Abstract: The present invention relates to devices, systems and methods for spectrally identifying tissues and guiding the introduction of a probe, needle, and medical instrument into a body structure. The probe can further be used for precise delivery of therapeutic agents to selected regions of the body.

Abstract: Embodiments for controlling a gas turbine engine to minimize combustion dynamics and emissions are disclosed. Methods and an apparatus are provided for controlling the gas turbine engine where a compressor inlet temperature is measured and a turbine reference temperature is calculated in real-time and utilized to determine the most-efficient fuel splits and operating conditions for each of the fuel circuits. The fuel flow for the fuel circuits are then adjusted according to the identified fuel split.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: An inlet bleed heat and power augmentation system utilizing a bi-directional and common piping arrangement is disclosed. The piping arrangement includes a plurality of feed tubes arranged to communicate either steam to a compressor discharge plenum or compressed air from the compressor discharge plenum. Various embodiments of the invention are discussed including operation methods.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: A fuel supply system and method thereof that utilizes an off-gas in addition to the primary fuel to lower the emissions of a gas turbine combustion system is disclosed. The fuel supply system apparatus comprises a fuel gas supply conduit and an off-gas supply conduit in fluid communication with the fuel gas supply conduit such that the flow of an off-gas to the fuel gas supply conduit can be regulated as required by the operator to the desired fuel nozzle(s). The fuel gas supply preferably operates with natural gas and the off-gas supply preferably comprises the constituents hydrogen and methane.

Abstract: Embodiments for controlling a gas turbine engine to minimize combustion dynamics and emissions are disclosed. Methods and an apparatus are provided for controlling the gas turbine engine where a compressor inlet temperature is measured and a turbine reference temperature is calculated in real-time and utilized to determine the most-efficient fuel splits and operating conditions for each of the fuel circuits. The fuel flow for the fuel circuits are then adjusted according to the identified fuel split.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: An inlet bleed heat and power augmentation system utilizing a bi-directional and common piping arrangement is disclosed. The piping arrangement includes a plurality of feed tubes arranged to communicate either steam to a compressor discharge plenum or compressed air from the compressor discharge plenum. Various embodiments of the invention are discussed including operation methods.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: In the systems and methods of the present invention a multifocal multiphoton imaging system has a signal to noise ratio (SNR) that is reduced by over an order of magnitude at imaging depth equal to twice the mean free path scattering length of the specimen. An MMM system based on an area detector such as a multianode photomultiplier tube (MAPMT) that is optimized for high-speed tissue imaging. The specimen is raster-scanned with an array of excitation light beams. The emission photons from the array of excitation foci are collected simultaneously by a MAPMT and the signals from each anode are detected using high sensitivity, low noise single photon counting circuits. An image is formed by the temporal encoding of the integrated signal with a raster scanning pattern. A deconvolution procedure taking account of the spatial distribution and the raster temporal encoding of collected photons can be used to improve decay coefficient.

Abstract: A fuel supply system and method thereof that utilizes an off-gas in addition to the primary fuel to lower the emissions of a gas turbine combustion system is disclosed. The fuel supply system apparatus comprises a fuel gas supply conduit and an off-gas supply conduit in fluid communication with the fuel gas supply conduit such that the flow of an off-gas to the fuel gas supply conduit can be regulated as required by the operator to the desired fuel nozzle(s). The fuel gas supply preferably operates with natural gas and the off-gas supply preferably comprises the constituents hydrogen and methane.

Abstract: A low resistance fuse apparatus and methods of manufacture includes a first intermediate insulation layer, a second intermediate insulation layer, and a free standing fuse element layer independently formed and fabricated from each of the first and second intermediate insulation layers, The fuse element layer includes first and second contact pads and a fusible link extending therebetween. The first and second intermediate insulation layers extend on opposite sides of the free standing fuse element layer and are laminated together with the fuse element layer therebetween.

Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.

Abstract: A scanning fluorescence lifetime microscope measures modulation and phase in fluorescence emission stimulated by spatially overlapped pump and probe beams operating at different frequencies. A pump laser modulated at a first frequency is focused onto a diffraction limited spot to excite a fluorescent sample under study. Simultaneously, a probe laser modulated at a second frequency is focused onto the same spot to induce a stimulated fluorescence emission in response to the optically combined output of the pump and probe laser light. Fluorescence emitted from the sample produces a cross-correlation signal which is dependent upon the spatial overlapping of the pump and probe beams at the focal point thereby producing a beneficial axial sectioning effect. Choosing a small differency frequency between the modulation of the first and second laser sources produces a low frequency cross correlation signal even when the modulation frequencies of the pump and probe lasers are very high.

Abstract: A process for flocculating, in a liquid other than Bayer process streams, suspended solids comprised primarily of minerals other than iron oxide and tin oxide. The solids are contacted with a hydroxamated polymer. The amount of hydroxamated polymer is sufficient to increase the settling rate of the solids and to decrease the turbidity of the solids.