Patents by Inventor Peter Rhode

Peter Rhode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 12371472
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: October 31, 2023
    Date of Patent: July 29, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • METHOD OF TREATING PANCREATIC CANCER
    Publication number: 20250195614
    Abstract: Provided herein are methods of treating unresectable advanced/metastatic pancreatic cancer in a subject.
    Type: Application
    Filed: March 2, 2023
    Publication date: June 19, 2025
    Inventors: Hing C. WONG, Peter RHODE
  • Human immunodeficiency virus-specific T cell receptors
    Patent number: 12325734
    Abstract: Engineered TCR molecules specific to retroviral peptide/HLA complexes guide direct killing and/or enable robust immune responses against HIV infected cells. In a first aspect, a TCR fusion polypeptide comprises a TCR variable alpha (V?) domain, a TCR variable beta domain (V?) and a TCR constant region domain (C), wherein the TCR fusion polypeptide is specific for HIV peptides.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: June 10, 2025
    Assignees: Altor Bioscience LLC, The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Peter Rhode, Mark Connors, Stephen Migueles
  • COMBINATION THERAPIES FOR MULTIPLE MYELOMA
    Publication number: 20250161412
    Abstract: Compositions and methods are provided to treat and prevent cancers, such as myelomas, and include adoptive cell therapies in combination with an IL-15 superagonist and one or more chemotherapeutic agents.
    Type: Application
    Filed: January 15, 2025
    Publication date: May 22, 2025
    Inventors: John Lee, Peter Rhode
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20250152686
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: January 15, 2025
    Publication date: May 15, 2025
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF ADVANCED SOLID TUMORS
    Publication number: 20250134974
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of an unresectable, advanced, recurrent, and/or metastatic solid tumor or an unresectable, advanced, recurrent, and/or metastatic solid cancer.
    Type: Application
    Filed: October 30, 2024
    Publication date: May 1, 2025
    Inventors: Hing C. Wong, Peter Rhode
  • IL-15-based molecules with anti-CD20 antibody and methods of use
    Patent number: 12268732
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 7, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Compositions comprising IL-15N72D-based molecules and bacillus calmette-guerin (BCG)
    Patent number: 12268731
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: April 18, 2024
    Date of Patent: April 8, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20250066442
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: October 31, 2024
    Publication date: February 27, 2025
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 12233116
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 25, 2024
    Date of Patent: February 25, 2025
    Assignee: Altor Bioscience, LLC.
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20250018020
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 16, 2025
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based molecules and methods of treating a neoplasia
    Patent number: 12186372
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: January 7, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 12168680
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: December 17, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • Methods of treating a neoplasia with IL-15-based molecules and CTLA-4 antibody
    Patent number: 12097244
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 22, 2023
    Date of Patent: September 24, 2024
    Assignee: Altor BioScience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240307494
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 7, 2024
    Publication date: September 19, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240307495
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 7, 2024
    Publication date: September 19, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • METHOD FOR STIMULATING TUMOR-INFILTRATING LYMPHOCYTES WITH AN IL-15:IL-15R COMPLEX
    Publication number: 20240299498
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: May 30, 2024
    Publication date: September 12, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240261373
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 18, 2024
    Publication date: August 8, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • COMPOSITIONS COMPRISING IL-15N72D-BASED MOLECULES AND BACILLUS CALMETTE-GUERIN (BCG)
    Publication number: 20240252591
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 18, 2024
    Publication date: August 1, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20240252609
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: March 20, 2024
    Publication date: August 1, 2024
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong