Abstract: Disclosed herein are methods for inducing immunity against a virus such as a coronavirus in the mucosal tissue of a patient, include administering a vaccine composition to the patient by oral administration (e.g., nasal injection, nasal inhalation, oral inhalation, and/or oral ingestion). Also disclosed are compositions for assaying the presence of anti-viral antibodies induced by the administered vaccine or the presence of viral proteins in a saliva sample include a stabilizing solution and may also include the use of aragonite particle beads. Compositions and methods are presented for prevention and/or treatment of a coronavirus disease wherein the composition comprises comprises a recombinant entity. The recombinant entity is bivalent, comprising a nucleic acid encoding a coronavirus 2 nucleocapsid protein CoV2 nucleocapsid protein fused to an endosomal targeting sequence, and a nucleic acid encoding a CoV2 spike protein sequence optimized for cell surface expression.

Abstract: A system for negotiating a purchase of a pharmaceutical treatment between a provider of the pharmaceutical treatment and a plurality of purchasers of the pharmaceutical treatment. The method receives one or more assumptions associated with a patient. An input field in a graphical user interface of a first computing device is displayed where the first computing device received an offer to purchase the pharmaceutical treatment from the purchaser. The offer to purchase is received from the first computing device via a network. The offer to purchase is modified. The modified offer to purchase is displayed on a second computing device that is associated with a provider of the pharmaceutical treatment via a graphical user interface on the second computing device. An input field in the graphical user interface of the second computing device that is configured to receive, from the provider, an offer to provide the pharmaceutical treatment is displayed.

Abstract: A system for customizing user parameters relating to a pharmaceutical treatment, receives, a first set of parameters associated with the pharmaceutical treatment, that indicate factors associated with the pharmaceutical treatment, in a first format. The system determines a subset of the set of first parameters based on the one or more factors and converts them into a second format. The system provides the second set of parameters to a second computing device, receives from the second computing device, a third set of parameters, wherein the third set of parameters are based on the one or more factors, the third set of parameters being provided in a third format, converts the third set of parameters from the second third format to the first format based on a second set of parameters, and present the converted third set of parameters received from the second computing device to the first computing device party.

Abstract: In some aspects, the disclosure relates to compositions of peptide mimics useful in the treatment of Neisseria gonorrhoeae (N. gonorrhoeae). In some embodiments, the peptide mimics are multi-antigenic molecules of a conserved gonococcal lipoohgosaccharaide (LOS) epitope. In some aspects, the disclosure relates to methods of making peptide mimics for the treatment of N. gonorrhoeae. In some aspects, the disclosure relates to methods of using peptide mimics for the treatment of N. gonorrhoeae.

Abstract: Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.

Abstract: A system for customizing user parameters relating to a pharmaceutical treatment, receives, a first set of parameters associated with the pharmaceutical treatment, that indicate factors associated with the pharmaceutical treatment, in a first format. The system determines a subset of the set of first parameters based on the one or more factors and converts them into a second format. The system provides the second set of parameters to a second computing device, receives from the second computing device, a third set of parameters, wherein the third set of parameters are based on the one or more factors, the third set of parameters being provided in a third format, converts the third set of parameters from the second third format to the first format based on a second set of parameters, and present the converted third set of parameters received from the second computing device to the first computing device party.

Abstract: A method for preparing a radiolabeled pharmaceutical. The method comprises passing a mixture that includes a radiolabeled compound through a column that contains an ion exchange resin to retain the radiolabeled compound on the ion exchange resin. At least a portion of the mixture passes through the column without being retained on the ion exchange resin. The method further comprises eluting the radiolabeled compound off the ion exchange resin using an eluting solution (e.g., a sodium chloride solution) to form a radiolabeled pharmaceutical.

