Abstract: The present disclosure concerns aptamers of formula (I) capable of specifically binding to Factor XIa. The aptamers can be used to prevent, treat or alleviate the symptoms of thrombosis. The aptamers can also be used to detect Factor XIa in a sample and/or purify Factor XIa from a sample. The aptamers can further be used to identity putative therapeutic agents for the prevention, treatment or alleviation of symptoms associated with thrombosis.

Abstract: The present disclosure relates to monovalent antibodies and chimeric proteins (comprising the monovalent antibodies) for the treatment of an auto-immune inflammatory disorder or condition. The monovalent antibody moiety lacks a Fc region, is specific for an activating Fc receptor and is for limiting or avoiding the activation of an immune cell induced in the presence and upon the binding of a ligand of the activating Fc receptor to the activating Fc receptor. The monovalent antibodies and chimeric proteins are especially useful for the prevention, treatment or alleviation of symptoms associated with an auto-immune inflammatory disorder caused or maintained by the engagement of an auto-antibody having a Fc region capable of engaging the activating Fc receptor to mediate the pathological destructions of cells or tissues.

Abstract: The present disclosure concerns aptamers of formula (I) capable of specifically binding to Factor XIa. The aptamers can be used to prevent, treat or alleviate the symptoms of thrombosis. The aptamers can also be used to detect Factor XIa in a sample and/or purify Factor XIa from a sample. The aptamers can further be used to identity putative therapeutic agents for the prevention, treatment or alleviation of symptoms associated with thrombosis.

Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.

Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.

Abstract: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.

Abstract: Long-term changes in the distribution of a mineral in a subsurface deposit, due to commercial production of the mineral, are monitored by suitable instrumentation. The monitoring instrumentation is installed in combination with commercial mineral production equipment but the monitoring instrumentation is transparent to production. The monitoring instrumentation measures long-term changes in selected petrophysical attributes that are due to re-distribution of the mineral within the deposit in response to production.

Abstract: An auditorium has a domed roof formed by a first part spherical portion covering, without intermediate support, most of an amphitheatre accommodating an audience, and a second part spherical portion covering a stage adjacent the amphitheatre, the first portion being supported only at its periphery, and the second portion consisting of segmental leaves which can open about a common pivot supported by the first portion to uncover the stage, the common pivot being at a vertical axis of the second portion of the roof and above the amphitheatre and the vertical axis of the first portion being above the stage. Wall panels behind the stage can be moved apart to open the rear of the stage to the exterior.

Abstract: A structure is provided having two opposing nested pairs of outwardly convex roof arches mounted for rotation about a generally horizontal axis. Each pair of nested roof arches can be rotated about its axis from a lowered nested condition to a raised condition where the inner portion of one arch partially overlaps the other arch of the nested pair. In a preferred arrangement the arches extend between supports on diametrically opposing sides of a stadium building, which has an upper opening. The arches in their raised condition cover the stadium opening and in their lowered condition maintain the stadium substantially open to the elements. The turning moment exerted by the arches is sustained through struts by floats within liquid contained in caissons forming a foundation of the structure. The floats are shaped and guided to follow a path within the liquid as the associated arch rotates such as to substantially balance the turning moment of the latter as they move.

Abstract: A structure is provided having two opposing nested pairs of outwardly convex roof arches mounted for rotation about a generally horizontal axis. Each pair of nested roof arches can be rotated about its axis from a lowered nested condition to a raised condition where the inner portion of one arch partially overlaps the other arch of the nested pair. In a preferred arrangemnt the arches extend between supports on diametrically opposing sides of a stadium building, which has an upper opening. The arches in their raised condition cover the stadium opening and in their lowered condition maintain the stadium substantially open to the elements. The turning moment exerted by the arches is sustained through struts by floats within liquid contained in caissons forming a foundation of the structure. The floats are shaped and guided to follow a path within the liquid as the associated arch rotates such as to substantially balance the turning moment of the latter as they move.