Patents by Inventor Peter R. Beetham

Peter R. Beetham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200123563
    Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are canola plants, cells, and seeds comprising the mutated genes.
    Type: Application
    Filed: December 27, 2019
    Publication date: April 23, 2020
    Applicant: Cibus US LLC
    Inventors: Christian Schopke, Gregory F. W. Gocal, Keith A. Walker, Peter R. Beetham
  • Patent number: 10612035
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: April 7, 2020
    Assignee: CIBUS US LLC
    Inventors: Greg F. W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Publication number: 20190264219
    Abstract: The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.
    Type: Application
    Filed: May 13, 2019
    Publication date: August 29, 2019
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel Joy SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Publication number: 20190249182
    Abstract: Provided herein include methods and compositions for making targeted changes to a DNA sequence. In various aspects and embodiments, methods and compositions for modifying a DNA sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided. In some aspects and embodiments the modification of DNA involves combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms, such as a DNA cutter.
    Type: Application
    Filed: September 16, 2016
    Publication date: August 15, 2019
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Patent number: 10287594
    Abstract: The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 14, 2019
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. Beetham, Gregory F. W. Gocal, Christian Schopke, Noel Joy Sauer, James Pearce, Rosa E. Segami, Jerry Mozoruk
  • Publication number: 20180355327
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 13, 2018
    Applicant: CIBUS US LLC
    Inventors: PETER R. BEETHAM, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Publication number: 20180327773
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 15, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Publication number: 20180327774
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide. Additionally the present invention relates to mutant E. coli cells that contain mutated EPSPS genes.
    Type: Application
    Filed: July 19, 2018
    Publication date: November 15, 2018
    Applicants: CIBUS US LLC, INCIMA US LLC
    Inventors: Greg F.W. Gocal, Mark E. Knuth, Peter R. Beetham
  • Publication number: 20180320190
    Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
    Type: Application
    Filed: April 30, 2018
    Publication date: November 8, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Patent number: 10100334
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically altered yeast and uses therefore. In some aspects and embodiments, the genetically altered yeast produce isoprenoids, preferably squalene. The genetically altered yeast may have alterations in the expression or activity of enzymes involved in squalene production, for example, acetyl-CoA carboxylase (or “ACCase”), HMG-CoA reductase, squalene epoxidase, and squalene synthase. One or more genes of a genetically altered yeast may be modified by gene repair oligonucleobases. Also are provided methods of producing squalene using a genetically altered yeast. The invention also provides squalene produced by genetically altered yeast.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: October 16, 2018
    Assignee: NUCELIS INC.
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Patent number: 10035991
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: July 31, 2018
    Assignee: CIBUS US LLC
    Inventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Patent number: 9957515
    Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: May 1, 2018
    Assignees: CIBUS US LLC, CIBUS EUROPE, B.V.
    Inventors: Peter R. Beetham, Gregory F. W. Gocal, Christian Schopke, Noel Sauer, James Pearce, Rosa E. Segami, Jerry Mozoruk
  • Publication number: 20180051296
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Application
    Filed: October 16, 2017
    Publication date: February 22, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
  • Patent number: 9796938
    Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: October 24, 2017
    Assignee: NUCELIS INC.
    Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F. W. Gocal
  • Patent number: 9790515
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 17, 2017
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
  • Publication number: 20170145429
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Application
    Filed: January 9, 2017
    Publication date: May 25, 2017
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Publication number: 20170081674
    Abstract: Provided herein include methods and compositions for making targeted changes to a DNA sequence. In various aspects and embodiments, methods and compositions for modifying a DNA sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided. In some aspects and embodiments the modification of DNA involves combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms, such as a DNA cutter.
    Type: Application
    Filed: March 14, 2015
    Publication date: March 23, 2017
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Publication number: 20170051219
    Abstract: Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.
    Type: Application
    Filed: January 28, 2013
    Publication date: February 23, 2017
    Inventors: Mark Knuth, Peter R. Beetham, Keith Walker, Greg F.W. Gocal
  • Publication number: 20170051296
    Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.
    Type: Application
    Filed: March 14, 2016
    Publication date: February 23, 2017
    Inventors: Peter R. BEETHAM, Gregory F.W. GOCAL, Christian SCHOPKE, Noel SAUER, James PEARCE, Rosa E. SEGAMI, Jerry MOZORUK
  • Patent number: 9540662
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: January 10, 2017
    Assignee: NUCELIS LLC
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham