Abstract: The present disclosure relates, in part, to a kit including at least two prefilled syringes. The first prefilled syringe includes a dose of a hazardous agent in a first volume of a pharmaceutical composition comprising a pharmaceutically acceptable solvent.

Abstract: A jet injection device with a fluid chamber in a housing member for holding about 0.02 ml to about 3 ml of a medicament. An injection-assisting needle has an injection end that extends from the housing for inserting into a patient to a depth of up to about 5 mm. A force-generating source is configured to apply a pressure reaching about 100-1000 psi to the medicament in the chamber to expel the medicament through the injecting end of the needle.

Abstract: An injection device that comprises a chamber configured for containing a substance to be injected and a needle operatively associated with the chamber and having a length sufficient to deliver the substance to an intradermal injection site. A collar surrounds the needle, defining a collar cavity. The collar also has a peripheral forward skin-contacting surface that surrounds and is radially spaced from the needle and injection site by an area that is sufficiently large to allow a patient's skin to move into the collar cavity to properly position the needle for intradermal delivery of the substance to the injection site to allow spread of the injected substance under the skin while inhibiting or preventing backpressure within the skin from forcing the substance out through the injection site.

Abstract: A nozzle assembly adapted for an injector, includes a frangible plunger. The plunger has a first driving member and a second driving member connected to the first driving member and spaced apart therefrom by a predetermined gap using a frangible bridge. When a predetermined force is applied to the second driving member, it breaks the frangible bridge and moves the second driving member across the gap. This causes the second driving member to ram into the first driving member driving fluid out of the nozzle. Thereafter, as the second driving member is separated from the first driving member, the first driving member remains stuck in the chamber preventing reuse of the nozzle assembly.