Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: An attachment for a portable power tool, in particular a screwdriver machine or drilling machine, wherein the attachment has a drive part with a drive element and an output part with an output element for driving a work tool, wherein the drive element is able to be coupled to a machine output element of the portable power tool in order to drive the attachment and is connected or coupled to the output element via a transmission for driving the output element, and wherein the drive part has, on a drive side, a fastening device for releasably fastening the attachment to the portable power tool for conjoint rotation with respect to an angle positioning axis. Provision is made for the output part to be rotatable about the angle positioning axis relative to the drive part into at least two mutually different angle positions.

Abstract: A computing device includes an optical network transceiver and a basic input/output system (BIOS). The optical network transceiver is to connect to an optical network and to generate an event indicating that an optical signal strength has attenuated below a threshold. The BIOS is to determine generation of the event by the optical network transceiver, and responsively detect occurrence of a potential optical network intrusion attack. In response to detecting occurrence of the potential optical network intrusion attack, the BIOS is to perform an action to protect the computing device from the potential optical network intrusion attack.

Abstract: A gateway device includes a host-facing network interface to connect to a network interface of a host device at which remote management functionality of the host device is exposed. The gateway device includes a network-facing network interface to connect to a network. The gateway device includes a processor, and a memory storing program code executable by the processor to securely manage access over the network to the remote management functionality of the host device.

Abstract: An example redundant power supply system comprises a power supply input to receive power from a power supply; a buck-boost converter coupled to the power supply input; and a controller coupled to the buck-boost converter. The controller is to receive a power supply identification signal from the power supply. The controller is also to enable or disable the buck-boost converter based on the power supply identification signal.

Abstract: In some examples, a computing device can include a memory resource storing instructions to cause a processing resource to detect a hardware event associated with the computing device, generate an alert standard format (ASF) message associated with the hardware event, and transmit the ASF message to a microcontroller to cause the microcontroller to transmit the ASF message to an external computing device.

Abstract: An example of a controller for bus endpoint isolation can include an interface to couple to a bus that has respective communication channels and respective switches corresponding to endpoints of the bus, a processing resource, and a memory resource storing non-transitory instructions executable by the processing resource to select a first endpoint of the endpoints to receive a message from the interface via a first switch on a first communication channel associated with the first endpoint, cause, via a switch control mechanism, a second switch associated with a second endpoint of the bus to open to isolate the second switch; and responsive to causing the second switch to open, send the message via the first communication channel and the first switch to the first endpoint.

Abstract: A host device has a hardware-based remote control mode and a softwarebased remote control mode. The availability of each of the hardware- and software-based remote control modes is monitored. Client device remote control of the host device is selectively switched between the hardware- and softwarebased remote control modes, based on the monitored availability of each remote control mode.

Abstract: A power tool device, in particular a screwing and/or drilling device, including a drive unit for a rotational driving of a tool, in particular a drill or a screwdriver blade. The power tool device is adapted to detect at least one drive variable (AG) during the rotational driving of the tool, in which the drive variable (AG) is the torque acting on the tool and/or a drive variable associated with this torque, for example an electrical drive variable of the drive unit. The power tool device is adapted to determine a change criterion during the rotational driving of the tool on the basis of the at least one detected drive variable (AG) and to change the rotational driving of the tool in response to the detected drive variable (AG) satisfying the change criterion.

Abstract: In some examples, a power adapter for sharing redundant power comprises a primary power input; a redundant power input; a redundant power supply identification signal (RPS ID) input; and a controller coupled to the RPS ID input. The controller is to direct power from the primary power input to an electronic device; direct power from the redundant power input to the electronic device, to another power adapter, or both; modify an RPS ID from the RPS ID input in response to directing power from the redundant power input to the electronic device; and output the modified RPS ID to the another power adapter.

Abstract: An assistance apparatus for a hand-held tool apparatus, in particular a screwing and/or drilling apparatus, that includes a fastening unit for detachable fastening of the assistance apparatus to the tool apparatus, and an electrical assistance device, which is designed to provide an assistance function for supporting a machining operation of the tool apparatus. The electrical assistance device includes an assistance apparatus communication unit for communication with the tool apparatus.

