Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: A system and method for alerting analysts to the presence of risk indicative information in a source report such as an SEC Edgar filing are described. An alert containing the risk indicative text may be e-mailed to an analyst and a link may be provided so that the analyst may easily access and view the complete report and additional identified risk indicative information. Additionally, the alerts and reports may be organized according to a hierarchical taxonomy of risk and/or corporate categories.