Patents by Inventor Peter S. Borromeo

Peter S. Borromeo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ring modified cyclic peptide analogs
    Publication number: 20040068094
    Abstract: A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.
    Type: Application
    Filed: September 30, 2003
    Publication date: April 8, 2004
    Inventors: Peter S. Borromeo, Jeffrey D. Cohen, George S. Gregory, Stacy K. Henle, Stephen A. Hitchcock, Louis N. Jungheim, Daniel R. Mayhugh, Timothy A. Shephered, William W. Turner
  • Cyclic peptide antifungal agents and methods of making and using
    Patent number: 5786325
    Abstract: Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## where: R', R", R'", R.sup.x1, R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3, R.sup.y4, and R.sup.0 are as defined above; andR.sup.2 is ##STR2## each R.sup.2a is independently hydroxy, halo, nitro, amino, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkylthio;a is 1, 2, 3 or 4;R.sup.3 is C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or --O--(CH.sub.2).sub.m --?O--(CH.sub.2).sub.n !.sub.p --O--(C.sub.1 -C.sub.12 alkyl);m is 2, 3 or 4;n is 2, 3 or 4; andp is 0 or 1;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: July 28, 1998
    Assignee: Eli Lilly and Company
    Inventors: Peter S. Borromeo, William W. Turner, Jr.
  • Cyclic peptide antifungal Agents
    Patent number: 5646111
    Abstract: Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein: R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;R" and R'" are independently methyl or hydrogen;R.sup.x1, R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3, and R.sup.y4 are independently hydroxy or hydrogen;R.sub.0 is a group of the formula ##STR2## R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, phenyl, p-halo-phenyl, p-nitrophenyl, phenoxy, benzyl, p-halo-benzyl, or p-nitro-benzyl; andR.sub.2 is an acyl side chain as defined herein.
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: July 8, 1997
    Assignee: Eli Lilly and Company
    Inventors: Peter S. Borromeo, James A. Jamison, Michael J. Rodriguez, William W. Turner, Venkatraghaven Vasudevan