Patents by Inventor Peter S. Mezes

Peter S. Mezes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel proteins and nucleic acids encoding same
    Publication number: 20080171046
    Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: May 12, 2004
    Publication date: July 17, 2008
    Inventors: Corine Vermet, Elma Fernandes, Richard Shimkets, John Herrmann, Kumud Majumder, John MacDougall, Vishnu Mishra, Peter S. Mezes, Luca Rastelli
  • Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72
    Patent number: 7179899
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: February 20, 2007
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V. S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Novel polypeptides and nucleic acids encoding same
    Publication number: 20040121380
    Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: October 20, 2003
    Publication date: June 24, 2004
    Inventors: Raymond J. Taupier, Kumud Majumder, Steven K. Spaderna, Glennda Smithson, Peter S. Mezes, Corine A.M. Vernet
  • Novel proteins and nucleic acids encoding same
    Publication number: 20040086875
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 6, 2004
    Inventors: Michele L. Agee, John P. Alsobrook, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Amitabha Chaudhuri, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Linda Gorman, Valerie Gerlach, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Li Li, Uriel M. Malyankar, John R. MacDougall, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Chean Eng. Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Steven K. Spaderna, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Bryan D. Zerhusen, Mei Zhong
  • Novel human proteins, polynucleotides encoding them and methods of using the same
    Publication number: 20040068095
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 13, 2002
    Publication date: April 8, 2004
    Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres, Weizhen Ji
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067882
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 5, 2002
    Publication date: April 8, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong
  • Novel human proteins, polynucleotides encoding them and methods of using the same
    Publication number: 20040048245
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 5, 2001
    Publication date: March 11, 2004
    Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040038230
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 4, 2002
    Publication date: February 26, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Andrei Chapoval, Amitabha Chaudhuri, Shlomit R. Edinger, Andrew Eisen, Esha A. Gangolli, Valerie Gerlach, Xiaojia Sasha Guo, Weizhen Ji, Nikolai V. Khramtsov, Mario W. Leite, Li Li, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Daniel K. Rieger, Kerry E. Quinn Senger, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040029226
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 6, 2003
    Publication date: February 12, 2004
    Inventors: John Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Ammitabha Chaudhuri, Steven D. Colman, Shlomit R. Edinger, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Sasha Guo, Ramesh Kekuda, Li Li, Timothy Z. MacLachlan, Uriel M. Malyankar, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John A. Peyman, Xiaozhong Qian, Luca Rastelli, Daniel K. Rieger, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Sujatha Sukumaran, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
  • Novel human proteins, polynucleotides encoding them and methods of using the same
    Publication number: 20040014058
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 1, 2002
    Publication date: January 22, 2004
    Inventors: John P. Alsobrook, Catherine E. Burgess, Elina Catterton, John S. Chant, Ammitabha Chaudhuri, Shlomit Edinger, Valerie Gerlach, Loic Giot, Linda Gorman, Xiaojia (Sasha) Guo, Ramesh Kekuda, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Meera Patturajan, Daniel K. Rieger, Kimberly A. Spytek, Raymond J. Taupier, Bryan D. Zerhusen, Haihong Zhong, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040006205
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: April 2, 2002
    Publication date: January 8, 2004
    Inventors: Li Li, Valerie Gerlach, Xiaohong Liu, Charles E. Miller, Kimberly A. Spytek, Bryan D. Zerhusen, Carol E. A. Pena, Suresh G. Shenoy, Haihong Zhong, Glennda Smithson, Stacie J. Casman, Ferenc L. Boldog, Edward Z. Voss, Corine A. Vernet, John R. MacDougall, Luca Rastelli, David W. Anderson, Mei Zhong, Peter S. Mezes, Katarzyna Furtak, Meera Patturajan, Catherine E. Burgess, Uriel M. Malyankar, Richard A. Shimkets, Raymond J. Taupier, Schlomit Edinger, Ann Mazur
  • Novel human proteins, polynucleotides encoding them and methods of using the same
    Publication number: 20030236188
    Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
    Type: Application
    Filed: May 1, 2002
    Publication date: December 25, 2003
    Inventors: Kimberly A. Spytek, Li Li, Shlomit R. Edinger, David J. Stone, Xiaojia Sasha Guo, David W. Anderson, Meera Patturajan, Valerie Gerlach, Raymond J. Taupier, Carol E. A. Pena, Muralidhara Padigaru, Ramesh Kekuda, Linda Gorman, Bryan D. Zerhusen, Glennda Smithson, John R. MacDougall, Peter S. Mezes, John A. Peyman, Mei Zhong
  • Novel polypeptides and nucleic acids encoding same
    Publication number: 20030216308
    Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: June 17, 2002
    Publication date: November 20, 2003
    Inventors: David W. Anderson, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, John L. Herrmann, Li Li, Peter S. Mezes, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Raymond J. Taupier, Corine A.M. Vernet
  • Probing method for identifying antibodies specific for selected antigens
    Patent number: 6641999
    Abstract: This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have (1) high affinity animal VH and VL sequences which mediate TAG-72 binding and (2) human CH and CL regions. They are thought to produce significantly fewer side-effects when administered to human patients by virtue of their human CH and CL antibody domains. The nucleotide and amino acid sequences of VH&agr;TAG VH, CC46 VH, CC49VH, CC83 VH, and CC92 VH, and CC49VL, CC83 VL, and CC92 VL idiotype sequences are disclosed, as well as in vivo methods of treatment and diagnostic assay using these chimeric antibodies.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: November 4, 2003
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Brian Gourlie, Mark W. Rixon, W. H. Kerr Anderson
  • Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72
    Publication number: 20030165498
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Application
    Filed: September 25, 2002
    Publication date: September 4, 2003
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V.S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Novel polypeptides and nucleic acids encoding same
    Publication number: 20030148485
    Abstract: The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Application
    Filed: March 20, 2001
    Publication date: August 7, 2003
    Inventors: Raymond J. Taupier, Kumud Majumder, Steven K. Spaderna, Glennda Smithson, Peter S. Mezes, Corine A.M. Vernet
  • Novel proteins and nucleic acids encoding same
    Publication number: 20030087816
    Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclosed therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 5, 2001
    Publication date: May 8, 2003
    Inventors: Corine Vermet, Elma Fernandes, Richard Shimkets, John Herrmann, Kumud Majumder, John MacDougall, Vishnu Mishra, Peter S. Mezes, Luca Rastelli
  • Novel proteins and nucleic acids encoding same
    Publication number: 20030082757
    Abstract: Disclosed herein are acid sequences which encode polypeptides. Also disclosed are nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses thereapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: February 8, 2001
    Publication date: May 1, 2003
    Inventors: Raymond J. Taupier, Catherine E. Burgess, Muralidhara Padigaru, Velizar T. Tchernev, Vishnu S. Mishra, Stacie J. Casman, Robert A. Ballinger, Corine A.M. Vernet, Li Li, Kimberly A. Spytek, David P. Andrew, Peter S. Mezes
  • Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
    Patent number: 6495137
    Abstract: Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 17, 2002
    Assignee: The Dow Chemical Company
    Inventors: Peter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V. S. Kashmiri, Liming Shu, Eduardo A. Padlan
  • Novel proteins and nucleic acids encoding same
    Publication number: 20020155115
    Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 14, 2001
    Publication date: October 24, 2002
    Inventors: Corine A.M. Vernet, Elma R. Fernandes, Richard A. Shimkets, John L. Herrmann, Kumud Majumder, John R. MacDougall, Vishnu S. Mishra, Peter S. Mezes, Luca Rastelli