Abstract: The present invention relates to an improved method for determining efficacies of one or more drugs for a plurality of indications, based on data obtained from a plurality of patients using standardized and integrated testing systems, as well as respective systems for performing the method, and the analysis and storage of the data as generated.

Abstract: An electromechanical assembly tool (10) including a housing (12), a torque motor (16), a planetary roller screw (18) and a linearly movable pincer head wedge (30), wherein the torque motor (16) includes a stator (38) and a rotor (40), wherein the stator (38) is mounted in the housing (12) and the rotor (40) is clamped and fixed on the rotatable but axially fixed spindle (32) of the planetary roller screw (18). The planetary roller screw (18) includes a spindle (32), a nut (34) and plural planetary rollers (36), wherein the nut (34) held in the housing (12) in an axially moveable but non-rotatable manner and axially connected to the pincer head wedge (30) such that the rotary movement of the motor rotor (40) is converted into a linear movement of the nut (34) and of the pincer head wedge (30). The rotor (40) of the torque motor (16) is directly mounted on the rotatable spindle (32) of the planetary roller screw (18).

Abstract: The invention relates to a pneumatic tool with a handle (26), valve (22), a safety switch lever (18) arranged on the handle (26) for actuating the valve (22) and a pressure medium connection (16), wherein the valve (22) comprises a valve body (28) movable between a home position and at least one further position, wherein a connection between the pressure medium connection (16) and a pressure cylinder (12) of the tool is interrupted in the home position and the connection between the pressure medium connection (16) and the pressure cylinder (12) of the tool is established in the further position. It is proposed that the pressure cylinder (12) is vented with the displacement of the valve body (28) to the home position and a pressure applied to the pressure medium connection (16) displaces the valve body (28) toward the home position when the safety switch lever (18) is released.

Abstract: A pincer tool (10) for tightening a band clamp. The pincer tool (10) includes a pincer head (12) including a base element (14), two jaw elements (16a, 16b) pivotably attached to the base element (14), wherein the jaw elements (16a, 16b) each include a jaw end (20a, 20b) and a rear end (22a, 22b) on opposite sides of the pivot point, and a wedge element (26) mounted on the base element (14) to be movable in a longitudinal direction (D) by pressure of a pressurizing agent, wherein the wedge element (26) is configured to separate the rear ends (22a, 22b) of the jaw elements (16a, 16b) when being pressed in the longitudinal direction (D) so as to move each of the jaw ends (20a, 20b) by a stroke.

Abstract: The present invention relates to improved methods and systems to analyze physiological effects as a response of cells as obtained to the exposure of a drug compound or combinations thereof. The methods of the present invention offer the particular advantage of providing more relevant results with respect to the in vivo situation, are time-and cost effective, and suitable for automatization.

Abstract: The invention relates to a pneumatic tool with a handle (26), valve (22), a safety switch lever (18) arranged on the handle (26) for actuating the valve (22) and a pressure medium connection (16), wherein the valve (22) comprises a valve body (28) movable between a home position and at least one further position, wherein a connection between the pressure medium connection (16) and a pressure cylinder (12) of the tool is interrupted in the home position and the connection between the pressure medium connection (16) and the pressure cylinder (12) of the tool is established in the further position. It is proposed that the pressure cylinder (12) is vented with the displacement of the valve body (28) to the home position and a pressure applied to the pressure medium connection (16) displaces the valve body (28) toward the home position when the safety switch lever (18) is released.

Abstract: The present invention relates to methods, and devices to analyze the phenotype and/or genotype of cells obtained from tissue samples. In particular, the present invention relates to the analysis of the response of the cells as obtained to the exposure of a drug compound or combinations thereof. The methods of the present invention offer the particular advantage of being time-effective, and suitable for automatization.

Abstract: The present invention relates to a method of characterizing a composition comprising two or more active drug compounds, the method comprising the steps of: a) a composition selection screen (CSS), in which screen a candidate composition comprising two or more active drug compounds is tested against a 3D microtissue derived from one or more cell line, and b) a composition validation screen (CVS), in which screen the candidate composition of step b) is tested against a 3D microtissue derived from a primary patient sample.

Abstract: A tension clamp (19) includes a band (20) surrounding an object to be fastened and a buckle (21) arranged on the inner band end portion (22) and surrounding the band (20), with the outer band end portion (23) extending through the buckle (21). A tool for mounting the tension clamp includes a holding device for holding the buckle (21) along with the band (20) surrounding the object to be fastened, a tensioning device for tensioning the band (20) round the object to be fastened by applying tension to the outer band end portion (23), a locking device (50) for locking the buckle (21) on the band (20), and a severing device for cutting off excessive band length. The locking device (50) has plier jaws (54) adapted to be inserted into lateral windows (25) of the buckle (21) for deforming side edge portions (24) of the other band end portion (23).

Abstract: A tool for fixing a tension clamp including a pair of levers pivotable about parallel axes and carrying at their ends plier jaws that can be moved toward each other and act on the clamp. To monitor the forces occurring during the locking of a buckle and a clamping band of the tension clamp, use is made of a device that has a housing fixed with respect to the tool and power transmission arms. Each power transmission arm is at one end elastically articulated to the housing, has at the other end a contact surface for a force sensor (18) attached to the housing and has, between its ends, a bore, in which the axis of the relevant tool lever is supported. A force/time or force/path curve obtained from the sensor signals is used as a measure of the quality of the locking between the buckle and the clamping band.

Abstract: A tool for fixing a tension clamp including a pair of levers pivotable about parallel axes and carrying at their ends plier jaws that can be moved toward each other and act on the clamp. To monitor the forces occurring during the locking of a buckle and a clamping band of the tension clamp, use is made of a device that has a housing fixed with respect to the tool and power transmission arms. Each power transmission arm is at one end elastically articulated to the housing, has at the other end a contact surface for a force sensor (18) attached to the housing and has, between its ends, a bore, in which the axis of the relevant tool lever is supported. A force/time or force/path curve obtained from the sensor signals is used as a measure of the quality of the locking between the buckle and the clamping band.

Abstract: A pyrotechnic safety element is particularly suited for use in motor vehicles. The safety element includes a conductor, a pyrotechnic unit with a pyrotechnic propellant charge, a severing member for severing the conductor, and a housing. The conductor is composed of two separate conductor parts which are joined at a joining point and are severed by the severing member when the device is triggered.

Abstract: A pyrotechnic circuit breaker, comprising a body, an igniter, a bus bar, and a piston which comprises a cutting edge and is movable along a normal direction to cut a portion of the bus bar, thereby separating the bus bar to break a circuit, wherein the cutting edge of the piston is stepped so that the portion of the bus bar is cut sequentially, in at least two successive cutting operations, characterized in that the bus bar comprises a breakable portion configured to be cut by the cutting edge of the piston, wherein said breakable portion comprises slots in order to divide the breakable portion into multiple sub-portions that are adapted to be cut sequentially by the stepped cutting edge of the piston.

Abstract: The invention relates to a thermal power station and a method for storing heat by means of a steam generator a water-steam cycle which is connected to the steam generator and to a thermal store. Said thermal store comprises a first container for a heat store medium when it is cold, a second container for the heat store medium when it is hot, and a heat exchanger which is connected to the two containers and which is connected to the heat-steam cycle via a water-steam feed line and a water-steam discharge line. The thermal store has an additional heat exchanger which is connected to the two containers, an air feed line and an air discharge line being provided, the air discharge line being connected to the combustion air feed line leading to the combustion chamber.

Abstract: A cable duct has a cable floor with side walls that are attached to the cable floor. The cable floor has a three-dimensional laying structure, running inside a base plane and also in a z-direction, and it is divided into several floor segments. The segments form a combined injection-molded component and are joined together by hinges, so that at least a major portion of all floor segments is located in the base plane. In addition, cover segments preferably form part of the combined injection-molded component, such that, by way of just one injection molding tool, the entire three-dimensional cable duct can be produced as a two-dimensional injection-molded component, from which the three-dimensional structure of the cable duct is produced.

Abstract: A tension clamp (19) includes a band (20) surrounding an object to be fastened and a buckle (21) arranged on the inner band end portion (22) and surrounding the band (20), with the outer band end portion (23) extending through the buckle (21). A tool for mounting the tension clamp includes a holding device for holding the buckle (21) along with the band (20) surrounding the object to be fastened, a tensioning device for tensioning the band (20) round the object to be fastened by applying tension to the outer band end portion (23), a locking device (50) for locking the buckle (21) on dem band (20), and a severing device for cutting off excessive band length. The locking device (50) has plier jaws (54) adapted to be inserted into lateral windows (25) of the buckle (21) for deforming side edge portions (24) of the other band end portion (23).

Abstract: A pyrotechnic safety element is particularly suited for use in motor vehicles. The safety element includes a conductor, a pyrotechnic unit with a pyrotechnic propellant charge, a severing member for severing the conductor, and a housing. The conductor is composed of two separate conductor parts which are joined at a joining point and are severed by the severing member when the device is triggered.

Abstract: A pyrotechnic circuit breaker (1), comprising a body (2), an igniter (4), a piston (5) and a bus bar (6), wherein the igniter (4), the piston (5) and the bus bar (6) are adapted to be accommodated within the body (2), and wherein the piston (5) comprises a cutting edge (51) and is adapted move along a normal direction (Z-Z) to cut a portion (61) of the bus bar (6), thereby separating the bus bar (6) into a proximal portion and a distal portion in order to break a circuit, wherein the cutting edge (51) of the piston (5) is stepped so that the portion of the bus bar (6) is cut sequentially, in at least two successive cutting operations along the movement of the piston (5) from a raised position to a lowered position, characterized in that the bus blade (6) comprises a breakable portion (61) configured to be cut by the cutting edge (51) of the piston (5), wherein said breakable portion (61) comprises slots (62) in order to divide the breakable portion (61) into multiple sub-portions (61a, 61b, 61c) that are adap

Abstract: A cable duct has a cable floor with side walls that are attached to the cable floor. The cable floor has a three-dimensional laying structure, running inside a base plane and also in a z-direction, and it is divided into several floor segments. The segments form a combined injection-molded component and are joined together by hinges, so that at least a major portion of all floor segments is located in the base plane. In addition, cover segments preferably form part of the combined injection-molded component, such that, by way of just one injection molding tool, the entire three-dimensional cable duct can be produced as a two-dimensional injection-molded component, from which the three-dimensional structure of the cable duct is produced.