Abstract: Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.

Abstract: Motion detection apparatuses are disclosed. The motion detection may be performed using one or more of a sub-window of a predetermined time window, a predetermined threshold value that is settable responsive to changes in one or more environmental factors, or a detection trigger. An apparatus includes a processor and an analog-to-digital converter (ADC) circuitry to sample a reflected predetermined pattern signal to generate reflected predetermined pattern samples. The processor captures collections of the reflected predetermined pattern samples corresponding to a predetermined time window and determines a sum of the collections or sub-collections. The processor determines an average of magnitudes of the determined sum and determines that a moving object is detected responsive to a predetermined threshold value.

Abstract: Motion detection using channel impulse response signals and related systems, methods, and apparatuses are disclosed. An apparatus includes an analog input terminal of a receiver processing circuitry, an analog to digital converter (ADC) circuitry, and a processor. The analog input terminal receives a reflected predetermined pattern signal provided by a receiver antenna. The ADC circuitry samples the reflected predetermined pattern signal received by the analog input terminal to generate reflected predetermined pattern samples. The processor determines an average of magnitudes of a sum of collections of the reflected predetermined pattern samples and determines whether a moving object is sensed responsive to the determined average and a predetermined threshold value.

Abstract: The invention relates to a single use container for pressurized liquid, in particular beer, comprising a receptacle providing a storage volume for the liquid, a top attachment unit which is arranged on top of the receptacle, and a fitting which is arranged sealingly in a filling hole that is formed in the receptacle for the feeding and tapping of liquid.

Abstract: The invention relates to a valve unit (26) comprising a cartridge and valve holder (1), which has means (6) for connecting the same to a cartridge protective housing (3), means (7; 36, 49) for sealingly fastening the same in a hole (10) that is provided for this purpose in a liquid receptacle (11) as well as a lateral, continuous hole (20), an internal housing (4), which is mounted in the cartridge and valve holder (1), in which a tapping tip (8) and a pressure-reducing valve unit (13, 14, 15, 16, 17, 18) are located at the end of the internal housing (4) facing the cartridge protective housing (3), wherein the pressure-reducing valve unit has a pressure-regulating chamber (13), wherein the pressure-regulating chamber (13) encompasses a connection to the interior of the liquid receptacle (11) via a continuous hole (19) in the internal housing (4) and the lateral, continuous hole (20) in the cartridge and valve holder (1), which [connection] is protected or can be blocked by a non-return valve.

Abstract: Methods and systems for automatically determining game content based upon dynamically adjusted individual skill levels are provided. Example embodiments provide an Electronic Gaming Engine (“EGE”), which includes a Dynamic Challenge Level Adjuster for supporting multi-player, individualized skill-based games. In one embodiment, the EGE comprises game flow logic; game content models, for example, question and answer (“Q&A”) challenge models; a Dynamic Challenge Level Adjuster; one or more scoring modules; challenge data; participant data; and an input/output interface. These components cooperate to determine and assign skill level indexes on an individual basis and to automatically present game content appropriate to each individual player's skill level.

Abstract: The invention relates to a single use cask for pressurised liquid, particularly beverages, with a cask bottom, a cask side wall and a cask lid, wherein a stand is formed on the cask bottom, and the cask side wall has an opening in which a single use tap is arranged, wherein the single use cask, by virtue of its height within a range of between 100 mm and 200 mm, preferably of between 125 mm and 175 mm, and particularly preferably of 160 mm, can be positioned upright in a conventional domestic fridge.

Abstract: The invention relates to a single use container for pressurised liquid, in particular beer, comprising a receptacle providing a storage volume for the liquid, a top attachment unit which is arranged on top of the receptacle, and a fitting which is arranged sealingly in a filling hole that is formed in the receptacle for the feeding and tapping of liquid.

Abstract: The invention relates to a disposable container for receiving and dispensing a coloured fluid by spraying, comprising a vessel which forms a storage volume for the coloured fluid and comprises a vessel base and a vessel wall, the vessel being closed by a cap, a pressure regulating unit which can be connected to a propellant reservoir being arranged on the cap, using which pressure regulating unit a propellant can be introduced into the storage volume in order to set therein a regulated overpressure relative to the environment, and a hose being arranged on the cap, via which hose a spray gun is connected to the storage volume.

Abstract: Methods and systems for automatically determining game content based upon dynamically adjusted individual skill levels are provided. Example embodiments provide an Electronic Gaming Engine (“EGE”), which includes a Dynamic Challenge Level Adjuster for supporting multi-player, individualized skill-based games. In one embodiment, the EGE comprises game flow logic; game content models, for example, question and answer (“Q&A”) challenge models; a Dynamic Challenge Level Adjuster; one or more scoring modules; challenge data; participant data; and an input/output interface. These components cooperate to determine and assign skill level indexes on an individual basis and to automatically present game content appropriate to each individual player's skill level.

Abstract: Methods and systems for automatically determining game content based upon dynamically adjusted individual skill levels are provided. Example embodiments provide an Electronic Gaming Engine (“EGE”), which includes a Dynamic Challenge Level Adjuster for supporting multi-player, individualized skill-based games. In one embodiment, the EGE comprises game flow logic; game content models, for example, question and answer (“Q&A”) challenge models; a Dynamic Challenge Level Adjuster; one or more scoring modules; challenge data; participant data; and an input/output interface. These components cooperate to determine and assign skill level indexes on an individual basis and to automatically present game content appropriate to each individual player's skill level.

