Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The systems and methods include applying an electrical impulse transcutaneously through the outer skin surface of the patient to a cervical branch of the vagus nerve of the patient. The electrical impulse is sufficient to reduce a number of antibodies associated with blood clotting to reduce a level of blood clotting in the patient. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Systems, devices and methods are provided for stimulating one or more cranial nerve(s) of a user. The systems and methods combine an electrical stimulation signal with an audio signal, such as music, white noise, ambient sound, filtered music, and the like. The combination of the nerve stimulation and the audio signal may be specifically designed to treat various diseases or disorders and/or for non-medical purposes, such as improving the general well-being of the user, reducing stress and the like. In certain embodiments, the electrical impulses comprise a burst stimulation and a tonic stimulation. The burst stimulation may comprise a burst of pulses. The bursts and/or the pulses may have frequencies that vary throughout the duration of the treatment.

Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: A method for controlling a medical device. The method includes providing a conduit coupled to a pump, the pump configured to selectively provide a pressure in the conduit, a motor configured to selectively drive the pump at an operating frequency to provide the pressure in the conduit, and a controller configured to selectively drive the motor and monitor the medical device. The method includes selectively driving the motor at an indicating frequency that is different from the operating frequency when the controller identifies a value outside of a threshold for the medical device. The indicating frequency produces an indicating audible or haptic feedback that is greater than an operating audible or haptic feedback provided at the operating frequency.

Abstract: Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises stimulator having an electrode configured for contacting the outer skin surface at a target location and an energy source coupled to the stimulator, The energy source is configured to generate at least one electrical impulse and to transmit the electrical impulse transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user. In certain aspects, the systems and methods are particularly useful for non-medical purposes, such as reducing stress and anxiety, enhancing relaxation, improving sleep, energy, concentration and mood, increasing mental or physical performance, promoting mental health, recovery and wellness, generally improving the health and wellbeing of a user and/or for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Devices, systems and methods are provided for symptoms in patients, such as postoperative symptoms following major surgery and/or for treating patients in critical or intensive care. A device includes a patch having an adhesive surface for adhering to an outer skin surface of the patient and comprising one or more electrodes. An energy source is wirelessly coupled to the electrodes and configured to generate at least one electrical impulse and to wirelessly transmit the at least one electrical impulse transcutaneously from the electrodes through the outer skin surface of the patient to a selected nerve in the patient according to a stimulation protocol. The stimulation protocol includes administering at least one dose of about sixty seconds to about 5 minutes each day for a plurality of days. The doses may be administered before and after the patient’s surgery, or while the patient is being treating in intensive care.

Abstract: Devices, systems and methods are provided for treating post-operative symptoms following major surgery and/or for treating patients in critical or intensive care. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 60 seconds to about 5 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms are reduced. A stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. The doses may be administered before and after the patient's surgery, or while the patient is being treating in intensive care.

Abstract: Systems and methods are provided for treating blood clots associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Systems, devices and methods are provided for delivering electrical impulses to the vagus nerve to inhibit the reduction of telomere lengths in cellular DNA, thereby potentially increasing an individual's longevity and/or healthspan. A method comprises positioning a contact surface of a device in contact with an outer skin surface of a patient. An electrical impulse is applied transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient according to a stimulation protocol. The stimulation protocol includes at least two doses administered each day for a plurality of day. The doses each have a duration of about 60 seconds to about 5 minutes, preferably about 90 seconds to 3 minutes. The electrical impulse and the stimulation protocol are sufficient to modulate the vagus nerve such that such that the rate of telomere shortening in the patient's cellular DNA is reduced.

Abstract: Devices, systems and methods are provided for treating post-operative symptoms following major surgery and/or for treating patients in critical or intensive care. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 60 seconds to about 5 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms are reduced. A stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms. The doses may be administered before and after the patient's surgery, or while the patient is being treating in intensive care.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.

Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient. The systems and methods of the present invention reduce the expression of inflammatory mediators that are elevated in ARDS and other inflammatory or allergic disorders, thereby ameliorating the overactivity of the immune reaction in patient's suffering from certain disorders, such as the coronavirus. This therapy may include a feedback mechanism to provide potent anti-inflammatory benefits without the negative side effects of conventional immune suppression techniques and drugs, such as steroids and other nebulized drugs.

Abstract: In one aspect, the present disclosure relates to a method for configuring one or more imaging sensors of an imaging device to capture digital images for digital pulse recognition demodulation. In some embodiments, the method includes initializing one or more imaging sensors of the imaging device, determining a subset of the one or more imaging sensors to configure, setting a configuration for each of the one or more imaging sensors of the subset by defining a region of interest as a metering area for each of the one or more imaging sensors of the subset and automatically adjusting a setting for each of the one or more imaging sensors of the subset, and adjusting input parameters of a demodulation function based on a device profile of the imaging device. In some embodiments, the adjusted setting is locked to prevent further adjustment of the adjusted setting.

Abstract: In one aspect, the present disclosure relates to a method for removing noise from a digital video sequence containing a modulated light signal emitted from a beacon light source. In some embodiments, the method includes electronically receiving, by an image sensor of a device, a digital video sequence of a scene, calculating noise from the digital video sequence, wherein the noise comprises information within the digital video sequence corresponding to the un-modulated illumination of the scene, reducing the noise from the digital video sequence to obtain an isolated digital video sequence of the modulated illumination of the scene, and demodulating the emitted light signal from the isolated digital video sequence.

Abstract: In one aspect, the present disclosure relates to a method for configuring one or more imaging sensors of an imaging device to capture digital images for digital pulse recognition demodulation. In some embodiments, the method includes initializing one or more imaging sensors of the imaging device, determining a subset of the one or more imaging sensors to configure, setting a configuration for each of the one or more imaging sensors of the subset by defining a region of interest as a metering area for each of the one or more imaging sensors of the subset and automatically adjusting a setting for each of the one or more imaging sensors of the subset, and adjusting input parameters of a demodulation function based on a device profile of the imaging device. In some embodiments, the adjusted setting is locked to prevent further adjustment of the adjusted setting.

Abstract: In one aspect, the present disclosure relates to a method for configuring one or more imaging sensors of an imaging device to capture digital images for digital pulse recognition demodulation. In some embodiments, the method includes initializing one or more imaging sensors of the imaging device, determining a subset of the one or more imaging sensors to configure, setting a configuration for each of the one or more imaging sensors of the subset by defining a region of interest as a metering area for each of the one or more imaging sensors of the subset and automatically adjusting a setting for each of the one or more imaging sensors of the subset, and adjusting input parameters of a demodulation function based on a device profile of the imaging device. In some embodiments, the adjusted setting is locked to prevent further adjustment of the adjusted setting.

Abstract: In one aspect, the present disclosure relates to a method for configuring one or more imaging sensors of an imaging device to capture digital images for digital pulse recognition demodulation. In some embodiments, the method includes initializing one or more imaging sensors of the imaging device, determining a subset of the one or more imaging sensors to configure, setting a configuration for each of the one or more imaging sensors of the subset by defining a region of interest as a metering area for each of the one or more imaging sensors of the subset and automatically adjusting a setting for each of the one or more imaging sensors of the subset, and adjusting input parameters of a demodulation function based on a device profile of the imaging device. In some embodiments, the adjusted setting is locked to prevent further adjustment of the adjusted setting.

Abstract: Some injectors of the invention may include a fluid drive responsive to pressure of a working fluid (e.g., liquid, pneumatic, or both) to impart a sequence of forces to drive a delivery device (e.g., a syringe) to deliver a medical fluid (e.g., a contrast agent, a radiopharmaceutical, a drug, or a combination thereof). Some injectors may include a multimedia tube configured to pass a working fluid (e.g., air) and a light signal (e.g., infrared). Some injectors may include a peristaltic drive responsive to pressure of a working fluid.