Abstract: Disclosed is a method of preparing a solution adapted for administration by infusion, comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5 and optionally NaCl. Also disclosed is a method of treating a disease in a subject, comprising the step of administering to a subject in need thereof a reconstituted solution as disclosed.

Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): ?and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4·2H2O and Na2HPO4·2H2O, and wherein the quantity of the NaH2PO4·2H2O and Na2HPO4·2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4·2H2O and Na2HPO4·2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.

Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.

Abstract: The present invention relates to a method for preparing a lyophilized solid pharmaceutical composition comprising a) a compound having the formula (I): and/or a compound having the formula (II): and b) two different sodium phosphate salts, wherein the two different sodium phosphate salts are NaH2PO4.2H2O and Na2HPO4.2H2O, and wherein the quantity of the NaH2PO4.2H2O and Na2HPO4.2H2O present in the composition is chosen such that the molar ratio of both NaH2PO4.2H2O and Na2HPO4.2H2O to compound (I) or compound (II) ranges from 0.02 to 0.5.

Abstract: Compositions comprising derivatives of biopterin, useful for the treatment of traumatic brain injury, non-traumatic brain injury, elevated cranial pressure, and secondary brain injury.

Abstract: The present invention relates to a method of a method of treating a disease in a subject.

Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.

Abstract: The present invention relates to a method of preparing 4-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride dihydrate.

Abstract: The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical composition biopterin derivatives.

Abstract: The present invention relates to solid pharmaceutical compositions comprising biopterin derivatives as well as methods for obtaining such solid pharmaceutical compositions. The invention also relates to the solid pharmaceutical compositions of the invention for treating diseases.

Abstract: The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical composition biopterin derivatives.

Abstract: The present invention relates to solid pharmaceutical compositions comprising biopterin derivatives as well as methods for obtaining such solid pharmaceutical compositions. The invention also relates to the solid pharmaceutical compositions of the invention for treating diseases.

Abstract: In a method for operating an injection system for a combustion engine, in an operating situation in which fuel is not requested by combustion engine, a valve is operated during at least one time interval in such a way that no fuel injection takes place, a valve element being moved in relation to at least one valve body by operating the valve.

Abstract: The invention relates to compounds of formula het-X-AB containing a N-heteroaryl moiety “het”, which is linked via X=sulfur to the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl moiety AB of the formula (II). The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidase-related diseases and disorders and inhibition of platelet activation.

Abstract: A fuel injection system having a high-pressure accumulator, in which fuel may be stored at high pressure, at least one fuel injector via which the fuel located in the high-pressure accumulator may be injected into the combustion chamber of an internal combustion engine being connectable to the high-pressure accumulator. A high-pressure pump draws in fuel out of a leak fuel area, compresses it, and supplies it to the high-pressure accumulator, so that a high fuel pressure is built up therein during operation of the high-pressure pump. A return line having a regulating valve is implemented between the leak fuel area and the high-pressure accumulator, the regulating valve allowing a fuel flow from the leak fuel area into the high-pressure accumulator when the high-pressure pump is shut down.

Abstract: A common rail fuel injection system having a low-pressure region from which a high-pressure fuel pump acts on fuel with high pressure and delivers it to a high-pressure fuel accumulator from which fuel is supplied to injectors that inject the highly pressurized fuel into the combustion chamber of an internal combustion engine in which the high-pressure pump, the high-pressure fuel accumulator, and the injectors are associated with a high-pump, pressure region. In order to avoid undesirable delays in the starting of the internal combustion engine, a check valve device is connected between the low-pressure region and the high-pressure region so that when a negative pressure is generated in the high-pressure region, fuel flows from the low-pressure region into the high-pressure region.

Abstract: A fuel injection system having a high-pressure accumulator, in which fuel may be stored at high pressure, at least one fuel injector via which the fuel located in the high-pressure accumulator may be injected into the combustion chamber of an internal combustion engine being connectable to the high-pressure accumulator. A high-pressure pump draws in fuel out of a leak fuel area, compresses it, and supplies it to the high-pressure accumulator, so that a high fuel pressure is built up therein during operation of the high-pressure pump. A return line having a regulating valve is implemented between the leak fuel area and the high-pressure accumulator, the regulating valve allowing a fuel flow from the leak fuel area into the high-pressure accumulator when the high-pressure pump is shut down.

Abstract: The invention relates to compounds containing a N-heteroaryl moiety, which is linked via oxygen, sulfur or nitrogen, or via a methylene bridge and oxygen, sulfur or nitrogen to a fused ring moiety, in particular to the 1,2,3-triazolo[4,5d]pyrimidine-7-yl radical. The invention also relates to a process for the preparation of said compounds and the use thereof in drugs for the treatment of NAD(P)H oxidases-related diseases and disorders and inhibition of platelet activation.

Abstract: A common rail fuel injection system having a low-pressure region from which a high-pressure fuel pump acts on fuel with high pressure and delivers it to a high-pressure fuel accumulator from which fuel is supplied to injectors that inject the highly pressurized fuel into the combustion chamber of an internal combustion engine in which the high-pressure pump, the high-pressure fuel accumulator, and the injectors are associated with a high-pressure region. In order to avoid undesirable delays in the starting of the internal combustion engine, a check valve device is connected between the low-pressure region and the high-pressure region so that when a negative pressure is generated in the high-pressure region, fuel flows from the low-pressure region into the high-pressure region.