Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals am acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid.

Abstract: In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and/or positioning of an intra-cardiac electrophysiological (EP) mapping basket or other EP mapping structure of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes and a statistical shape or other model of the EP mapping basket or other type of EP mapping structure, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex, and thereby permit accurate navigation within the heart and/or processing of data acquired using the EP mapping basket or other EP mapping structure.

Abstract: Electrographic flow mapping (EGF mapping) is a technique used for aiding catheter ablation when treating atrial fibrillation. Visualizing EGF fields during a cardiac catherization and ablation procedure is an important and necessary part of conducting the procedure. Several different visualization methods are described and disclosed herein that may be employed to visualize EGF fields and maps, including quiver plots, streamline plots, particle plots, particle trail plots, moving particle plots, and moving and fading particle plots.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to extract atrial signals from electrical signals acquired from a patient suffering from atrial fibrillation. The electrical signals acquired from the patient may be intra-cardiac signals or body surface electrode signals, or both. At least portions of QRS or QRS-T complexes corresponding to determined initial synchronization times are used to generate Fast Fourier Transforms (FFTs) corresponding to the extracted QRS complexes. A series of steps follow to generate isolated atrial signals corresponding to each electrical signal by subtracting generated reconstructed signals corresponding to each such electrical signal therefrom.

Abstract: Disclosed are various examples and embodiments of a Nitinol basket for an electrophysiological (EP) mapping catheter. In one embodiment, the Nitinol basket comprises a plurality of basket splines, each basket spline having a distalmost portion and a proximal end, where the distal tip is uninterruptedly contiguous and continuous with the distalmost portions of the basket splines and formed from the same piece, slab or ingot comprising Nitinol as the splines. In such an embodiment, the basket splines and distal tip are cut and formed from a same single length or piece of Nitinol tubing or a Nitinol hypotube. The respective distal portions of each of the Nitinol splines can be continuous and contiguous with, and connected to, the Nitinol distal tip, each spline being configured to extend outwardly away from an imaginary central axis of the Nitinol basket and its proximal end and distal portion to form a curved shape therebetween when the Nitinol basket is in an undeformed and deployed state.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to estimate the action potential wave propagation in a patient's heart, and subsequently to detect at least one location or type of at least one source of, or rotational phenomenon associated with, at least one cardiac rhythm disorder using intracardiac electrodes and a modified multi-frame Horn-Schunck algorithm to generate a map corresponding to a spatial map, the map being configured to reveal on a monitor or display to a user the at least one location of the at least one source of the at least one cardiac rhythm disorder.

Abstract: Disclosed are various examples and embodiments of a cardiac mapping catheter configured for electrophysiological (EP) mapping and suitable for intravascular insertion in a patient's heart, and methods of making same. The cardiac mapping catheter comprises a plurality support arms having electrodes disposed thereon. Various configurations of the cardiac mapping catheter are described and disclosed which provide improved spatial resolution and sensing of EP signals acquired from inside a patient's heart.

Abstract: In some embodiments, there are provided systems, devices, components, and corresponding methods configured to permit navigation and or positioning of an intra-cardiac electrophysiological (EP) mapping basket of an EP mapping catheter inside or near an atrium or other heart chamber of a patient's heart using biosignals or intra-cardiac signals. In one embodiment, QRS complexes are extracted or isolated from intra-cardiac signals sensed by electrodes mounted on the EP mapping basket. Using the QRS complexes, one or more computing devices then determine the locations of the electrodes inside or near the patient's atrium that are associated with each isolated or extracted QRS complex. The one or more computing devices can also be used to determine changes in the three-dimensional locations and orientations of the basket and the electrodes thereof as the basket is moved around, in, or near the patient's atrium, heart chamber, or other portion of the patient's heart.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart.

Abstract: The present invention concerns a Medical system tor mapping of action potential data comprising an elongated medical mapping device (1) suitable for intravascular insertion having an electrode assembly (80) located at a distal portion (3) of the mapping device (1), a data processing and control unit (15) for processing data received from the mapping device (1), the data processing and control unit including a model generator for visualizing a 3-dimensional heart model based on one of electrical navigation system, MRI or CT scan data of a heart, a data output unit (16) for displaying both the 3-dimensional heart model and the processed data of the mapping device (1) simultaneously in a single visualization, wherein the model generator is configured to structure 3D scan data of the heart into 6 directions (a, b, c, d, e or f) of a cube, each direction is associated with a separate Cartesian coordinate system with X(a, b, c, d, e or f), Y(a, b, c, d, e or f), Z(a, b, c, d, e or f) coordinates, wherein for assign

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to classify, and to detect at least one location or type of at least one source of, at least one cardiac rhythm disorder in a patient's heart using one or more body surface electrodes, and/or intracardiac electrodes. Body surface electrogram data, and optionally intracardiac electrode data, representative of cardiac signals acquired from the patient are provided to a computing device, which in turn determines the location and type of the at least one source of the at least one cardiac rhythm disorder in the patient's heart using electrographic flow (EGF) methods, and then classifies same using electrographic volatility index (EVI) methods.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from a patient's body surface, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2D map, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2D map.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart, such as atrial fibrillation, and to classify same. Velocity vector maps reveal the location of the source of the at least one cardiac rhythm disorder in the patient's heart, which may be, by way of example, an active rotor in the patient's myocardium and atrium. The resulting velocity vector map may be further processed and/or analyzed to classify the nature of the patient's cardiac rhythm disorder, e.g., as Type A, B or C atrial fibrillation. The resulting cardiac rhythm classification then can be used to determine the optimal, most efficacious and/or most economic treatment or surgical procedure that should be provided to the individual patient. A simple and computationally efficient intra-cardiac catheter-based navigation system is also described.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals am acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid.

Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect the locations of sources of cardiac rhythm disorders in a patient's heart, and then to generate an estimate or probability of the patient being free from atrial fibrillation. The various embodiments employ at least one computing device to process a plurality of electrogram surfaces through time to generate at least one electrographical flow (EGF) map, representation, pattern, or data set, and then process the at least one EGF map, representation, pattern, or data set to determine at least two of source activity levels, flow angle variability (FAV) levels, and active fractionation (AFR) levels corresponding thereto. On the basis of a combination of the determined at least two of source activity levels, FAV levels, and AFR levels, an electrographical volatility index (EVI) score or metric representative of the estimate or probability of the patient being free from AF is generated.

Abstract: An ear inspection device configured for being at least partially introduced into an external ear canal for determining an ear condition, such as temperature, in particular at the subject's eardrum, wherein the device comprises an infrared sensor unit configured for detecting infrared radiation from the ear, and an electronic imaging unit configured for capturing images based on radiation in the visible range from the ear, wherein the electronic imaging unit exhibits at least one optical axis arranged such that it can be radially offset within the ear canal, and wherein the infrared sensor unit exhibits a visual axis arranged such that it can be positioned centrically within the ear canal or radially offset within the same semicircle, especially the same quadrant, of the cross section of the ear canal.

Abstract: The present invention concerns a Medical system tor mapping of action potential data comprising an elongated medical mapping device (1) suitable for intravascular insertion having an electrode assembly (80) located at a distal portion (3) of the mapping device (1), a data processing and control unit (15) for processing data received from the mapping device (1), the data processing and control unit including a model generator for visualizing a 3-dimensional heart model based on one of electrical navigation system, MRI or CT scan data of a heart, a data output unit (16) for displaying both the 3-dimensional heart model and the processed data of the mapping device (1) simultaneously in a single visualization, wherein the model generator is configured to structure 3D scan data of the heart into 6 directions (a, b, c, d, e or 0 of a cube, each direction is associated with a separate Cartesian coordinate system with X(a, b, c, d, e or f), Y(a, b, c, d, e or f), Z(a, b, c, d, e or f) coordinates, wherein for assigni

Abstract: Disclosed are various examples of embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid.

Abstract: The present invention concerns an elongated medical device (1) suitable for intravascular insertion. Said device comprising a flexible elongated body (2) having a distal portion (3) with a distal end (4) and a proximal portion (5) and an optic force sensing assembly (20) disposed within said flexible elongated body (2) proximate said distal end.

Abstract: The present invention concerns a system (100) for analyzing electrophysiological data, especially intracardial electrogram data, the system (100) comprising a data processing and control unit (15) for processing the electrophysiological data, a data output unit comprising a data output screen (324) for displaying results of electrophysiological data analysis, wherein the data processing and control unit (15) being configured to receive electrophysiological data obtained from a mapping catheter assembly (110, 111) that comprises an electrode assembly (120, 80) with a plurality of n electrodes (82), each electrode (82) configured for measuring electrophysiological data in the form of electrogram signals.