising a sample vessel having an outer surface, a microchannel within the confines of the outer surface, a first port extending through the outer surface to the microchannel, and a second port extending through the outer surface to the microchannel; and an acoustic transducer bonded to the outer surface of the sample vessel to form a monolithic structure, the acoustic transducer configured to emit ultrasonic acoustic waves into and/or to induce shear forces into a blood sample within the microchannel, thereby rupturing the blood cells.
    Type: Application
    Filed: April 26, 2021
    Publication date: May 12, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Peter Paulicka, Jeffrey Jasperse
  • Patent number: 11327048
    Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 10, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan Irving, Peter Paulicka
  • Publication number: 20220091068
    Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.
    Type: Application
    Filed: March 20, 2020
    Publication date: March 24, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan Irving, Peter Paulicka
  • Patent number: 10816563
    Abstract: A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: October 27, 2020
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Publication number: 20200188910
    Abstract: The present invention relates to a device comprising a container having an inner wall and at least one opening, containing a mixture containing at least one reagent, and at least one additive, a method of producing this device, and a method of extracting a substance from a sample, enriching a substance in a sample, and/or detecting a substance in a sample using the device.
    Type: Application
    Filed: April 24, 2018
    Publication date: June 18, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Walter Gumbrecht, Yiwei Huang, Peter Paulicka
  • Patent number: 10514353
    Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: December 24, 2019
    Assignee: Siemens Aktiengesellschaft
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Patent number: 10421988
    Abstract: The method includes binding living cells to magnetic particles, adding them to a sensor array, uniformly distributing over the sensor array, magnetically fixing the magnetic particles having the bound cells over the sensor array, and adding substances to maintain and/or improve the cell vitality to the sensory array, and/or adding substances to worsen the cell vitality to the sensor array. The assembly includes a sensor array composed of sensors, which are designed to be in direct fluidic contact with a fluid, and a device for generating a magnetic field over the sensor array. A layer that comprises magnetic particles and living cells is formed on the sensor array.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: September 24, 2019
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Walter Gumbrecht, Markus Klöpzig, Peter Paulicka, Harald Schmidt, Manfred Stanzel
  • Publication number: 20190271657
    Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Patent number: 10359388
    Abstract: An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: July 23, 2019
    Assignee: Siemens Aktiengesellschaft
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Patent number: 10184946
    Abstract: A method for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involve the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: January 22, 2019
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Publication number: 20180356434
    Abstract: A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
    Type: Application
    Filed: August 9, 2018
    Publication date: December 13, 2018
    Applicant: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Patent number: 10081831
    Abstract: A method is disclosed for calibrating a sensor element, which has an immobilized probe oligonucleotide, via which the bonding of a target nucleic acid (Z) can be detected by the sensor. In at least one embodiment, the method includes: a) bringing the sensor element into contact with a control nucleic acid (K), the melting temperature Tm(K) of which is less than the melting temperature Tm(Z) of the target nucleic acid (Z); b) hybridizing the control nucleic acid (K) to the probe oligonucleotide at a temperature T[p]<Tm(K), and detecting a positive control signal; and optionally c) modifying the stringent conditions such that T[n]>Tm(K) and detecting a negative control signal at a temperature T[n]. According to a refinement of at least one embodiment of the invention, a measuring signal of the target nucleic acid (Z) is measured at a measuring temperature T [mess], where Tm(K)<T[mess]<Tm(Z). The method is suited in particular for the calibration and quality control of microarrays.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: September 25, 2018
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Katja Friedrich, Walter Gumbrecht, Peter Paulicka, Manfred Stanzel, Renee Weber
  • Patent number: 10073107
    Abstract: A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatization of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: September 11, 2018
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Walter Gumbrecht, Peter Paulicka
  • Publication number: 20180185838
    Abstract: A biochemical analytical device and a biochemical analytical method for determining an analyte in a test sample are provided. In the technique, the biochemical analytical device includes a sample port to receive the test sample, a sensor to probe the test sample and to generate sensor data, and a processor. The sensor data corresponds to the analyte in the test sample. The processor receives the sensor data from the sensor and selects a non-linear function for the received sensor data. The processor fits the selected non-linear function to the sensor data. Additionally, the processor compares the fitted non-linear function to a reference data to determine the analyte in the test sample.
    Type: Application
    Filed: July 2, 2015
    Publication date: July 5, 2018
    Inventors: Ralph Grothmann, Walter Gumbrecht, Mark Matzas, Peter Paulicka, Stefanie Vogl, Hans-Georg Zimmermann
  • Patent number: 9995703
    Abstract: A device for detecting chemical or biochemical substances in fluids for use in an electrochemical camera. The device includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as the electrochemical camera.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: June 12, 2018
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Alexander Frey, Walter Gumbrecht, Peter Paulicka, Meinrad Schienle, Manfred Stanzel
  • Patent number: 9958435
    Abstract: A process is disclosed for detecting cells in a liquid sample, which includes: i) filtration of the liquid sample through a porous membrane which is suitable for retaining detectable cells, where at least one subregion of a support is configured as transparent supporting body and the membrane is arranged over its area on the transparent supporting body in such a way that detectable cells are retained on at least part of the surface of the membrane and that at least part of the sample liquid passes through the membrane, ii) application of a liquid optical medium which has essentially the same refractive index as the supporting body, and iii) optical measurement of at least a subarea of the membrane in order to detect detectable cells.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: May 1, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Joachim Bangert, Katja Friedrich, Walter Gumbrecht, Karsten Hiltawsky, Peter Paulicka, Manfred Stanzel
  • Patent number: 9766196
    Abstract: An apparatus for detecting liquids or substances from liquids in spatially separate reaction zones using a plug-in module or a chip card for rapid immunological tests, for example, with the help of a reading device. The liquids or substances from liquids are detected by a sensor array and on which at least one diaphragm is arranged. Individual sensors are spatially separated from each other on a plane by means of walls. The diaphragm is filled with liquid that is to be analyzed. Sealed reaction chambers are created when pressure is applied to the diaphragm. Pores in the diaphragm are completely closed in the zone of the walls while the pores are merely reduced in size and liquid can continue to be exchanged in zones directly above the sensors. No liquid can be exchanged between adjacent reaction chambers as long as pressure is applied to and compresses the diaphragm.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: September 19, 2017
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Walter Gumbrecht, Peter Paulicka, Manfred Stanzel