Patents by Inventor Peter Ratcliffe

Peter Ratcliffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080028650
    Abstract: A way for a consumer to display personalized information is provided as a display device for displaying the personalized information or other objects, and an attachment mechanism that attaches the display device to a vehicle by way of a base and that is also detachable from the base. The personalized information may be placed on or inside the display device for the consumer, or the consumer may place the personalized information on or inside the display device himself. The personalized information may represent military affiliation, authorization, or may be any other personalized image or text. The base may be affixed to the vehicle by way of a magnet or other mechanism. The display device may include a recess for holding a can or cup. The display device may be pivoted relative to the base so that the display device may be displayed perpendicular or parallel to a plane defined by the vehicle's wheels.
    Type: Application
    Filed: May 17, 2007
    Publication date: February 7, 2008
    Applicant: HoodEz LLC
    Inventor: Peter Ratcliffe
  • Publication number: 20070185045
    Abstract: The present invention provides methods for increasing endogenous globin expression in a subject, specifically ?-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., ? thalassemia and sickle cell disease.
    Type: Application
    Filed: February 6, 2006
    Publication date: August 9, 2007
    Inventor: Peter Ratcliffe
  • Publication number: 20070124972
    Abstract: A method of advertising involves providing one or more advertisements that attach to a vehicle with an attachment mechanism, by way of a base. Each advertisement can be easily detached from the base for the purposes of attaching another advertisement without removing the base from the vehicle. An attractive cap using an identical attachment mechanism can be provided to cover the base. The base, the advertisement, and the cap can be provided as a set. Advertisement designs can be quickly and conveniently swapped at the vehicle user's discretion because they all utilize a common base design. Advertisers may provide the user with an advertisement for the advertiser's product, and with a plate compatible with the base already on the user's vehicle. The present invention provides a novel way for individuals to advertise their likings and a novel way for organizations to reach consumer attention by creating roaming advertisements for new and established brands and markets.
    Type: Application
    Filed: March 30, 2006
    Publication date: June 7, 2007
    Inventor: Peter Ratcliffe
  • Publication number: 20070066576
    Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.
    Type: Application
    Filed: September 11, 2006
    Publication date: March 22, 2007
    Applicant: Isis Innovation Limited
    Inventors: Christpoher Schofield, Patrick Maxwell, Christopher Pugh, Peter Ratcliffe
  • Publication number: 20070048728
    Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.
    Type: Application
    Filed: October 16, 2003
    Publication date: March 1, 2007
    Inventors: Peter Ratcliffe, Christopher Pugh, Christopher Schofield, Kirsty Hewitson
  • Publication number: 20070042937
    Abstract: The present invention provides methods for increasing endogenous globin expression in a subject, specifically ?-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., ? thalassemia and sickle cell disease.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 22, 2007
    Applicants: FibroGen, Inc., Isis Innovation Limited
    Inventors: Stephen Klaus, Peter Ratcliffe
  • Publication number: 20060188981
    Abstract: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked by organic or inorganic molecules, preferably organic molecules, more preferably proteins/polypeptides that specifically bind to that site. Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Vectors are provided that encode the variable domains of MN-specific antibodies and a flexible linker polypeptide separating those domains. Further vectors are disclosed that encode a cytotoxic protein/polypeptide operatively linked to the MN gene promoter or a MN gene promoter fragment comprising the HIF-1 consensus binding sequence, and which vectors preferably further encode a cytokine.
    Type: Application
    Filed: February 17, 2006
    Publication date: August 24, 2006
    Inventors: Adrian Harris, Peter Ratcliffe
  • Publication number: 20060084123
    Abstract: The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect, the invention provides diagnostic/prognostic tools for determining the presence of hypoxia in a tissue in a vertebrate, preferably a human, and for measuring the relative degree of hypoxia in said vertebrate. In another aspect, the invention provides methods using tumor biopsies to predict the radioresistance of a preneoplastic/neoplastic tissue in a vertebrate subject, preferably a human patient, for diseases in which MN/CA IX levels can be used to indicate radiobiologically relevant tumor hypoxia. Such predictive methods can be used as an aid in patient therapy selection.
    Type: Application
    Filed: June 24, 2005
    Publication date: April 20, 2006
    Inventors: Adrian Harris, Peter Ratcliffe, Dirk Vordermark
  • Publication number: 20050244915
    Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.
    Type: Application
    Filed: May 23, 2003
    Publication date: November 3, 2005
    Inventors: Christopher Pugh, Jonathan Gleadle, Peter Ratcliffe, Christopher Schofield, Luke McNeill
  • Publication number: 20050227948
    Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.
    Type: Application
    Filed: March 21, 2003
    Publication date: October 13, 2005
    Inventors: Christopher Schofield, Patrick Maxwell, Christopher Pugh, Peter Ratcliffe
  • Publication number: 20050003452
    Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.
    Type: Application
    Filed: July 29, 2004
    Publication date: January 6, 2005
    Applicant: Isis Innovation Limited
    Inventors: Peter Ratcliffe, Patrick Maxwell, Christopher Pugh
  • Patent number: D582327
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: December 9, 2008
    Inventor: Peter Ratcliffe