Patents by Inventor Peter Q. Nguyen

Peter Q. Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10995114
    Abstract: Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers thing films by, for example, disassembly and re-assembly, are disclosed herein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 4, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne, Anna M. Duraj-Thatte, Peter Q. Nguyen
  • Publication number: 20200308577
    Abstract: Disclosed herein are hydrogels comprising a polynucleotide-based structural component. Methods of altering a property of a hydrogel based on user-defined nucleic acid input sequences are also disclosed. In addition, various applications are described that utilize these hydrogels and methods.
    Type: Application
    Filed: January 31, 2020
    Publication date: October 1, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: James J. Collins, Helena de Puig Guixe, Luis Soenksen Martinez, Max English, Raphael Gayet, Nicolaas Angenent-Mari, Angelo S. Mao, Peter Q. Nguyen
  • Publication number: 20200255480
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Application
    Filed: December 13, 2019
    Publication date: August 13, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Publication number: 20200248190
    Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
    Type: Application
    Filed: February 10, 2020
    Publication date: August 6, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Anna M. Duraj-Thatte, Pichet Praveschotinunt
  • Patent number: 10550160
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: February 4, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Publication number: 20190315799
    Abstract: Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers thing films by, for example, disassembly and re-assembly, are disclosed herein.
    Type: Application
    Filed: May 16, 2017
    Publication date: October 17, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne, Anna M. Duraj-Thatte, Peter Q. Nguyen
  • Publication number: 20190201457
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Application
    Filed: August 31, 2017
    Publication date: July 4, 2019
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • Publication number: 20180258435
    Abstract: Embodiments of the present disclosure are directed to methods of genetically modifying bacteria to create amyloid-based materials, such as biofilms created by amyloid fibers, having nonnative functional polypeptides expressed thereon and connected thereto by a linker domain optimized for functioning of the non-native functional polypeptides. According to one aspect, the linker domain is optimized for functioning of a CsgA protein as is it assembled into an amyloid state and for functioning of the functional polypeptide. Exemplary biofilms may include living bacterial cells, non-living bacterial cells or combinations of living bacterial cells and non-living bacterial cells. Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
    Type: Application
    Filed: April 6, 2016
    Publication date: September 13, 2018
    Applicants: President and Fellows of Harvard College, President and Fellows of Harvard College
    Inventors: Neel S. Joshi, Peter Q. Nguyen, Anna Duraj-Thatte, Pichet Praveschotinunt
  • Publication number: 20180186840
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Application
    Filed: November 9, 2017
    Publication date: July 5, 2018
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Patent number: 8236491
    Abstract: A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to a second portion of the thermostable adenylate kinase. Association of the first and second test peptides allows association of the first and second portions of the thermostable adenylate kinase and growth of the thermophilic bacteria at a temperature greater than 70° C.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: August 7, 2012
    Assignee: William Marsh Rice University
    Inventors: Jonathan Silberg, Peter Q. Nguyen
  • Publication number: 20110287462
    Abstract: A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to a second portion of the thermostable adenylate kinase. Association of the first and second test peptides allows association of the first and second portions of the thermostable adenylate kinase and growth of the thermophilic bacteria at a temperature greater than 70° C.
    Type: Application
    Filed: September 23, 2010
    Publication date: November 24, 2011
    Applicant: RICE UNIVERSITY
    Inventors: Jonathan SILBERG, Peter Q. NGUYEN