Abstract: Examples are described herein for dynamically allocating shared bus lanes provided by a peripheral component bridge. A multiplexor may be operably coupled with the bridge via the shared bus lanes. A plurality of peripheral component slots may each be operably coupled with the multiplexor via a respective plurality of peripheral bus lanes. The multiplexor may multiplex the shared bus lanes to multiple different peripheral component slots. Circuitry may: interrogate each of the peripheral component slots to obtain information about a modular component installed in the peripheral component slot, wherein the information about the modular component includes a usable range of bus lanes and a transmission speed capability; and cause the multiplexor to dynamically allocate the number of shared bus lanes to the respective pluralities of peripheral bus lanes of the peripheral component slots based on the usable ranges and transmission speed capabilities of the installed modular components.

Abstract: A read-only memory (ROM) stores firmware code for a hardware component. A firmware controller is directly physically connected to the hardware component and to the ROM. The firmware controller exposes a virtual ROM link to the hardware component. The hardware component accesses the firmware code over the virtual ROM link exposed by the firmware controller.

Abstract: A power monitoring adapter may include a plurality of power supply unit (PSU) inputs to couple a plurality of PSUs to the power monitoring adapter. The power monitoring adapter may also include a power output to electrically couple the power monitoring adapter to a powered system. The power output includes a voltage line, and a ground. Further, the power monitoring adapter may include a side band interface to couple to the powered system. The side band interface communicates status data of the number of PSUs coupled to the power monitoring adapter.

Abstract: An attachment (110) for a hand-held power tool (200), in particular a screwdriver or drill, wherein the attachment (110) has an attachment housing (113) and a drive element (123) on a drive side (111), which drive element can be coupled to a machine output element (221) of the hand-held power tool (200) in order to drive the attachment (110) and is firmly connected to an output element (120A) of the attachment (110) or is motion-coupled via a gear (530) in order to drive a working tool (242), wherein the attachment (110) has a fastening device (105) on the drive side (111) for detachable fastening to the hand-held power tool (200), wherein the fastening device (105) has at least one support surface (232) that is stationary with respect to the attachment housing (113) for providing support on the hand-held power tool (200) in the direction of a support axis (ST) and at least one locking body (150) adjustable between a locking position and an unlocking position and loaded into the locking position by a spring a

Abstract: Handheld power tool having a housing with a machining axis along which a tool is or can be arranged, and having a lighting device that has at least one activatable lamp, the lighting device generating work light within a beam angle with an increased or maximum light intensity in a main emission direction in order to illuminate a work region, and having at least one light sensor for measuring the light intensity, characterized in that the light sensor detects the light intensity of the work light reflected on the work region during operation and generates control signals representing the light intensity, in that an adjustment unit is provided for setting and/or adjusting the work light generated by the lighting device, and in that a control unit is provided which controls the adjustment unit on the basis of the sensor signals during operation.

Abstract: An attachment for a portable power tool, in particular a screwdriver machine or drilling machine, wherein the attachment has a drive part with a drive element and an output part with an output element for driving a work tool, wherein the drive element is able to be coupled to a machine output element of the portable power tool in order to drive the attachment and is connected or coupled to the output element via a transmission for driving the output element, and wherein the drive part has, on a drive side, a fastening device for releasably fastening the attachment to the portable power tool for conjoint rotation with respect to an angle positioning axis. Provision is made for the output part to be rotatable about the angle positioning axis relative to the drive part into at least two mutually different angle positions.

Abstract: An autoclavable human interface device is described. The autoclavable human interface device can include a first component constructed of a first material exposable to autoclave conditions without damage caused to the first component. The autoclavable human interface device can include a second component constructed of a second material that is susceptible to damage under the autoclave conditions. The autoclavable human interface device can include a component coating on the second component. The component coating can be exposable to the autoclave conditions without allowing damage to the second component.

Abstract: An example apparatus comprising a heat dissipation mechanism and a controller to detect a temperature of a surface of the apparatus, in response to detecting that an audio output device is connected to the apparatus, determine a thermal profile, and instruct the heat dissipation mechanism to dissipate heat from the apparatus based on the thermal profile.

Abstract: An example of a controller for bus endpoint isolation can include an interface to couple to a bus that has respective communication channels and respective switches corresponding to endpoints of the bus, a processing resource, and a memory resource storing non-transitory instructions executable by the processing resource to select a first endpoint of the endpoints to receive a message from the interface via a first switch on a first communication channel associated with the first endpoint, cause, via a switch control mechanism, a second switch associated with a second endpoint of the bus to open to isolate the second switch; and responsive to causing the second switch to open, send the message via the first communication channel and the first switch to the first endpoint.