Patents by Inventor Peter Roy Clements

Peter Roy Clements has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycosylation variants of iduronate 2-sulfatase
    Patent number: 6541254
    Abstract: The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver. The present invention also provides an enzymatically active polypeptide fragment or variant of such a highly glycosylated iduronate-2-sulfatase. The present invention further provides an isolated nucleic acid encoding iduronate-2-sulfatase, as well as an expression vector, a host cell and a method for producing the present highly glycosylated iduronate-2-sulfatase enzyme.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: April 1, 2003
    Assignee: Women's and Children's Hospital
    Inventors: Peter J. Wilson, Charles Phillip Morris, Donald Stewart Anson, Teresa Occhiodoro, Julie Bielicki, Peter Roy Clements, John Joseph Hopwood
  • Synthetic &agr;-L-iduronidase and genetic sequences encoding same
    Patent number: 6524835
    Abstract: The present invention relates generally to &agr;-L-iduronidase and to genetic sequences encoding same. More particularly, the present invention provides an isolated nucleic acid molecule comprising a sequence of nucleotides which encodes or are complementary to a sequence which encodes a mammalian &agr;-L-iduronidase or fragment or derivative thereof and to the recombinant enzyme encoded thereby. These molecules are useful in the investigation, diagnosis and treatment of subjects suspected of or suffering from &agr;-L-iduronidase deficiency.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: February 25, 2003
    Assignee: Women's and Children's Hospital
    Inventors: Hamish Steel Scott, Donald Stewart Anson, Annette Marie Orsborn, Paul Victor Nelson, Peter Roy Clements, Charles Phillip Morris, John Joseph Hopwood
  • Synthetic &agr;-L-iduronidase and genetic sequences encoding same
    Patent number: 6238662
    Abstract: The present invention relates generally to &agr;-L-iduronidase and to genetic sequences encoding same. More particularly, the present invention provides an isolated nucleic acid molecule comprising a sequence of nucleotides which encodes or are complementary to a sequence which encodes a mammalian &agr;-L-iduronidase or fragment or derivative thereof and to the recombinant enzyme encoded thereby. These molecules are useful in the investigation, diagnosis and treatment of subjects suspected of or suffering from &agr;-L-iduronidase deficiency.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: May 29, 2001
    Assignee: Women's and Children's Hospital
    Inventors: Hamish Steel Scott, Donald Stewart Anson, Annette Marie Orsborn, Paul Victor Nelson, Peter Roy Clements, Charles Phillip Morris, John Joseph Hopwood
  • Glycosylation variants of iduronate 2-sulfatase
    Patent number: 6153188
    Abstract: The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver. The present invention also provides an enzymatically active polypeptide fragment or variant of such a highly glycosylated iduronate-2-sulfatase. The present invention further provides an isolated nucleic acid encoding iduronate-2-sulfatase, as well as an expression vector, a host cell and a method for producing the present highly glycosylated iduronate-2-sulfatase enzyme.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: November 28, 2000
    Assignee: Women's and Children's Hospital
    Inventors: Peter J. Wilson, Charles Phillip Morris, Donald Stewart Anson, Teresa Occhiodoro, Julie Bielicki, Peter Roy Clements, John Joseph Hopwood
  • Synthetic .alpha.-L-iduronidase and genetic sequences encoding same
    Patent number: 6149909
    Abstract: The present invention relates generally to .alpha.-L-iduronidase and to genetic sequences encoding same. More particularly, the present invention provides an isolated nucleic acid molecule comprising a sequence of nucleotides which encodes or are complementary to a sequence which encodes a mammalian .alpha.-L-iduronidase or fragment or derivative thereof and to the recombinant enzyme encoded thereby. These molecules are useful in the investigation, diagnosis and treatment of subjects suspected of or suffering from .alpha.-L-iduronidase deficiency.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: November 21, 2000
    Assignee: Women's and Children's Hospital
    Inventors: Hamish Steele Scott, Donald Stewart Anson, Annette Marie Orsborn, Paul Victor Nelson, Peter Roy Clements, Charles Phillip Morris, John Joseph Hopwood
  • Glycosylation variants of iduronate 2-sulfatase
    Patent number: 5932211
    Abstract: The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver. The present invention also provides an enzymatically active polypeptide fragment or variant of such a highly glycosylated iduronate-2-sulfatase. The present intention further provides an isolated nucleic acid encoding iduronate-2-sulfatase, as well as an expression vector, a host cell and a method for producing the present highly glycosylated iduronate-2-sulfatase enzyme.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: August 3, 1999
    Assignee: Women's and Children's Hospital
    Inventors: Peter J. Wilson, Charles Phillip Morris, Donald Stewart Anson, Teresa Occhiodoro, Julie Bielicki, Peter Roy Clements, John Joseph Hopwood
  • Glycosylation variants of iduronate 2-sulfatase
    Patent number: 5798239
    Abstract: The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver. The present invention also provides an enzymatically active polypeptide fragment or variant of such a highly glycosylated iduronate-2-sulfatase. The present invention further provides an isolated nucleic acid encoding iduronate-2-sulfatase, as well as an expression vector, a host cell and a method for producing the present highly glycosylated iduronate-2-sulfatase enzyme.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 25, 1998
    Assignee: Women's and Children's Hospital
    Inventors: Peter J. Wilson, Charles Phillip Morris, Donald Stewart Anson, Teresa Occhiodoro, Julie Bielicki, Peter Roy Clements, John Joseph Hopwood
  • Glycosylation variants of iduronate 2-sulfatase
    Patent number: 5728381
    Abstract: The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver. The present invention also provides an enzymatically active polypeptide fragment or variant of such a highly glycosylated iduronate-2-sulfatase. The present invention further provides an isolated nucleic acid encoding iduronate-2-sulfatase, as well as an expression vector, a host cell and a method for producing the present highly glycosylated iduronate-2-sulfatase enzyme.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 17, 1998
    Inventors: Peter J. Wilson, Charles Phillip Morris, Donald Stewart Anson, Teresa Occhiodoro, Julie Bielicki, Peter Roy Clements, John Joseph Hopwood