Patents by Inventor Peter RAHFELD

Peter RAHFELD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENZYMATIC COMPOSITIONS FOR CARBOHYDRATE ANTIGEN CLEAVAGE ON DONOR ORGANS, METHODS AND USES ASSOCIATED THEREWITH
    Publication number: 20240294895
    Abstract: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods. uses. associated therewith. In particular, the perfusion fluids comprise two enzymes. GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore. the compositions described herein were found to have activity at temperatures and ph levels suitable for cell viability.
    Type: Application
    Filed: February 14, 2024
    Publication date: September 5, 2024
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, UNIVERSITY HEALTH NETWORK
    Inventors: Marcelo CYPEL, Aizhou WANG, Shafique KESHAVJEE, Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU
  • ENZYMATIC COMPOSITIONS FOR CARBOHYDRATE ANTIGEN CLEAVAGE ON DONOR ORGANS, METHODS AND USES ASSOCIATED THEREWITH
    Publication number: 20210345601
    Abstract: Provided herein are perfusion fluids for enzymatically cleaving A-antigens from a donor organ, and methods, uses, associated therewith. In particular, the perfusion fluids comprise two enzymes, GalNAcDeacetylase and Galactosaminidase and the fluids may further comprise a buffered extracellular solution and/or a crowing agent. Furthermore, the compositions described herein were found to have activity at temperatures and pH levels suitable for cell viability.
    Type: Application
    Filed: August 16, 2019
    Publication date: November 11, 2021
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, UNIVERSITY HEALTH NETWORK
    Inventors: Marcelo CYPEL, Aizhou WANG, Shafique KESHAVJEE, Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU
  • ENZYMATIC COMPOSITIONS FOR CARBOHYDRATE ANTIGEN CLEAVAGE, METHODS, USES, APPARATUSES AND SYSTEMS ASSOCIATED THEREWITH
    Publication number: 20210324361
    Abstract: Provided herein are enzymatic compositions for carbohydrate antigen cleavage, methods, uses, apparatuses and systems associated therewith. In particular, the composition comprises two enzymes, GalNAcDeacetylase and Galactosaminidase and the composition may further comprise a crowding agent. Furthermore, the compositions described herein were found to have activity a temperatures and pH levels suitable for cell viability.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 21, 2021
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Stephen G. WITHERS, Peter RAHFELD, Jayachandran KIZHAKKEDATHU