Abstract: Compounds of the class of adenosines, represented by structural formula I, wherein R is C1-4 alkoxy, and X is H or OH, excluding 2-methoxyadenosine, are useful as analgesics, particularly in a method of preventing, treating, or ameliorating pain which comprises administering a compound of formula I to a subject in need of such prevention, treatment, or amelioration.

Abstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.

Abstract: A method of refining molten metal in a vessel by the reaction of oxygen with impurities in the molten metal comprises the steps of: a) ejecting at least one primary jet of oxygen from a lance positioned above the molten metal into the molten metal to react with impurities therein and to form a layer of molten slag; b) continuing to eject the primary jet of oxygen from the lance and thereby causing the primary bet of oxygen to pass through the slag layer into the molten metal; c) ejecting a plurality of secondary jets of oxygen from the lance, the secondary jet of oxygen travelling for a distance separately from the primary jet of oxygen; and d) entraining the secondary jets of oxygen into the primary jet of oxygen upstream of the entry of the primary jet of oxygen into the molten metal.

Abstract: A system and method are provided for vendor management during a procurement process. Vendor qualification data is stored and compared relative to a procurement request. Based upon statistical data in relation to previous bidding information and vendor relevance a list of recommended Vendors for invitation can be generated. The recommended list ensures fairness in the selection of Vendors and statistics are automatically updated. Data in relation to the selection process is maintained to provide an audit trail through the procurement process.

Abstract: To avoid potentially erroneous results, monitoring the operation of an oxygen sensor of an internal combustion engine of a motor vehicle to detect a slow response of the oxygen sensor as indicative of an oxygen sensor fault is temporarily suspended in response to a brake operation transition of a braking system of the vehicle.

Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.

Abstract: A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.

Abstract: A method of controlling total jet pressure from the head of a metallurgical lance for introducing gas into a volume of metal in a vessel. The lance head has at least one ejector, which has a nozzle located in a bore of the lance head and has an annular gas passage between at least one nozzle and the wall of the bore. The method proceeds by adjusting the annular gas velocity from a first Mach number to a second mach number to effect change of the total jet pressure.

Abstract: A metallurgical lance for introducing gas into a volume of molten material in a furnace includes a head having a bore extending therethrough, a mounting assembly at the head in the bore, and a nozzle detachably secured to the mounting assembly by a connection, the nozzle adapted to coact with a tool releasably engagable with the nozzle to insert and withdraw same from the lance head through the bore without dismantling the nozzle.

Abstract: Various ocular fixation devices are disclosed. One ocular fixation device includes first and second rings, where at least one of the rings includes means for fixating ocular tissue of an eye. The means for fixating are arranged to grasp the ocular tissue of the eye and to release the ocular tissue of the eye based on rotation of at least one of the first and second rings. The ocular fixation device may also include one or more structures on which a surgical tool can be mounted on the ocular fixation device at one or more locations. For instance, a dome of the ocular fixation device could include one or more holes that are configured to receive one or more projections from the surgical tool. As another example, a base of the ocular fixation device could include one or more notches configured to receive a projection from the surgical tool.

Abstract: One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

Abstract: Use of compounds of the following formula as analgesics, in particular antihyperalgesics, is described: wherein R is C1-4 alkoxy, and X is H or OH.

Abstract: Methods for identifying potential therapeutic agents involve determining the affinity and/or efficacy of a test compound for an adensoine receptor at a relatively high pH and at a relatively low pH. Compounds with greater affinity and/or efficacy at the low pH are identified as potential therapeutic agents, in particular for the treatment of pain or inflammation.

Abstract: Use of spongosine (2-methoxyadenosine) as an analgesic, in particular for the treatment of hyperalgesia, is described.

Abstract: Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.

Abstract: Use of compounds of formula: (I) wherein R is C1-4 alkoxy and X is H or OH; for the prevention, treatment, or amelioration of cancer, inflammation, auto-immune disease, ischemia-reperfusion injury, epilepsy, sepsis, septic shock, neurode-generation (including Alzheimer's Disease), muscle fatigue or muscle cramp is described. The compounds are effective at very low doses, and so can be administered at doses at which serious side effects are not observed.

Abstract: A time delay beamformer comprises input channels, which have associated samplers arranged to sample inputs signal carried upon the input channels. The samplers sample the input channels at a number of points in time to produce a number of sampled signals. An adaptive processor receives each of the input signals and each of the sampled signals, and generates processed signals therefrom. Time delay devices introduce a steering time delay to the processed signals and a summer generates a beamformed output signal the delayed processed signals.

Abstract: Surgical instruments and methods are provided. In one aspect, a method of securing a fixation device within an opening in a tissue is provided, including delivering a material in a flowable state to said opening, and changing the state of the material so that the material forms an interference fit that secures the fixation device in the opening.

Abstract: The present invention provides a new and unique method of controlling web page navigation by a user. The method of the present invention easily modifies the web page (56) without altering the underlying HTML code of the page (56). The JavaScript program controls the overall navigation experience according to a pre-programmed set of Actions (111) and user interface elements. The authoring component (60) of the invention enables creation of the JavaScript assist program according to the desired help or demonstration features. Most importantly, each of the web objects (100) that are linked to a particular event (111) and action are uniquely and specifically identified so that a given event or action will be executed upon interaction with a web object (100) regardless of where that web object (100) appears on the web page (56) or web site. Thus, the control of navigation of web objects (100) survives across web pages (56) even if those underlying web pages (56) are modified.

Abstract: The present invention is directed to a gas sampling system for conducting respiratory gases from a patient respiratory gas output mechanism to a respiratory gas monitoring device. A gas sampling tube is coupled to an input connector. The gas sampling tube is configured to conduct the respiratory gases from the patient to the gas monitoring device. An output connector couples the gas sampling tube to the monitor input connector. An output dryer tube is coupled between the gas sampling tube and the output connector. The output dryer tube is characterized by a tube length and a relative moisture removal efficiency. The relative moisture removal efficiency is dependent on the tube length. The tube length is selected to limit the moisture content of the respiratory gasses being directed into the respiratory gas monitor to a predetermined level.