Abstract: An article carrier, removably mountable on an upright luggage carrying frame of a bicycle, comprises a rigid sheath having closed top and an open bottom receiving the rigid frame. The rigid sheath fits into a downwardly open pocket of a flexible article-carrying bag. A rigid panel for supporting the bag is hinged to the sheath adjacent the bottom opening, and can be rotated downward from a condition in which it is parallel to a front wall of the sheath to a horizontal condition, and is prevented by a stop from being rotated beyond the horizontal condition. The downwardly open pocket can be on the exterior of the bag or on the interior.

Abstract: The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against Neisseria meningitidis. The invention also provides kits for carrying out these screens, and improved vaccines against Neisseria meningitidis.

Abstract: An article carrier, removably mountable on an upright luggage carrying frame of a bicycle, comprises a rigid sheath having closed top and an open bottom receiving the rigid frame. The rigid sheath fits into a downwardly open pocket of a flexible article-carrying bag. A rigid panel for supporting the bag is hinged to the sheath adjacent the bottom opening, and can be rotated downward from a condition in which it is parallel to a front wall of the sheath to a horizontal condition, and is prevented by a stop from being rotated beyond the horizontal condition. The downwardly open pocket can be on the exterior of the bag or on the interior.

Abstract: A position sensor system for use in sensing the position of a component located within a housing and disposed, at least in part, within a fluid, the system comprising a first acoustic position sensor operable to transmit a first acoustic signal through the fluid and to sense a reflection of the first acoustic signal from a first surface to derive a first position signal, a second acoustic position sensor operable to transmit a second acoustic signal through the fluid and to sense a reflection of the second acoustic signal from a second surface to derive a second position signal, and means operable, using the first and second position signals, to derive a position signal indicative of the position of the component within the housing.

Abstract: Deposition of a thin film is monitored by illuminating the thin film with an incident beam during deposition of the thin film, wherein at least a portion of the incident beam reflects off the thin film to yield a reflected beam; measuring intensity of the reflected beam from the thin film during growth of the thin film to obtain reflectance; and curve-fitting at least part of an oscillation represented by the reflectance data to obtain information about at least one of thickness, growth rate, composition, and doping of the thin film.

Abstract: A signal processing circuit comprising a chopper amplifier in combination with a circuit or device having an acquisition period, and wherein a clock controlling the chopper amplifier is controlled such that a predetermined or known number of clock transitions occur during the acquisition period.

Abstract: The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against Neisseria meningitidis. The invention also provides kits for carrying out these screens, and improved vaccines against Neisseria meningitidis.

Abstract: The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae, which epitope is not found on human blood group antigens. This invention also relates to methods and compositions using such peptide mimics for the prophylaxis of gonorrheal infections.

Abstract: A development toolkit can create a message data payload for use on a communications network having rules for data representation. The development toolkit includes an editor configured to create a first portion of a message data payload having usable data for transmission over the communications network, and to create a second portion of the message data payload having information to describe the usable data. The editor includes constraints that limit the manner in which creating the first and second portions and the association occurs. The constraints are defined in part by the rules for data representation. The toolkit also includes a user interface to display a visualization of the message data payload from the editor. With this configuration, a user can conveniently create a message data payload for immediate use and see a graphical representation of the message data payload as it is created.

Abstract: The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae, which epitope is not found on human blood group antigens. This invention also relates to methods and compositions using such peptide mimics for the prophylaxis of gonorrheal infections.

Abstract: The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae, which epitope is not found on human blood group antigens. This invention also relates to methods and compositions using such peptide mimics for the prophylaxis of gonorrheal infections.

Abstract: The resistivity of a p-doped III-V or a p-doped II-VI semiconductor material is reduced. The reduction of resistivity of the p-type III-V or a II-VI semiconductor material is achieved by applying an electric field to the semiconductor material. III-V nitride-based light emitting diodes are prepared.

Abstract: The resistivity of a p-doped III-V or a p-doped II-VI semiconductor material is reduced. The reduction of resistivity of the p-type III-V or a II-VI semiconductor material is achieved by applying an electric field to the semiconductor material. III-V nitride-based light emitting diodes are prepared.