Patents by Inventor Peter R. Byron

Peter R. Byron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190183481
    Abstract: A heart valve anchor has a body that includes a distal portion, a distal end, a proximal portion, and a proximal end. The distal end and the proximal end define a longitudinal axis. The body has an expandable portion that includes a first radially expandable portion at the distal portion of the body, a second radially expandable portion at the proximal portion of the body, and a root portion disposed between the first and second radially expandable portions. The body has a first configuration adapted to be housed at least partially within a tissue penetrating device, and a second configuration in which the first and second radially expandable portions are partially or fully expanded such that the anchor engages tissue in a region between the first and second radially expandable portions.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 20, 2019
    Applicants: BOSTON SCIENTIFIC SCIMED, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: JAMES P. ROHL, MARY M. BYRON, DAVID R. WULFMAN, JAMES K. CAWTHRA, Jr., DEVON N. ARNHOLT, MICHAEL EPPIHIMER, DAVID J. LEHSE, KATHERINE LORRAINE BALDWIN, JOSEPH A. DEARANI, PETER M. POLLAK
  • Publication number: 20090110679
    Abstract: The invention describes methods of pulmonary delivery of a TNF? inhibitor to a subject having a disorder in which TNF? is detrimental, such that the disorder is treated. Also included is a method of achieving systemic circulation of a TNF? inhibitor in a subject comprising administering the TNF? inhibitor to the central lung region or the peripheral lung region of the subject via inhalation, such that systemic circulation of the TNF? inhibitor is achieved.
    Type: Application
    Filed: July 10, 2008
    Publication date: April 30, 2009
    Inventors: Luk-Chiu Li, Yi Shi, Thomas L. Reiland, Masahiro Sakagami, Katherine Nicholson, Peter R. Byron
  • Patent number: 7128067
    Abstract: An aerosol is formed by supplying a material in liquid form to a flow passage and heating the flow passage such that the material volatizes and expands out of an open end of the flow passage. The volatized material combines with ambient air such that volatized material condenses to form the aerosol. An apparatus and method for generating such an aerosol are disclosed wherein the apparatus may include an electrically conductive sleeve at an open end of the flow passage, an electrically conductive flow passage and/or a spacer chamber. The volatilized material may contain a volatilized solute and vehicle such that the resulting aerosol particle sizes of the solute and the vehicle are either different or the same.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: October 31, 2006
    Assignee: Philip Morris USA Inc.
    Inventors: Peter R. Byron, Michael Hindle
  • Patent number: 6883516
    Abstract: A method is provided for generating an aerosol. The method includes preparing a solution formed of a first component in a liquid component such that after volatilization of the liquid component by passing the solution through a flow passage while heating the solution, an aerosol is formed having a predetermined particle size distribution of the first component, wherein the solution is prepared such that the amount of the first component therein is sufficient to achieve the predetermined particle size distribution of the first component. The method also includes passing the solution through the flow passage while heating the solution to a temperature sufficient to volatilize the liquid component, wherein the flow passage comprises an outlet through which the first component and the volatilized liquid component flow, and wherein an aerosol is formed.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: April 26, 2005
    Assignee: Chrysalis Technologies Incorporated
    Inventors: Michael Hindle, Peter R. Byron, Rajiv Gupta
  • Publication number: 20040258622
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 23, 2004
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Patent number: 6713048
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: March 30, 2004
    Assignee: Virginia Commonwealth University
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Patent number: 6701922
    Abstract: An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: March 9, 2004
    Assignee: Chrysalis Technologies Incorporated
    Inventors: Michael Hindle, Peter R. Byron, John N. Hong
  • Publication number: 20040016427
    Abstract: An aerosol is formed by supplying a material in liquid form to a flow passage and heating the flow passage such that the material volatizes and expands out of an open end of the flow passage. The volatized material combines with ambient air such that volatized material condenses to form the aerosol. An apparatus and method for generating such an aerosol are disclosed wherein the apparatus may include an electrically conductive sleeve at an open end of the flow passage, an electrically conductive flow passage and/or a spacer chamber. The volatilized material may contain a volatilized solute and vehicle such that the resulting aerosol particle sizes of the solute and the vehicle are either different or the same.
