Abstract: The pharmaceutical composition is intended in particular for the sustained and controlled release of an effective dose of a medicinal substance. It comprises, as a carrier for the medicinal substance, a biodegradable polymer or copolymer or a mixture of biodegradable polymers and/or copolymers derived from a dicarboxylic acid selected from the acids of the Krebs cycle, and from an aliphatic diol containing 4 carbon atoms or from cyclohexane-1,4-dimethanol.

Abstract: Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance.At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles.The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.

Abstract: An excipient system containing a drug for peroral administration in the form of an ultrafine aqueous, colloidal suspension of lipid nano-pellets comprised of lipids and a surfactant of which the particle diameters of the nano-pellets range from 50-1,000 nm, preferably from 80-800 nm, the ratio of lipid to surfactant in the lipid nano-pellets ranging from 1:0.1 to 1:2.2, preferably from 1:0.22 to 1:1.2, especially from 1:1 to 1:0.22, and where the lipid nano-pellets are present in the suspension in a concentration of from 1-20% by weight. The lipid nano-pellets can be provided with pharmacologically active substances, making possible improved biological availability upon peroral administration.

Abstract: The present invention concerns a pharmacological vehicle or carrier system, which makes possible administration of the active ingredient with a high absorption thereof in the blood circulation of the patient treated therewith, in particular also in the case of oral administration. The pharmacological vehicle system according to the invention comprises ultrafine particles of a reaction product of a reactive derivative of an at least dibasic inorganic acid or an alkane-carboxylic acid having 2 or 3 carboxyl groups and optionally one or two hydroxy groups, wherein one bond of the dibasic inorganic acid or one carboxy group of the alkane-carboxylic acid is bonded to a pharmacological active ingredient containing a hydroxy group, SH group and/or a primary or secondary amino group having a ractive hydrogen atom on this group, and the other bond is bonded to the free hydroxy group of a glycerolipid having at least one free hydroxy group on the glycerol.

Abstract: Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term "alkyl" means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance. Also provided are processes for making pharmaceutical compositions containing the biodegradable particles and using the particles in pharmaceutical and diagnostic applications.

Abstract: Biodegradable particles, with a diameter smaller than 500 nanometers, formed by the micellar polymerization of an alkyl-cyano-acrylate where the term "alkyl" means a lower alkyl radical having 1 to 4 carbon atoms and containing a biologically active substance.

Abstract: Particles in the size range from about 10 to about 1000 nm, preferably less than about 500 nm, which comprise a crosslinked matrix of macromolecules of natural origin.A biologically or pharmacodynamically active material may be supported on or incorporated into the matrix.

Abstract: The present invention is concerned with novel synthetic capsules which are colloid soluble in water or suspendible or colloid soluble in hydrophobic media and consist of compatible polymeric material, more especially of acrylamide and N,N'-methylene-bis-acrylamide gel or of acrylic acid and acrylic acid methyl ester gel, which are submicroscopic and mainly micellar in size, and which contain biologically or pharmacodynamically active material, more especially proteins, antigens, pharmacologically or therapeutically active substances or pesticides, fertilizers, dyes, color forming agents, adhesives and catalysts or other technically active substances in an incorporated and/or adsorbed form, together with the method for their production and their application.

Abstract: A novel delayed release pharmaceutical preparation which is free of added enzymes and thus is stable on storage is provided. The preparation comprises particles of the therapeutically effective agent, a water-soluble calcium salt, and, if desired, a filler material, stabilizer, and other additives uniformly embedded in a triglyceride of fatty acids with 12 to 18 carbon atoms, thereby forming a granular preparation of a grain size between about 0.1 mm. and about 1.0 mm. A process of producing such a preparation is also disclosed.