Patents by Inventor Peter R. Roller

Peter R. Roller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof
    Patent number: 5688992
    Abstract: The present invention relates to non-phosphorus containing O-malonyltryrosyl compounds, derivatives thereof, uses of the O-malonyltryrosyl compounds in the synthesis of peptides, and O-malonyltryrosyl compound-containing peptides. The O-malonyltyrosyl malonyltyrosyl compounds and O-malonyltryrosyl compound-containing peptides of the present invention are uniquely stable to phosphotases, capable of crossing cell membranes, suitable for application to peptide synthesis of O-malonyltryrosyl compound-containing peptides, and amenable to prodrag defivatization for delivery into cells. The present invention also provides for O-malonyltryrosyl compound-containing peptides which exhibit inhibitory potency against binding interactions of receptor domains with phosphotyrosyl-containing peptide ligands.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: November 18, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Terrence R. Burke, Jr., Bin Ye, Miki Akamatsu, Hemanta K. Kole, Xinjian Yan, Peter R. Roller