Abstract: Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.

Abstract: A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array.

Abstract: An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Abstract: A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.

Abstract: A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Abstract: A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Abstract: A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Abstract: A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Abstract: A timepiece that uses disks having sharp zones of contrast of visual design density to indicate time intervals when the sharp zone of contrast is aligned with time interval indicator markings or traditional time indicator positions on a non-rotatable frame. The disks of the chronograph are continuously graduated in visual design density from an area of greatest density to an area of least density to form a sharp zone or line of contrast. The disks are located so that when the sharp zone or line of contrast is aligned with the time indicator markings or positions on the frame, thus displaying the time in an accurate fashion that is easily and quickly discernable even for individuals that are poor sighted. In addition, the timepiece presents such a strikingly novel design that it makes an aesthetic statement that is desirable for use by individuals with no sight problems.

Abstract: A timepiece that uses disks having sharp zones of contrast of visual design density to indicate time intervals when the sharp zone of contrast is aligned with time interval indicator markings or traditional time indicator positions on a non-rotatable frame. The disks of the chronograph are continuously graduated in visual design density from an area of greatest density to an area of least density to form a sharp zone or line of contrast. The disks are located so that when the sharp zone or line of contrast is aligned with the time indicator markings or positions on the frame, thus displaying the time in an accurate fashion that is easily and quickly discernable even for individuals that are poor sighted. In addition, the timepiece presents such a strikingly novel design that it makes an aesthetic statement that is desirable for use by individuals with no sight problems.

Abstract: A coin validator is provided in the region of its entrance hopper with a flap which is caused to pivot against the action of a spring when a coin is inserted in the hopper. In the case of fraudulent use of the coin validator wherein a thread is attached to a coin, the movement of the flap into the closed position following passage of the coin causes a tension to be applied in the trailing thread, and the thread under tension is then sensed by a lever mechanism. Actuation of the lever mechanism by the tensioned thread inhibits validation of the attached coin, e.g. by causing any credit added by the passage of the coin past a testing station to be debited before returning the coin to the user.

Abstract: In a master cylinder (20), a cap (30) for guiding a primary piston (50) is located within an end opening (24) of a body (22) of the master cylinder (20). The end cap (30) retains a sleeve (40) and other components within a bore (12) of the master cylinder (20), and is attached to the body (22) of the master cylinder (20) by way of a biasing retention mechanism (45; 145, 150; 260). The mechanism (45; 145, 150; 260) may bias the end cap (30) axially inwardly of the bore (12), bias a gripping ring member (145) radially outwardly into engagement with the body (22) of the master cylinder (20), and retain a first end (32) of the end cap (30) within the bore (12) in accordance with the extent to which the first end (32) is inserted axially into the bore (12).

Abstract: A coin testing apparatus subjects a coin inserted into a coin entry (1) and rolling down an inclined track (2) to testing at a testing station (3) comprising sensors (4,5,6) which may for example be inductive sensors. If a coin is found to be acceptable an accept signal is generated and this causes gate mechanism (8) to open to permit the coin to access accept path (9), the gate mechanism (8) being normally closed so that unacceptable coins can only access a reject path (10). A post-gate detector (11) in the accept path (9) senses the passage of an accepted coin and serves to close the gate mechanism (8) and also to determine allocation of a customer credit. A pre-gate detector (12) upstream of the gate mechanism (8) has its output logically processed with the accept signal produced when an acceptable coin is tested and/or with the output of the post-gate detector (11).