Patents by Inventor Peter S. Klein

Peter S. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190167728
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Application
    Filed: January 31, 2019
    Publication date: June 6, 2019
    Inventors: Peter S. Klein, Jian Huang
  • Publication number: 20170065640
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 9, 2017
    Inventors: Peter S. Klein, Jian Huang
  • Patent number: 9452187
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: September 27, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Peter S. Klein, Jian Huang
  • Publication number: 20150272995
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Application
    Filed: March 30, 2015
    Publication date: October 1, 2015
    Inventors: Peter S. Klein, Jian Huang
  • Patent number: 9050315
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: June 9, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Peter S. Klein, Jian Huang
  • Publication number: 20110251593
    Abstract: The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The present invention also provides a system and method for the ex vivo culturing of HSCs, where an mTOR inhibitor is combined with a GSK-3 inhibitor within the culturing conditions.
    Type: Application
    Filed: April 11, 2011
    Publication date: October 13, 2011
    Inventors: Peter S. Klein, Jian Huang
  • Publication number: 20100068308
    Abstract: Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing of amyloid precursor proteins to beta-amyloid (A?) peptides, which are now believed to be the principal cause of Alzheimer's disease, thereby providing methods useful for the prevention, inhibition or reversal of the disease. Also provided are methods of using agents that specifically target the ? isoform of GSK-3, which is responsible for APP processing, making such selective GSK-3?-specific inhibitors especially useful in the treatment, prevention, and possible reversal of Alzheimer's disease. Further provided are kits and screening methods associated with the present methods.
    Type: Application
    Filed: April 30, 2008
    Publication date: March 18, 2010
    Inventors: Christopher J. Phiel, Christina A. Wilson, Virginia M-Y. Lee, Peter S. Klein
  • Patent number: 7378111
    Abstract: Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing of amyloid precursor proteins to beta-amyloid (A?) peptides, which are now believed to be the principal cause of Alzheimer's disease, thereby providing methods useful for the prevention, inhibition or reversal of the disease. Also provided are methods of using agents that specifically target the ? isoform of GSK-3, which is responsible for APP processing, making such selective GSK-3?-specific inhibitors especially useful in the treatment, prevention, and possible reversal of Alzheimer's disease. Further provided are kits and screening methods associated with the present methods.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: May 27, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Christopher J. Phiel, Christina A. Wilson, Virginia M-Y. Lee, Peter S. Klein
  • Publication number: 20040110837
    Abstract: Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing of amyloid precursor proteins to beta-amyloid (A&bgr;) peptides, which are now believed to be the principal cause of Alzheimer's disease, thereby providing methods useful for the prevention, inhibition or reversal of the disease. Also provided are methods of using agents that specifically target the &agr; isoforn of GSK-3, which is responsible for APP processing, making such selective GSK-3&agr;-specific inhibitors especially useful in the treatment, prevention, and possible reversal of Alzheimer's disease. Further provided are kits and screening methods associated with the present methods.
    Type: Application
    Filed: February 19, 2003
    Publication date: June 10, 2004
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Christopher J. Phiel, Christina A. Wilson, Virginia M-Y. Lee, Peter S. Klein
  • Patent number: 6441053
    Abstract: A method of identifying inhibitors of glycogen synthase kinase-3 is provided. The method comprises providing a mixture comprising GSK-3, a phosphate source, and a GSK-3 substrate, incubating the mixture in the presence or absence of a test compound, and assessing the activity of GSK-3 in the mixture. A reduction of GSK-3 activity following incubation of the mixture in the presence of the test compound is an indication that the test compound is an inhibitor of GSK-3.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: August 27, 2002
    Assignees: The Trustees of the University of Pennsylvania, President and Fellows of Harvard University
    Inventors: Peter S. Klein, Douglas Melton
  • Publication number: 20010052137
    Abstract: The invention relates to polypeptides which inhibit the activity of glycogen synthase kinase-3 beta (GSK-3 beta) in vivo and which also activate wnt signaling. The polypeptides have an amino acid sequence which includes one or both of an axin/GSK-3 beta interaction domain (GID) and an axin/axin interaction domain (AID). These polypeptides are useful for treating a number of disorders (e.g. bipolar disorder, mania, depression, Alzheimer's disease, diabetes, and leukopenia) which are presently treated by administration of lithium. The invention also includes antibodies (including fragments of antibodies) which bind specifically with the polypeptides described in the disclosure, and to transgenic mice which comprise a transgene encoding such polypeptides.
    Type: Application
    Filed: March 1, 2001
    Publication date: December 13, 2001
    Applicant: Trustees of the University of Pennsylvania
    Inventor: Peter S. Klein