Abstract: The present invention relates to specific binding molecules, such as T cell receptors (TCRs), that bind the HLA-A*02 restricted peptide KVLEYVIKV (SEQ ID NO: 1) derived from the germline cancer antigen MAGEA1. The specific binding molecules may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGEA1 TCR. The specific binding molecules of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: A portable fitness bench is provided. The device includes a lower platform. A container is affixed to an upper surface of the lower platform. The container includes a base portion hingedly affixed to a lid portion defining an interior volume. An upper platform is affixed to the lid portion, wherein the upper platform rests along a plane parallel to a plane of the lower platform when the container is in the closed position. A bench support is affixed to an upper side of the upper platform. A first leg is affixed to a lower surface of the lower platform at a first end thereof and a second leg is affixed to the lower surface of the lower platform at a second end thereof. A pair of wheels are affixed to the second end of the lower platform, and a handle is affixed to the first end of the lower platform.

Abstract: Embodiments of the present invention provide a concept for determining the relevance of a tag within a post. Responsive to receiving a post composed by a first user and containing a tag referring to a second user, a post context based on a topic of the post, a user context based on a record of the first user and a tag context based on a record of the second user are obtained. The post context and the user context are compared to the tag context, and it is determined whether the tag is relevant to the post and the first user based on comparing the post context and the user context to the tag context.

Abstract: A portable fitness bench is provided. The device includes a lower platform. A container is affixed to an upper surface of the lower platform. The container includes a base portion hingedly affixed to a lid portion defining an interior volume. An upper platform is affixed to the lid portion, wherein the upper platform rests along a plane parallel to a plane of the lower platform when the container is in the closed position. A bench support is affixed to an upper side of the upper platform. A first leg is affixed to a lower surface of the lower platform at a first end thereof and a second leg is affixed to the lower surface of the lower platform at a second end thereof. A pair of wheels are affixed to the second end of the lower platform, and a handle is affixed to the first end of the lower platform.

Abstract: A CCD structure (20) tolerant to the adverse formation of traps resulting from exposure to irradiation by particles such as protons and neutrons is described. The CCD comprises an image plane (22) having a number of parallel transfer channels. Path defining structures (24), such as barrier implants, define a principal electron flow path through the channel, and define a number of secondary paths which converge on the principal path. The paths ensure that signal charge generated across the entire width of the channel is collected together into regions of smaller area so that the likelihood of interaction with traps is reduced, and charge containment is maintained near the optimum for all signal levels up to the full well.