Abstract: The invention relates to a disposable tap (1) for tapping liquid from a pressurized liquid container. Compared to prior art taps, the inventive disposable tap is modified so that it can be preferably placed in the upper area of the lateral wall of the liquid container. To this end, the tap comprises a lateral inlet opening (21) which is oriented downward when the tap is mounted and which is provided for coupling, in a sealing manner, to an ascending tube (34), and comprises elements (6, 7, 8), which control the entrance of liquid into the tap and to the outlet (of the tap hole) in an appropriate manner. The invention also relates to a liquid container with a corresponding opening (36) for and with this tap.

Abstract: A modular substrate processing system is provided for processing a flexible substrate. The system includes at least two process modules arranged adjacent to each other in a horizontal direction. The process modules include gas cushion rollers adapted for contactless guiding of the flexible substrate and for diverting the flexible substrate in vertical directions.

Abstract: A sputtering cathode (1) for coating processes in a vacuum chamber (18) comprises one at least single-piece target plate (2) mounted on a metallic diaphragm (3). On the side of the diaphragm (3) facing away from the target plate (2) is disposed a cooling agent channel with an inflow line (9) and an outflow line (10) for a cooling agent and a hollow space (7) for at least one magnet system (5). The magnet system (5) is disposed in a supporting tub (6) sealed against the diaphragm (3) and not exposed to the cooling agent. The entire configuration is disposed on a supporting structure (12).

Abstract: A system for thin film deposition on a flexible substrate having at least a first deposition region is described. The system includes a first chamber being based on a platform, wherein the first deposition region is within the first chamber, wherein the first chamber has a first support member configuration configured for supporting at least two different substrate guiding systems and wherein one substrate guiding system is supported by the first support member configuration, and wherein the platform is configured for at least two different deposition units and wherein one deposition unit of the at least two different deposition units is enclosed by the first chamber.

Abstract: A strip coating system includes a first pulley carrying a flexible metal or Al substrate wound up on the first pulley. A second, take-up, pulley is provided for taking up the coated substrate. The coating process is a continuous coating process, during which the first pulley and the second pulley are rotated to move the substrate continuously past a coating tool for depositing coating particles on a surface of the substrate. After having passed the coating section with a speed v, the substrate carrying a coating layer on the surface thereof passes an infrared spectroscopic measurement device for measuring the layer thickness of the coating layer. Feedback controls are provided to control one or more process parameters of the coating tool responsive to the measurement of the thickness of the coating layer detected by the measurement tool. Thus, an in situ online measurement of the thickness of the coating layer may be implemented.

Abstract: A measuring device includes several sequentially disposed coating chambers for measuring optical properties of coated substrates. These coating chambers are separated from one another by partitioning walls, whose free ends are located closely above the substrate. The substrate is preferably a continuous film. By measuring the reflection, the transmission, etc. of the substrate between the individual coating chambers, it becomes possible to carry out measurements within only partially completed layer systems. This yields advantages for the technical operation control of the coating process.

Abstract: Methods and systems for automatically determining game content based upon dynamically adjusted individual skill levels are provided. Example embodiments provide an Electronic Gaming Engine (“EGE”), which includes a Dynamic Challenge Level Adjuster for supporting multi-player, individualized skill-based games. In one embodiment, the EGE comprises game flow logic; game content models, for example, question and answer (“Q&A”) challenge models; a Dynamic Challenge Level Adjuster; one or more scoring modules; challenge data; participant data; and an input/output interface. These components cooperate to determine and assign skill level indexes on an individual basis and to automatically present game content appropriate to each individual player's skill level.

Abstract: Methods and systems for creating, managing, and operating electronic games are provided. Example embodiments provide a DVD game environment (“DGE”) that includes game flow logic, interactive DVD game content, enhanced methods of scoring and play, automatic skill level adjustment, and an electronic game board. In one embodiment, the DGE comprises DVD game logic with scoring management, game and participant state information, video and audio game content, and an electronic game board. These components provide functionality that can be incorporated into a DVD game that presents challenges for entertainment, education, training, or testing purposes. The DVD games produced thereby can automatically provide challenges based upon participants' skill levels and automatically detect the correctness or incorrectness of a response in order to maintain an electronic game board.

Abstract: The invention relates to a process and to a web deposition machine for coating a plastic substrate with at least one metal layer, in particular plastic foil for flexible, printed circuit boards, wherein before depositing a first layer onto a surface of the plastic substrate to be deposited, a non depositing pretreatment of this surface is performed. It is the object of the invention to provide a process as described above through which the adhesion of metal layers on a plastic substrate is improved. Furthermore, a web deposition machine shall be provided through which such process can be performed. The object is accomplished through a process so that the non depositing pretreatment is performed in two steps, thus in a first step in which the surface of the plastic substrate (2) is cleaned with a non reactive low energy plasma (14), and in a second step in which the surface of the plastic substrate (2) is activated through reactive high energy ion radiation (17).