Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A holder for an inhaler article. The holder comprises a housing comprising a housing cavity. The holder further comprises an engagement member located at least partially within the housing cavity. The engagement member is movable relative to the housing between an upstream position and a downstream position. The engagement member comprised a first follower member. The housing comprises a first guide and a first latch, the first follower member is arranged to follow the first guide between a first position, a second position, and a third position. The first latch is arranged such that the first follower member may pass from the first position to the second position, but may not return to the first position without first passing the third position. An inhaler system comprises a holder and an inhaler article.

Abstract: Machine learning-based techniques for predicting trademark similarity are described. For instance, a first trademark pair comprising an attribute of a first trademark and a corresponding attribute of a second trademark is received. A level of similarity is determined between the first trademark pair and respective second trademark pairs included in respective legal proceedings maintained in a database. A subset of proceedings from the proceedings is selected, each proceeding of the subset including a respective second trademark pair that has the level of similarity with the first trademark pair. A feature vector is generated based on each proceeding of the subset. The feature vector is provided to a machine learning model that outputs a prediction score, based on the feature vector, as to whether a subsequent proceeding would find a likelihood of confusion between the first trademark and the second trademark. The prediction score is provided to a user interface.

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A hose retainer for spray hoses that uses a "U" shaped hose retainer that has a hollow interior. The hose retainer is sized to hold a fully retracted sprayer hose. The sprayer hose can be attached to a sprayer nozzle or to a removable faucet sprayer, found on modern sinks. A flange secures the hose retainer under the counter top. If needed, brackets can be installed near the bottom of the hose retainer to provide additional support. In this way, the hose can be stored within the hose retainer, removed for use, and replaced without exposing the sprayer hose to any of the under-sink plumbing or items that may be stored there.