Abstract: The present invention is directed to novel methods of treating and reducing perimenopausal and climacteric symptoms using compositions comprising proanthocyanidins. In one embodiment, the methods provide for perimenopausal and climacteric symptom reduction without the use of female hormones or hormone like substances.

Abstract: Methods and compositions for inhibition of both COX-1 and COX-2 are provided by this disclosure. The methods and compositions on the invention are effective for providing relief from pain.

Abstract: The invention relates to methods for treating osteoarthritis by administering a composition consisting essentially of proanthocyanidins to a patient suffering from such a disorder.

Abstract: The invention is directed to a method for treating ulcers, including ulcers of the lower leg, by topical plus oral administration of proanthocyanidins to a patient.

Abstract: Methods and compositions, including, foods and beverages, for treating, preventing or ameliorating Helicobacter pylori-associated disorders, particularly disorders of the gastrointestinal tract such as peptic ulcers of the stomach are provided by this disclosure. In one preferred aspect, the method comprises administering to a Helicobacter pylori infected subject a therapeutically effective amount of a composition comprising Type-B procyanidins, Type-C procyanidins, or a mixture thereof.

Abstract: Sexual wellness or sexual fitness is enhanced over time by administrating on a daily basis a source of proanthocyanidins and a source of arginine. Both sources may be blended into a composition or taken separately from a kit. The source of arginine may be a salt or peptide of L-arginine and aspartic acid such as arginine aspartate. The proanthocyanidins stimulate an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substration that is the source of the arginine. A sufficient amount of the nitric oxide is released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the combination may contain as a further ingredient a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer.

Abstract: This invention relates to air filter components and apparatuses that act to scavenge gas phase free radicals present in polluted air. In specific aspects, the invention relates to filters that contain proanthocyanidins for scavenging the free radicals. The present invention is also directed to a method for producing air filter components and apparatuses with scavenging effects on gas phase free radicals.

Abstract: This invention relates to air filter components and apparatuses that act to scavenge gas phase free radicals present in polluted air. In specific aspects, the invention relates to filters that contain proanthocyanidins for scavenging the free radicals. The present invention is also directed to a method for producing air filter components and apparatuses with scavenging effects on gas phase free radicals.

Abstract: A cigarette filter that has a scavenging effect on smoking induced gas phase free radicals. The filter ingredients are comprised of proanthocyanidins and include, but are not limited to, extracts of barks of pine tree, extracts of cones of cypress trees, extracts of grape seeds, and any combination thereof. Also, vitamin C and other known antioxidant ingredients may be added.

Abstract: Sexual wellness or sexual fitness is enhanced over time by administrating on a daily basis a source of proanthocyanidins and a source of arginine. Both sources may be blended into a composition or taken separately from a kit. The source of arginine may be a salt or peptide of L-arginine and aspartic acid such as arginine aspartate. The proanthocyanidins stimulate an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substration that is the source of the arginine. A sufficient amount of the nitric oxide is released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the combination may contain as a further ingredient a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer.

Abstract: A method for reducing blood glucose levels in patients with diabetes mellitus using as pharmaceutically effective agent a plant extract containing a high percentage of proanthocyanidins is provided. The method includes administering to hyperglycemic patients a proanthocyanidins containing plant extract in preparations suitable for oral intake in a dosage that is therapeutically effective to decrease elevated glucose levels or elevated glycosylated hemoglobin levels in blood of diabetics.

Abstract: Use of proanthocyanidins as an active ingredient of a stimulator and L-arginine or its salts as a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates the guanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles. Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type from reducing an amount of the cyclic guanosine monophosphate.

Abstract: Use of proanthocyanidins as an active ingredient of a stimulator as a source of arginine and a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates theguanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles. Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type5 from reducing an amount of the cyclic guanosine monophosphate. The substrate may be amino acid L-arginine, arginine salts or a dipeptide of arginine and aspartic acid.

Abstract: A cigarette filter that has a scavenging effect on smoking induced gas phase free radicals. The filter ingredients are comprised of proanthocyanidins and include, but are not limited to, extracts of barks of pine tree, extracts of cones of cypress trees, extracts of grape seeds, and any combination thereof. Also, vitamin C and other known antioxidant ingredients may be added.

Abstract: Use of proanthocyanidins as an active ingredient of a stimulator and L-arginine or its salts as a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates the guanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles. Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type from reducing an amount of the cyclic guanosine monophosphate.

Abstract: The invention relates to a process for producing a preparation containing the polyphenols of green tea (Thea chinensis) in readily available, unoxidised form, in which fresh green tea leaves are cooled until the activity of the phenol oxidases therein has dropped to at most 1% of the value at normal temperature and at the same time or immediately afterwards the water acting as the reaction medium is removed. Products made by this process are packed in capsules soluble in hot water.

Abstract: A method of inhibiting platelet aggregation with an agent which is able to normalize and enhance platelet reactivity without adversely affecting the bleeding time. The method additionally prevents adrenaline-induced platelet aggregation.