Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: The invention relates to a multi-roller crusher for the comminuting of mineral mill-feed, whereby the crushing roll are provided with crushing teeth, extending in the circumferential and longitudinal axial directions. Viewed in plan, the crushing teeth are arranged on each crushing roller such that several serial crushing teeth groups are formed behind each other, the imagined connection lines of which run successively at an inclined angle to the plan (1?,2?) of each crushing roller outer edge in the direction of the crushing roller centre.

Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: New IL-5 receptor antagonists and methods of use are described, e.g., in the treatment of IL-5 receptor mediated disorders. The compounds include both monomers and dimers that were identified using one or more of alanine scans, lysine scans, other residue substitutions, and C- and N-terminal truncations and additions vis a vis the core sequence Val Asp Glu Cys Trp Arg Ile Ile Ala Ser His Thr Trp Phe Cys Ala Glu Glu-AF17121 (SEQ ID NO: 1) and shorter sequences and derivatives thereof.

Abstract: Novel compounds are provided that bind to G-CSFR. The novel compounds have a peptide chain approximately 6 to 40 amino acids in length that binds to G-CSFR. The compounds are useful as probes for affinity screening. In addition, the compounds have demonstrated agonist or antagonist activity for the G-CSFR, and are therefore useful in treatment of diseases including patients who suffer from a low white blood cell titer. Pharmaceutical compositions and methods of use are provided as well.

Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: Novel compounds are provided that bind to G-CSFR. The novel compounds have a peptide chain approximately 6 to 40 amino acids in length that binds to G-CSFR. The compounds are useful as probes for affinity screening. In addition, the compounds have demonstrated agonist or antagonist activity for the G-CSFR, and are therefore useful in treatment of diseases including patients who suffer from a low white blood cell titer. Pharmaceutical compositions and methods of use are provided as well.

Abstract: The invention relates to a multi-roller crusher for the comminuting of mineral mill-feed, whereby the crushing rollers are provided with crushing teeth, extending in the circumferential and longitudinal axial directions. Viewed in plan, the crushing teeth are arranged on each crushing roller such that several serial crushing teeth groups are formed behind each other, the imagined connection lines of which run successively at an inclined angle to the plan (1′,2′) of each crushing roller outer edge in the direction of the crushing roller centre.

Abstract: A device for crushing and screening bulk materials consists of a vertical impact mill with associated feeder, an air-charged separator, a discharge device for the final product and a conveyor for returning the insufficiently crushed bulk materials fraction to the crushing region. The vertical impact mill and the separator are arranged on a divided drive shaft, which can be coupled if necessary. The separator is arranged below the vertical impact mill and is designed as a distributor plate, possibly with guide blades. The air is introduced laterally or tangentially below the distributor plate. The finished materials fraction is discharged laterally or tangentially above the distributor plate and conveyed to separator (cyclone) which may be connected downstream. The insufficiently crushed bulk materials fractions are discharged through an outlet below the distributor plate in the base region of the separator.