Patents by Inventor Peter R. Rhode
Peter R. Rhode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7141656Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: May 3, 2001Date of Patent: November 28, 2006Assignee: Altor Bioscience CorporationInventors: Peter R. Rhode, Jin-An Jiao, Martin Burkhardt, Hing C. Wong
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Patent number: 7074904Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.Type: GrantFiled: July 6, 2001Date of Patent: July 11, 2006Assignee: Altor Bioscience CorporationInventors: Hing C. Wong, Peter R. Rhode, Jon A. Weidanz, Susan Grammer, Ana C. Edwards, Pierre-Andre Chavaillaz, Jin-An Jiao
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Patent number: 7074905Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II ?2 chain modification, e.g., deletion of essentially the entire class II ?2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: January 19, 2001Date of Patent: July 11, 2006Assignee: Altor BioScience CorporationInventors: Peter R. Rhode, Jorge Acevedo, Martin Burkhardt, Jin-an Jiao, Hing C. Wong
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Publication number: 20040253632Abstract: Disclosed are methods for identifying compounds that modulate an immune complex that includes a T cell receptor (TCR) and a major histocompatibility complex (MHC) antigen. The invention has many useful applications including providing high throughput screening assays for detecting compositions that can modulate an immune response.Type: ApplicationFiled: May 16, 2001Publication date: December 16, 2004Applicant: Sunol Molecular CorporationInventors: Peter R. Rhode, Vaughan Wittman, Jon A. Weidanz, Martin Burkhardt, Kimberlyn F. Card, Rony Tal, Jorge Acevedo, Hing C. Wong
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Publication number: 20020198144Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.Type: ApplicationFiled: July 6, 2001Publication date: December 26, 2002Applicant: Dade International, Inc.Inventors: Hing C. Wong, Peter R. Rhode, Jon A. Weidanz, Susan Grammer, Ana C. Edwards, Pierre-Andre Chavaillaz, Jin-An J.J. Jiao
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Publication number: 20020091079Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II &bgr;2 chain modification, e.g., deletion of essentially the entire class II &bgr;2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: ApplicationFiled: January 19, 2001Publication date: July 11, 2002Applicant: Sunol Molecular CorporationInventors: Peter R. Rhode, Jorge Acevedo, Martin Burkhardt, Jin-an Jiao, Hing C. Wong
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Publication number: 20020034513Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: ApplicationFiled: May 3, 2001Publication date: March 21, 2002Applicant: Sunol Molecular CorporationInventors: Peter R. Rhode, Jin-An Jiao, Martin Burkhardt, Hing C. Wong
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Patent number: 6309645Abstract: The present invention relates to novel complexes of major histocomability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: April 28, 1998Date of Patent: October 30, 2001Assignee: Sunol Molecular CorporationInventors: Peter R. Rhode, Jin-An Jiao, Martin Burkhardt, Hing C. Wong
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Patent number: 6306605Abstract: Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.Type: GrantFiled: February 1, 2000Date of Patent: October 23, 2001Assignee: Sunol Molecular CorporationInventors: Jorge L. Acevedo, Peter R. Rhode
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Patent number: 6232445Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II &bgr;2 chain modification, e.g., deletion of essentially the entire class II &bgr;2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: October 29, 1997Date of Patent: May 15, 2001Assignee: Sunol Molecular CorporationInventors: Peter R. Rhode, Jorge Acevedo, Martin Burkhardt, Jin-an Jiao, Hing C. Wong
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Patent number: 6156514Abstract: Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.Type: GrantFiled: December 3, 1998Date of Patent: December 5, 2000Assignee: Sunol Molecular CorporationInventors: Jorge L. Acevedo, Peter R. Rhode
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Patent number: 5869270Abstract: The present invention relates to novel complexes of major histocompatibility complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: January 31, 1996Date of Patent: February 9, 1999Assignee: Sunol Molecular CorporationInventors: Peter R. Rhode, Jin-An Jiao, Martin Burkhardt, Hing C. Wong
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Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
Patent number: 5516637Abstract: The present invention relates to a fusion protein, comprising a pilin protein or a portion thereof and a heterologous polypeptide (target protein). In a preferred embodiment it relates to a method for displaying the target protein on the outer surface of a bacterial host cell capable of forming pilus. In certain embodiments, it is desirable that the pilus is a receptor for bacteriophage attachment and infection. The F pilus is preferred.Type: GrantFiled: June 10, 1994Date of Patent: May 14, 1996Assignee: Dade International Inc.Inventors: Grace P. Huang, Peter R. Rhode, Jeffrey R. Stinson, Hing C. Wong