Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesis and/or purification of certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment, prophylaxis, and diagnosis, etc.

Abstract: Disclosed is a system (1100) to permit access and operation of a machine (100). The machine has a ignition switch arrangement (1152) actuable by at least user manipulation thereof and arranged to enable operation of the machine and at least one immobilizer arrangement (1150) connected with the ignition switch arrangement and configured to selectively inhibit or permit operation of the machine via the switch arrangement. The system comprises a proximity detection arrangement (1110, 1120) associable with the machine and adapted for detection and reading of at least one proximity identification device (1132) carried or worn by a user of the machine. A control arrangement (1122) is responsive to detection by the proximity detection arrangement of a valid device to thereby disarm the immobilizer arrangement. The proximity detection arrangement is at least operationally independent of the ignition switch arrangement and any key actuator (1400) thereof.

Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g.

Abstract: A control system for controlled exercise controls a functional electrical stimulation (FES) system which applies electrical signals to muscle groups of a user such as a user having a disability; the user exercises on a motor driven exercise machine such that substantially isokinetic exercise during a movement is obtained as the user's body part moves with a motor driven displaceable element of the machine. This element provides resistance to applied displacement load from the user's stimulated muscles. A feedback control system receives signals indicative of the user's performance and a control arrangement controls electrical stimulation to the user's muscles to achieve a desired exercise regime.

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

Abstract: A apparatus for assisting in flying, walking or swimming having wings, legs or fins attached to a drive mechanism in which the end of the wings, legs or fins are simultaneously oscillated and moved linearly generating lift or walk and swim movement.

Abstract: A durable holographically imaged paper, plastic film or other product is produced by embossing the image into a thermoplastic coating thereon which comprises plastic pigment particles. The plastic pigment particles are preferably hollow but may be solid. The coating preferably also comprises a thermoplastic polymer or copolymer, for example a copolymer of vinyl acetate and versatic acid, an acrylic polymer, a styrene-acrylic or other acrylic copolymer, a vinyl chloride-vinyl acetate-ethylene terpolymer, a polyvinyl acetate or a polyvinyl alcohol. Preferably, the polymer or copolymer has a glass transition temperature (Tg value) in the range 20° C. to 110° C. The thermoplastic coating may also contain inorganic pigments, for example precipitated calcium carbonate (PCC), ground natural calcium carbonate, or kaolin or other clays, and/or a starch binder. Embossing is preferably carried out directly on the thermoplastic coating by means of a holographically engraved shim.

Abstract: A liquid toner digital press imaging composition contains, in addition to the toner, a security ingredient which is a reactant reactable in use with a complementary reactant carried by a printable substrate, so as to be detectably retained in or on the substrate in the event of fraudulent alteration or removal of the image produced by the toner.

Abstract: Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.

Abstract: The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.

Abstract: A control system for controlled exercise controls a functional electrical stimulation (FES) system which applies electrical signals to muscle groups of a user such as a user having a disability; the user exercises on a motor driven exercise machine such that substantially isokinetic exercise during a movement is obtained as the user's body part moves with a motor driven displaceable element of the machine. This element provides resistance to applied displacement load from the user's stimulated muscles. A feedback control system receives signals indicative of the user's performance and a control arrangement controls electrical stimulation to the user's muscles to achieve a desired exercise regime.

Abstract: Casting paper of a desired surface texture or finish for use in the manufacture of artificial leather is produced by heating the polymer coating 1 of a polymer-coated paper 2 to a temperature sufficient to melt the polymer and then cooling the polymer coating from its molten state to a solid state as it passes through a nip between an embossing roll 3 having a surface configuration corresponding to said desired surface texture or finish and a backing roll 4, thereby to impart the surface configuration of the embossing roll to the polymer-coated paper. The polymer is preferably polyolefinic, for example poly (4-methyl-1-pentene) or a polypropylene/polyethylene blend. An anti-curl back-coat, for example of polyvinyl alcohol, can be applied after the embossing operation.

Abstract: Aqueous suspensions of papermaking fibres and filler are each separately treated with an anionic or a cationic polymer, after which the filler (preferably) or the papermaking fibre is treated with a polymer of opposite charge to that used in the initial treatment. The filler and papermaking suspensions are then mixed to form a papermaking stock, with dilution as necessary before, during or after the mixing operation. This stock is then used to form a loaded paper web in conventional manner. The initial treating polymer is preferably a papermaking retention aid or flocculant, e.g. a cationic polyarcylamide or an amine/amide/epichlorohydrin copolymer in the case of cationic materials or an anionic polyacrylamide in the case of anionic materials. The further treating polymer is preferably an anionic or cationic starch, depending on the charge of the initial treating polymer.

Abstract: Paper coated uniformly with discrete dots of remoistenable adhesive, especially based on starch or polyvinyl alcohol, has curl stability comparable with particle gum coated papers. Preferably, the dots are less than 0.3 mm in diameter and typically spaced 0.5 to 1 mm (centers) apart. The product is made by screen coating dots of aqueous adhesive mix onto base paper.

Abstract: Paper coated uniformly with discrete dots of remoistenable adhesive, especially based on starch or polyvinyl alcohol, has curl stability comparable with particle gum coated papers. Preferably, the dots are less than 0.3 mm in diameter and typically spaced 0.5 to 1 mm (centers) apart. The product is made by screen coating dots of aqueous adhesive mix onto base paper.

Abstract: In a process for the production of microcapsules containing a liquid fill material, a dispersion-stabilizing species is produced in an aqueous acidic medium by interaction of a melamine formaldehyde precondensate and a water soluble polymer, neither of which alone is dispersion stabilizing with respect to the liquid fill material, and the precondensate is condensed by acid catalysis to produce a condensate which separates from solution and enwraps the liquid fill material to produce microcapsules.

Abstract: Fibre recovery process for pressure-sensitive carbonless copying paper which comprises defibrating the wastage in aqueous media, preferably in the presence of a cationic quaternary ammonium surface active agent, treating the wastage with acid to destroy the microcapsules, and bleaching the defibrated wastage with a bleaching agent.