    Type: Application
    Filed: March 24, 2003
    Publication date: January 29, 2004
    Inventors: Peter R. Byron, Michael Hindle
  • Publication number: 20030136404
    Abstract: An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.
    Type: Application
    Filed: December 20, 2001
    Publication date: July 24, 2003
    Inventors: Michael Hindle, Peter R. Byron, John N. Hong
  • Patent number: 6509005
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which utilize non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy; muscle spasticity; pain; anorexia associated with AIDS wasting syndrome; epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: January 21, 2003
    Assignee: Virginia Commonwealth University
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Publication number: 20020078948
    Abstract: A method is provided for generating an aerosol. The method includes preparing a solution formed of a first component in a liquid component such that after volatilization of the liquid component by passing the solution through a flow passage while heating the solution, an aerosol is formed having a predetermined particle size distribution of the first component, wherein the solution is prepared such that the amount of the first component therein is sufficient to achieve the predetermined particle size distribution of the first component. The method also includes passing the solution through the flow passage while heating the solution to a temperature sufficient to volatilize the liquid component, wherein the flow passage comprises an outlet through which the first component and the volatilized liquid component flow, and wherein an aerosol is formed.
    Type: Application
    Filed: October 19, 2001
    Publication date: June 27, 2002
    Inventors: Michael Hindle, Peter R. Byron, Rajiv Gupta
  • Publication number: 20020031480
    Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy—muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.
    Type: Application
    Filed: September 4, 2001
    Publication date: March 14, 2002
    Inventors: Joanne Peart, Peter R. Byron, Aron H. Lichtman, Billy R. Martin
  • Patent number: 6060069
    Abstract: In a method for treating lung diseases, a drug formulation is prepared by combining micronized crystalline beclomethasone dipropionate and lactose. The drug formulation is placed into a dry powder inhaler which provides inhalable drug particles having a mass median diameter of about 0.5-5.8 microns. The inhaler is preferably largely flow rate independent. Drug and lactose particles are separated in the inhaler during inhalation, most desirably via a spinning element. Due to deep deposition, the drug particles persist in the lungs for a surprisingly long duration, increasing the therapeutic effect of each dose. The patient inhales the drug particles with an inspiratory flow rate of about 10-60 liters/minute, to produce a deep lung deposition of inhaled particles.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: May 9, 2000
    Assignee: Dura Pharmaceuticals, Inc.
    Inventors: Malcolm Hill, Peter R. Byron
  • Patent number: 5492688
    Abstract: Metered dose inhaler (MDI) formulations which utilize 1,1,1,2-tetrafluoroethane (HFC 134a) as the sole propellant are made practical by including a polar surfactant such as polyethylene glycol, diethylene glycol monoethyl ether, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, propoxylated polyethylene glycol, and polyoxyethylene (4) lauryl ether for suspending, solubilizing, wetting and emulsifying the drug constituent and lubricating the valve components of the MDI.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: February 20, 1996
    Assignees: The Center for Innovative Technology, Virginia Commonwealth University
    Inventors: Peter R. Byron, Frank E. Blondino
  • Patent number: 5202110
    Abstract: Beclomethasone diproprionate (BDP) forms a clathrate with HCFC-123, dimethyl ether (DME) and HCFC-141b which are less harmful propellants than the CFC propellants currently used in metered dose inhalers (MDIs). The clathrate can be remicronized and suspended for use in an MDI. BDP also is completely dissolved by DME based propellant blends and certain HCFC 123 propellant blends. Using propellant blends which completely dissolve BDP will assure more efficient dosing with an MDI.
    Type: Grant
    Filed: January 22, 1992
    Date of Patent: April 13, 1993
    Assignee: Virginia Commonwealth University
    Inventors: Richard N. Dalby, Peter R. Byron
  • Patent number: 5190029
    Abstract: Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: March 2, 1993
    Assignee: Virginia Commonwealth University
    Inventors: Peter R. Byron, Richard N. Dalby
  • Patent number: 5182097
    Abstract: Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: January 26, 1993
    Assignee: Virginia Commonwealth University
    Inventors: Peter R. Byron, Richard N. Dalby