Patents by Inventor Peter R. Maroko

Peter R. Maroko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and method of treatment for improving circulatory performance
    Patent number: 5153178
    Abstract: Compositions and methods for increasing the contractility of the mammalian heart as shown by a positive inotropic effect are disclosed, employing protoberberine alkaloids such as berberine, discretine, xylopinine, berrberubine, tetrahydropalmatine, and stepharotine in combination with cardiac glycosides such as ouabain, digoxin, digitoxin, deslanoside and digitalis.
    Type: Grant
    Filed: August 1, 1988
    Date of Patent: October 6, 1992
    Inventor: Peter R. Maroko
  • Compositions for improving circulatory performance
    Patent number: 4980344
    Abstract: Compositions having a compound from the family of protoberberines, especially coreximine, are used in conjunction with a cardiac glycoside. The composition and therapeutic method of administering the composition, orally and otherwise, increases the contractility of the heart as shown by a positive inotropic effect. The positive inotropic effect is observed over a wide therapeutic index.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: December 25, 1990
    Inventor: Peter R. Maroko
  • Compounds, compositions and method of treatments for improving circulatory performance
    Patent number: 4761417
    Abstract: A method of increasing the contractility of the mammalian heart as shown by a positive inotropic affect is disclosed, employing protoberberine alkaloids such as berberrubine or tetrahydropalmitane, alone or in combination with cardiac glycosides such as ouabain, digoxin, digitoxin or delanoside.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: August 2, 1988
    Inventor: Peter R. Maroko
  • Composition for improving circulatory performance
    Patent number: 4749708
    Abstract: A method of increasing the contractility of the mammalian heart as shown by a positive inotropic effect employing coreximine compounds is disclosed.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: June 7, 1988
    Inventor: Peter R. Maroko
  • Method and composition for the treatment of cardiac arrhythmias
    Patent number: 4556664
    Abstract: A method and pharmaceutical composition are disclosed for treating cardiac arrhythmias employing as an active ingredient at least one compound selected from piperidine-2-carboxylic acid-2,6-dimethyl anilide; piperidine-2-carboxylic acid-2,4-dimethyl anilide; piperidine-2-carboxylic acid-2,4,6-trimethyl anilide; and piperidine-2-carboxylic acid-2-methyl-5-chloro anilide.
    Type: Grant
    Filed: March 13, 1984
    Date of Patent: December 3, 1985
    Assignee: Gunnar A. K. Aberg
    Inventors: Gunnar A. K. Aberg, Peter R. Maroko, Bo T. af Ekenstam
  • Method of treatment patients at risk of sudden death
    Patent number: 4430338
    Abstract: The present invention therefore provides a method of treatment patients at risk of so-called sudden death caused by fatal atherothrombosclerotic conditions and which treatment is intended to promote survival, characterized by a chronic administration to the patient of a compound of the general formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, in which R represents a straight or branched alkyl group of 1-4 (incl.) carbon atoms,Ar, Ar' represent both an aromatic group, andA is a tertiary amino group selected from di-alkylamino and a nitrogen containing 5- or 6-membered ring,in an effective dialy dosage.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: February 7, 1984
    Assignee: Akzo N.V.
    Inventors: Frans H. J. Jansen, Peter R. Maroko