Abstract: A treatment of sweat glands in a target region of skin includes generating electromagnetic radiation having a wavelength of about 1,064 nm to about 1,800 nm. To decrease sweat production in a plurality of sweat glands, the electromagnetic radiation is delivered to a dermal interface defined by a dermal region and a subcutaneous fat region in the target region of skin to cause thermal injury to at least one of the dermal region, the subcutaneous fat region or the dermal interface. An epidermal region of the skin can be cooled at least one of before, during or after delivering the electromagnetic radiation to the dermal interface in the target region of skin.