Abstract: Power industry boiler tube failures are a major cause of utility forced outages in the United States, with approximately 41,000 tube failures occurring every year at a cost of $5 billion a year. Accordingly, early tube leak detection and isolation is highly desirable. Early detection allows scheduling of a repair rather than suffering a forced outage, and significantly increases the chance of preventing damage to adjacent tubes. The instant detection scheme starts with identification of boiler tube leak process variables which are divided into universal sensitive variables, local leak sensitive variables, group leak sensitive variables, and subgroup leak sensitive variables, and which may be automatically be obtained using a data driven approach and a leak sensitivity function. One embodiment uses artificial neural networks (ANN) to learn the map between appropriate leak sensitive variables and the leak behavior.