Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.

Abstract: A crystalline form of 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzoxazole is provided which is useful in the treatment of infections caused by Picornaviridae such as human rhinovirus (HRV), and in particular the crystal form is an anhydrous crystalline free base form of 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzoxazole. In addition, a method of manufacturing the free base crystalline form is also provided, including a step of micronizing the compound particles, optionally using a wetting agent, as well as pharmaceutical compositions incorporating the free base crystalline form such as tablets or suspensions, and methods of therapeutic treatments using this form and pharmaceutical compositions thereof.

Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.

Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.

Abstract: A processing system includes control circuitry to control the processing system, a remote management module to enable remote management of the processing system via a network, and an agent to operate as an intermediary between the remote management module and the control circuitry. The agent and the remote management module are configured to cooperatively implement an abstraction layer through which the agent and the remote management module communicate.

Abstract: A remote management module (RMM) can be configured, in one embodiment, via the processing system that the RMM is monitoring. In one embodiment, the present invention includes allowing a user access to a processing system being monitored by a RMM, and configuring the RMM without the user accessing the RMM.

Abstract: According to an embodiment of the invention, a remote management device is integrated into a processing system, such as a filer or other storage server, and the remote management device and administrative data (such as console data) generated by the processing system are accessible even if the processing system becomes inoperable. The processing system includes a console port that outputs administrative data in the form of administrative data during system operation. The remote management device is accessible remotely, for example through a local area network (LAN) or a wide area network (WAN) such as the Internet, or a combination of networks. The remote management device intercepts the administrative data output by the console port and stores the data into memory on the remote management device.

Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.

Abstract: A system is provided including a host processing system and a remote management module coupled to it. The host processing system includes a boot storage device storing a plurality of boot images to allow the remote management module to remotely select a boot image from the plurality of boot images and to remotely cause the host processing system to boot utilizing the selected boot image.

Abstract: The present invention is a method and system for indicating field replaceable unit status and configuration. A visible alert may be mounted on a card, in proximity to a location for a field replaceable unit. The visible alert may indicate a failed replaceable unit or a location for installation of a new replaceable unit. Supplemental power may be available on the card whereby a visible alert may be operable when an appliance, which contains the field replaceable unit, is powered down or when the card has been removed from the appliance. Additionally, an appliance in accordance with the present invention may include cards with visible alerts associated with field replaceable units. The visible alerts may be visible to an administrator without opening the chassis of the appliance.

Abstract: According to an embodiment of the invention, a remote management device is integrated into a processing system, such as a filer or other storage server, and the remote management device and administrative data (such as console data) generated by the processing system are accessible even if the processing system becomes inoperable. The processing system includes a console port that outputs administrative data in the form of administrative data during system operation. The remote management device is accessible remotely, for example through a local area network (LAN) or a wide area network (WAN) such as the Internet, or a combination of networks. The remote management device intercepts the administrative data output by the console port and stores the data into memory on the remote management device.

Abstract: Provided is a method and system for protecting data transactions transmitted on an integrated circuit bus. Specifically, by transmitting data along with the complement of the data from one component to another component that are connected by the integrated circuit bus, the data and complemented data can be compared for errors. Exemplary errors include bit flips. Comparisons include logical operations, such as XOR, that determine if an error has occurred during the transmission of the data or complemented data on the integrated circuit bus.

Abstract: A processing system includes control circuitry to control the processing system, a remote management module to enable remote management of the processing system via a network, and an agent to operate as an intermediary between the remote management module and the control circuitry. The agent and the remote management module are configured to cooperatively implement an abstraction layer through which the agent and the remote management module communicate.

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract: An injection valve is provided. A first conduit is disposed between first and second chambers of the valve. An entrance to the first conduit is located within the first chamber. A second conduit is concentrically disposed within the first conduit so that there is a first flow passage between the first and second conduits connecting the first and second chambers. The second conduit has an entrance communicating with the first chamber via the entrance of the first conduit and an exit defining a first outlet port of the valve. A cover opens and closes a first inlet port of the first chamber, and a biasing device biases the cover closed. An actuator moves the cover from the closed position to open the first inlet port.

Abstract: A hand-held chemical vapor detector for detecting biological substances in an indoor and outdoor setting is claimed. More specifically, the present invention relates to a plasma chromatograph (PC) vapor detector that is interfaced to a biological sample processing and transfer introduction system. The biological sample processing was accomplished by quartz tube thermal decomposition (TD), and the resultant vapor was transferred by gas chromatography (GC) to the PC detector. This system is comprised of a thermal decomposition module, gas chromatography module and a plasma chromatograph detector. These components are connected in a series fashion. The device is referred to as a Biological Classifier System (BCS). The BCS can be described as a hyphenated device where two analytical dimensions (the GC and PC), in series, allow the separation and isolation of individual components from the thermal decomposition of biological analytes.

Abstract: A hand-portable, modular and temperature programmable gas chromatography aratus having reduced power consumption requirements is disclosed. The gas chromatography module includes a ring oven for housing a gas chromatography capillary column and programmable means for controlling the temperature of said column within the ring. The gas chromatography capillary column includes a sampling end and an effluent end. The sampling end of the GC capillary column is in fluid communication with a sampling nozzle and a vacuum pulse generating means. The vacuum generating means generates a sample pulse and directs the sample pulse to the sampling end of the gas chromatography capillary column during sample injection mode. During standby mode only clean dry air is directed to the column. The module is also easily interfaced with secondary sample detection or analysis instruments so that additional identification dimensions can added.

Abstract: A chemical sampling apparatus including an interface between a miniature mobility spectrometer and a gas chromatography system. The apparatus has a gas chromatography an ion mobility spectrometer and an input for inputting a regulated flow of a gas to be analyzed to the gas chromatograph. An interface is positioned between the gas chromatograph and the ion mobility spectrometer. The interface accepts and analyzes eluted gas from the gas chromatograph and selectively inputs the eluted gas to the ion mobility spectrometer only when an eluted gas condition to be analyzed is detected.

Abstract: A heated capillary tube is axially supported in center of a housing under cuum. One end of the capillary tube receives ions from an ion source. The other end of the capillary tube terminates adjacent to the inner side of a flat plate having an orifice. A transport tube is connected to the outer side of the flat plate and has an open outer end. A first electrical field exists between the capillary tube and the plate to control the flow of ions. A second electrical field exists downstream of the plate, and the tube is disposed within the second electrical field. The transport tube allows for more efficient focusing of ions by the electrical and aerodynamic means to the mass spectrometer. A mechanical valve may be coupled to the capillary tube to independently control the flow of ions and the entire probe may be removed without compromising the vacuum in the mass spectrometer.

Abstract: A method and device for detecting bacteria by forming an immunoassay ladder sing a biological substance (Ag) adsorbed onto a surface, to which has been added an immunological biochemical ladder (Ab) and beta-galactosidase enzyme (gal) to form a Ag-Ab-gal system. The system is added to an aqueous solution of an enzyme selected from ortho-nitrophenylgalactopyranoside and ortho-nitrophenylgalactosidase enzyme. The enzyme reacts with the gal to produce ortho-nitrophenol (ONP) such that the amount of ortho-nitrophenol (ONP) produced may be detected by measuring the vapor pressure generated by the ONP using an ion mobility spectrometer monitor. The pressure of the ONP is in proportion to the amount of biological substance present in the system. In a preferred embodiment, the ion mobility spectrometer monitor includes display means for indicating the quantity of bacteria measured.